A kind of preparation method of magnesium L-ascorbic acid-2-monophosphate

Abstract

The invention is a preparation method of magnesium L-ascorbic acid-2-monophosphate. The method does not need to use an organic solvent in the preparation process, the post-treatment is simple, no environmental pollution problem is caused, and the prepared L-ascorbic acid-2-monophosphate magnesium has high purity. It is characterized in that: add water, L-ascorbic acid and calcium chloride into a reaction kettle at -5°C to 10°C, stir, then slowly add 20%-60% sodium hydroxide or calcium hydroxide aqueous solution, and adjust the pH value from 6 to 10°C. 9.5, then add 0.8-1.5 times the amount of VC sodium trimetaphosphate, keep the temperature at 15 degrees Celsius to 35 degrees Celsius; wash the above reaction product with water, then use hydrochloric acid, sulfuric acid or oxalic acid to adjust the pH value to 0.5-3.0, and then filter , the filtrate was passed through a weakly basic anion exchange resin, and eluted with 0.02M hydrochloric acid and 0.2M ~ 0.8M hydrochloric acid in turn; the pH value of the eluted part was adjusted with magnesium oxide, filtered to remove the precipitate, and the filtrate was concentrated under reduced pressure at 40°C to the original volume. 1 / 5, add 95% ethanol whose volume is 2-4 times of the concentrated filtrate, then crystallize, collect by centrifugation, wash, crush and dry.

Description

(1) Technical field [0001] The invention relates to a preparation method of L-ascorbic acid derivatives, in particular to a preparation method of L-ascorbic acid-2-monophosphate magnesium. (2) Background technology [0002] The chemical structural formula of L-ascorbic acid (ascorbic acid) (vitamin C, hereinafter referred to as VC) is, This is an acidic enol-structured lactone, which naturally exists in fresh vegetables and fruits and is an essential vitamin for the human body. VC has been widely used in medicine, food, cosmetics and animal breeding and other fields. But VC its C 2 、C 3 The hydrogen of the enolate hydroxyl group is easy to dissociate, and it is easily oxidized into dehydrovitamin C by air and other oxidants, and will soon undergo an irreversible decomposition reaction and lose the VC reducing ability. It is found that the activity of VC is mainly derived from the two hydroxyl groups on its enol structure. If any of the hydroxyl groups is esterified with...

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Problems solved by technology

[0004] In view of the above problems, the present invention provides a preparation method of L-ascorbic acid-2-magnesium monophosphate, which does not need to use organic solvents in the preparation process, the post-treatment is simple, and will not cause environmental pollution problems, and the prepared Magnesium L-Ascorbyl-2-monophosphate is of high purity

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