Poly-lactide, poly-glycolide and preparation for copolymer of the same

A technology of polyglycolide and polylactide, which is applied in the field of preparation of polylactide, polyglycolide and polylactide and polyglycolide copolymer, can solve the problem of large equipment investment, difficult heat dissipation of materials, and time-consuming dissolution and other problems, to achieve the effect of large equipment investment, high molecular weight and simple equipment

Inactive Publication Date: 2011-05-04
胡权
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Compared with the existing bulk polymerization technology, the preparation method of the present invention solves the problem of difficult heat dissipation of materials in the preparation process, time-consuming dissolution in the post-treatment process, high cost and large equipment investment caused by melting granulation or crushing granulation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Add a stirrer, 50 grams of DL lactide (monomer), and 100 milliliters of nonane into a three-necked flask with a volume of 250 milliliters, heat the three-necked flask in an oil bath, first raise the temperature to 130 ° C, and pass through while heating. Nitrogen, remove the system air, when the lactide in the system melts completely, add the silicone oil of catalyst stannous octoate and 0.5 milliliter (acting as stabilizer), the molar ratio of catalyst and lactide is 6 / 10,000, heat up to 145 Between ℃ and 150℃, adjust the rotation speed to 500rpm, react for 6 hours, stop heating, continue to stir until it cools to room temperature (it can prevent particles from sticking at high temperature), filter the liquid, and obtain a particle size of 2 mm to Colorless, transparent polylactide (polylactic acid) particles between 0.2 milligrams. After drying, use chloroform as solvent, measure the molecular weight at 25°C, according to the formula:

[0010] [η]=2.21×10 -4 m V 0...

Embodiment 2

[0014] [η]=5.45×10 -4 m V 0.73

[0015] The calculated viscosity-average molecular weight is about 60,000.

[0016] Example 3:

Embodiment 3

[0018] Example 4:

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PUM

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Abstract

The invention discloses a preparation method for poly-lactide acid, polyglycolide and copolymer of the poly-lactide acid and the polyglycolide, which adopts the steps that arbitrary one of lactide or glycolide or the mixture thereof is considered as a monomer, suspending agent and catalyzer are added into the monomer, then the agitation is performed, and the granular product is polymerized. The suspending agent is alkane with the boiling point of higher than 90 DEG C, and the polymerizing temperature is higher than the melting point of the monomer but less than the boiling point of the suspending agent. The preparation method of the invention can be applied in the industrialized large-scale production, effectively solving the problems existing in the prior art that the heat emission of the materials is difficult during the preparation process, and the dissolution is time-consuming, the cost of melting granulating or crushing granulating is high, and the investment of the equipment is large during the late processing process. The product polymerized by utilizing the method has the advantages that the molecular weight is high, the purity is high, the product directly presents a granular shape, the re-granulation operation is not required, the process is simple, and both the equipment investment and the labor cost are very low.

Description

technical field [0001] The invention relates to a preparation method of polylactide, polyglycolide and polylactide-polyglycolide copolymer. Background technique [0002] Polylactic acid, polyglycolic acid and their copolymers are currently the most widely used degradable medical materials in the market. Their production method is mainly bulk polymerization. Theoretically, bulk polymerization will make the product pure and high in molecular weight, but it is difficult for bulk polymerization to dissipate heat, and it is easy to cause the product in the middle of the reactor to become darker in color and lower in molecular weight. Melting temperature, so it is very difficult to post-process. Generally, in small-scale preparations, after the polymerization is completed, first dissolve it with a solvent (such as chloroform, acetone, etc.), and then add a precipitant (such as ethanol, water, etc.) ) for precipitation. The process is very time-consuming and the solvent consumpt...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G63/78C08G63/08
Inventor 胡权
Owner 胡权
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