Water-soluble fullerenes derivates, composition and application thereof in preparation of medicament for inhibiting tumor growth and metastasis

Abstract

The invention provides a water-soluble fullerene derivative, composite and the applications in the preparation process of medicament used for inhibiting growth and transfer of tumor; the derivative is fullerols presented by a general formula: C60OxHy; wherein, y is more than 10 and less than or equal to x; x is less than 50 and more than or equal to y; alternatively, the derivative is fullerene carboxyl derivative presented by the general formula C60(C(COOH)2)n; wherein, n is equal to 1-3; the tumor inhibiting composite comprises the grains of the water-soluble fullerene derivative and pharmaceutically acceptable carrier. The invention has the advantages that: compared with cyclophosphamide, cisplatin, paclitaxel, and the like, which are generally applied to clinic at present; the fullerols and carboxylic fullerene nano grains have small dosage, low toxicity and can inhibite the growth and transfer of the tumor.

Description

technical field [0001] The invention relates to a novel nanometer material and its application in biomedicine. Specifically, involving fullerenol particles [C 60 o x h y ] n (10<Y≤X<50, n=15-50) and fullerene carboxylic acid derivative C60(C(COOH) 2 ) n (n=an integer of 1-4) and its application in inhibiting tumor growth and metastasis. Background technique [0002] Malignant tumor is an important disease that threatens human health and has become the main cause of human death. In China, lung cancer, gastric cancer, liver cancer and breast cancer are the tumors with the highest incidence rates. Statistics show that in China, the incidence rate of lung cancer is about 27 / 10,000, the incidence rate of gastric cancer is 26.8 / 10,000, and the incidence rate of breast cancer is about 16.39 / 10,000. At present, at least 7 million people in the world die of cancer, of which about 1.3 million are in my country. Tumor is a common and frequently-occurring disease that ser...

AI Technical Summary

Problems solved by technology

At present, surgical resection, chemotherapy and radiotherapy are the main methods for treating malignant tumors, but these methods all have their insurmountable defects: surgery can only remove the tumor mass visible to the naked eye but cannot remove the residual tumor cells; chemotherapy and radiotherapy have toxic and side effects Very strong, while inhibiting tumor growth, it also damages the normal tissues and organs of the body, thereby sharply reducing the quality of life of patients; for example, cyclophosphamide, doxorubicin, cisplatin, etc., produce bone marrow suppression while playing a therapeutic role. Severe side effects such as severe reactions in the gastrointestinal tract and kidney toxicity seriously limit its clinical dosage

[0006] due to C 60 It has strong hydrophobicity and low solubility in polar solutions, so it is difficult to use directly in physiological media, which seriously affects the application of fullerenes in biomedicine, so improving C 60 The water solubility becomes the key to the research

Images