Chemical synthesis method of pyroglutamic acid alcohol and intermediates thereof

A pyroglutamic acid alcohol, chemical synthesis technology, applied in organic chemistry and other directions, can solve the problems of harsh equipment requirements, poor operating conditions, large catalyst consumption, etc., and achieves less demanding equipment requirements, easy subsequent purification, and operating conditions good effect
CN101407488AInactive Publication Date: 2009-04-15SICHUAN TONGSHENG AMINO ACID CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SICHUAN TONGSHENG AMINO ACID CO LTD
Publication Date
2009-04-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a chemosynthesis method of pyroglutamic acid alcohol and intermediates thereof, i.e., pyroglutamic acid and pyroglutamic acid ester, wherein, glutamic acid is used as raw material which is dehydrated and cyclized in a heating environment to generate pyroglutamic acid which is then reacted with absolute alcohol under the effect of catalyst to generate pyroglutamic acid ester; finally, pyroglutamic acid ester is dissolved in organic solvent to be reduced by reducing agent to generate pyroglutamic acid alcohol. The chemosynthesizing method has the advantages that the raw material is easy to get, the process route is short, catalyst and acid consumption are little, the operation environment is good, the yield coefficient is high, the cost is low, the purity is high and the method is easy for industrialization.
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Description

technical field

[0001] The invention relates to a chemical synthesis method of pyroglutamic acid alcohol and its intermediates, especially using glutamic acid as a raw material, dehydration and cyclization in a heating environment to generate pyroglutamic acid, and then pyroglutamic acid is used as a catalyst Then react with anhydrous alcohol to generate pyroglutamic acid ester, and finally dissolve pyroglutamic acid ester in an organic solvent and reduce it with a reducing agent to generate pyroglutamic acid alcohol. As a natural heat preservation agent, pyroglutamic acid is widely used in cosmetics and daily products. Its derivatives used to synthesize pyroglutamic acid are widely used in the chemical industry. The main raw material of methyl / ethyl glutamate; pyroglutamate is not only the main raw material for the synthesis of pyroglutamic acid alcohol and the intermediate of other drugs, but also the raw material for the synthesis of 2-pyrrolidone-5-carboxylic acid long-cha...

Claims

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