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Method for refining cholesterin by activated carbon fixed bed adsorption process

A fixed bed adsorption and activated carbon technology, applied in the field of adsorption and separation, can solve the problems of low content, environmental pollution and high cost, and achieve the effects of high yield and content, good decolorization effect and low production cost

Inactive Publication Date: 2009-03-18
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the defect of this method is that the amount of metal chloride is relatively large, and the yield is not high.
In addition, if zinc chloride is used, it will also produce heavy metal wastewater that is difficult to treat due to the introduction of heavy metal ions, causing environmental pollution
[0009] Japanese patent JP07278181 (1995) adopts the cavity of cyclodextrin to separate the sterols in lanolin by the special complexing ability of sterols, but because the price of cyclodextrin itself is higher, and the loss of cyclodextrin in the decomplexation process is relatively serious, Therefore this method is not suitable for the industrialized production of sterols in lanolin
[0010] Generally speaking, in the prior art, the methods for further purifying and refining the crude cholesterol prepared from lanolin all have one or more problems of low yield, low content, and high cost, and are not suitable for industrialization. Production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Weigh 100.0 g of a crude product with a cholesterol content of 23.8%, and dissolve it in 1000 ml of methanol at room temperature to prepare a raw material solution. The size of the fixed bed is φ5cm×25cm, and 113g of coarse-pore granular activated carbon is filled inside, and the bed volume (BV) is 490mL. The volume of the raw material liquid prepared above is roughly equivalent to 2BV. The raw material liquid passes through the fixed bed at a flow rate of 0.2BV / h at 40°C, and the cholesterol in the raw material liquid is adsorbed on the activated carbon of the fixed bed.

[0041] Continue to flush the fixed bed with 1.0BV of methanol at a flow rate of 1.0BV / h to recover a small amount of raw material liquid remaining in the gap of the fixed bed, collect the liquid obtained by washing and put it into the raw material liquid for mechanical use.

[0042] At 40°C, use 3.0 BV of acetone to flow through the fixed bed washed with methanol at a flow rate of 1.5 BV / h to elute ...

Embodiment 2

[0045] Weigh 100.0 g of a crude product with a cholesterol content of 23.8%, and dissolve it in 1000 ml of methanol at room temperature to prepare a raw material solution. The size of the fixed bed is φ5cm×25cm, and it is filled with 113g of coarse-pore granular activated carbon that has been used once and regenerated with n-hexane and balanced with methanol. The bed volume (BV) is 490mL. The volume of the raw material liquid prepared above is roughly equivalent to 2BV. The raw material liquid passes through the fixed bed at a flow rate of 0.2BV / h at 40°C, and the cholesterol in the raw material liquid is adsorbed on the activated carbon of the fixed bed.

[0046] Continue to flush the fixed bed with 1.0BV of methanol at a flow rate of 1.0BV / h to recover a small amount of raw material liquid remaining in the gap of the fixed bed, collect the liquid obtained by washing and put it into the raw material liquid for mechanical use.

[0047] At 40°C, use 3.0 BV of acetone to flow t...

Embodiment 3

[0050] Weigh 100.0 g of a crude product with a cholesterol content of 23.8%, and dissolve it in 1000 ml of methanol at room temperature to prepare a raw material solution. The size of the fixed bed is φ5cm×25cm, filled with 113g of granular activated carbon that has been used 10 times and regenerated with n-hexane and balanced with methanol. The bed volume (BV) is 490mL. The volume of the raw material liquid prepared above is roughly equivalent to 2BV. The raw material liquid passes through the fixed bed at a flow rate of 0.2BV / h at 40°C, and the cholesterol in the raw material liquid is adsorbed on the activated carbon of the fixed bed.

[0051] Continue to flush the fixed bed with 1.0BV of methanol at a flow rate of 1.0BV / h to recover a small amount of raw material liquid remaining in the gap of the fixed bed, collect the liquid obtained by washing and put it into the raw material liquid for mechanical use.

[0052] At 40°C, use 3.0 BV of acetone to flow through the fixed b...

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Abstract

The invention discloses a method for refining cholesterol through an active carbon fixed bed adsorption method. According to the method, lanolin is used as raw materials for preparing a crude cholesterol product which is adsorbed and separated by the active carbon fixed bed so as to obtain a refined cholesterol product. The mass percentage of cholesterol in the refined cholesterol product is more than 90 percent, and the cholesterol yield is higher than 80 percent. The method is characterized by wide raw material adaptability, high product quality, low manufacturing cost, less pollution, and the like. In addition, the method is suitable for industrialized production because of simple process and convenient operation.

Description

technical field [0001] The invention relates to the technical field of adsorption and separation, in particular to a method for refining cholesterol by using activated carbon as an adsorbent and adopting a fixed-bed process. Background technique [0002] Cholesterol is an important pharmaceutical intermediate, through which vitamin D3 and a series of steroidal anti-inflammatory drugs can be synthesized; in addition, cholesterol has become an indispensable additive in high-end cosmetics due to its excellent lubricating properties on the skin. At present, there are roughly two ways to prepare cholesterol: one is to extract it from the brainstem and viscera of animals; the other is to extract it from lanolin. Due to doubts about the potential harm of disease-causing genes in animal organs to humans, the former approach is increasingly restricted by the international market and gradually replaced by the latter. [0003] Lanolin is an ester substance secreted by sheep's sebaceou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J9/00C07J75/00B01D15/08
Inventor 苏宝根邢华斌魏作君杨亦文苏云任其龙
Owner ZHEJIANG UNIV