Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Biological activity glass mesoporous microsphere and preparation method thereof

A bioactive glass and mesoporous technology, applied in the field of biomedical microsphere materials, can solve the problems of difficult control of degradation rate, acidity of degradation products, sudden drug release, etc., achieving small particle size, good dispersibility, and uniform particle size. Effect

Inactive Publication Date: 2008-12-03
SOUTH CHINA UNIV OF TECH
View PDF3 Cites 34 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the microspheres used for drug carriers are organic polymer materials, such as polylactic acid microspheres, polycaprolactone microspheres, chitosan microspheres, albumin microspheres, etc. These materials have the following properties: Defects: The degradation products of polylactic acid and the like are acidic, which is easy to cause cytotoxicity; the degradation rate is not easy to control, and it is easy to cause sudden release of drugs

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Biological activity glass mesoporous microsphere and preparation method thereof
  • Biological activity glass mesoporous microsphere and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Add 2N hydrochloric acid into deionized water, stir and mix evenly, adjust the pH value to 1, add ethyl orthosilicate (TEOS), triethyl phosphate (TEP) and calcium nitrate tetrahydrate in sequence for hydrolysis reaction, and finally add organic template Polyethylene glycol was added, and a transparent, uniform and stable sol was obtained after fully stirring. Among them, the molar ratio of ethyl orthosilicate, triethyl phosphate, and calcium nitrate tetrahydrate is 60:4:36, the molar ratio of deionized water to ethyl orthosilicate is 10:1, polyethylene glycol and orthosilicate The molar ratio of ethyl silicate is 0.002;

[0024] (2) Static aging of the sol obtained in step (1) for 4 days to form a wet gel;

[0025] (3) Soak and wash the gel with absolute ethanol 6 times for 10 minutes, and the volume ratio of absolute ethanol to wet gel is 10:1;

[0026] (4) Drying the wet gel obtained in step (3) in an oven at 60°C for 3 days, and then drying in an oven at 120°C for ...

Embodiment 2

[0030] Add 2N nitric acid into deionized water, stir and mix evenly, adjust the pH value to 3, add ethyl orthosilicate (TEOS), triethyl phosphate (TEP) and calcium nitrate tetrahydrate in sequence for hydrolysis reaction, and finally add organic template Polyethylene glycol was added, and a transparent, uniform and stable sol was obtained after fully stirring. Among them, the molar ratio of ethyl orthosilicate, triethyl phosphate, and calcium nitrate tetrahydrate is 80:4:16, the molar ratio of deionized water to ethyl orthosilicate is 8:1, polyethylene glycol and orthosilicate The molar ratio of ethyl silicate is 0.004;

[0031] (2) Static aging of the sol obtained in step (1) for 4 days to form a wet gel;

[0032] (3) Soak and wash the gel with absolute ethanol 6 times for 10 minutes, and the volume ratio of absolute ethanol to wet gel is 10:1;

[0033] (4) Drying the wet gel obtained in step (3) in an oven at 60°C for 3 days, and then drying in an oven at 120°C for 3 days ...

Embodiment 3

[0037] Add 10% ammonia water into deionized water, stir and mix evenly, adjust the pH value to 13, add ethyl orthosilicate (TEOS), triethyl phosphate (TEP) and calcium nitrate tetrahydrate in sequence for hydrolysis reaction, and finally add organic The template agent is polyethylene glycol, and a transparent, uniform and stable sol can be obtained after fully stirring. Among them, the molar ratio of ethyl orthosilicate, triethyl phosphate, and calcium nitrate tetrahydrate is 60:4:36, the molar ratio of deionized water to ethyl orthosilicate is 12:1, polyethylene glycol and orthosilicate The molar ratio of ethyl silicate is 0.007;

[0038] (2) aging the sol obtained in step (1) statically for 6 days to form a wet gel;

[0039] (3) Soak and wash the gel with absolute ethanol 6 times for 20 minutes, and the volume ratio of absolute ethanol to wet gel is 8:1;

[0040] (4) drying the wet gel obtained in step (3) in an oven at 80°C for 3 days, and then drying in an oven at 100°C ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
The average particle sizeaaaaaaaaaa
Specific surface areaaaaaaaaaaa
Mesopore diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a biological activity glass meso-porous microsphere and a preparation method thereof. The biological activity glass meso-porous microsphere comprises the following chemical compositions in percentage by weight: 16 to 36 percent of CaO, 4 percent of P2O5 and 60 to 80 percent of SiO; the average grain diameter is between 2 and 5 mu m; the grains are sphere -shaped; the specific surface area of the grains is between 30.6m<2> / g and 89.7m<2> / g; and the meso-porous diameter is between 1.9 and 4.1nm. The method adopts the organic template method, comprising the following the steps that: a catalysts is added in deionized water, the mixed solution is added with tetraethoxysilane, triethyl phosphate and calcium nitrate tetrahydrate for hydrolysis reaction, the mixed solution is added with organic template polyethylene glycol and fully stirred to obtain sol, the sols is subject to aging to form wet gel, the wet gel is immersed in and washed by absolute ethyl alcohol and dried to obtain dry gel, and the dry gel is put in a crucible for heat treatment to obtain the finished products. The biological activity glass meso-porous microsphere has the advantages of higher biological activity and degradation property and good biological compatibility.

Description

technical field [0001] The invention relates to a biomedical microsphere material, in particular to a bioactive glass mesoporous microsphere and a preparation method thereof. Background technique [0002] Drug carrier is a kind of biomaterial product that gradually rises with the development of biomaterial science, clinical medicine and pharmacology. The drug enters the human body through the carrier, and the adsorption, encapsulation and bonding of the drug by the carrier makes the release site, speed and mode of the drug more selective and controllable, realizing the slow release and targeted delivery of the drug, so as to better play the role of drug therapy Effect. At present, most of the microspheres used for drug carriers are organic polymer materials, such as polylactic acid microspheres, polycaprolactone microspheres, chitosan microspheres, albumin microspheres, etc. These materials have the following properties: Defects: The degradation products of polylactic acid...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K47/24A61K47/02A61K47/04
Inventor 赵娜如陈晓峰王迎军郭常亮孟永春
Owner SOUTH CHINA UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com