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Titanium or titanium alloy material with modified surface as well as preparation method and use thereof

A surface modification, titanium alloy technology, applied in medical science, coating, prosthesis, etc., to achieve good osteoblast compatibility, controllable coating thickness, and promote proliferation and differentiation

Inactive Publication Date: 2009-04-22
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, no surface-modified titanium and titanium alloy materials have been successfully applied clinically.

Method used

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  • Titanium or titanium alloy material with modified surface as well as preparation method and use thereof
  • Titanium or titanium alloy material with modified surface as well as preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] This embodiment is a surface-modified titanium film, and its preparation method comprises the following steps:

[0034] A, take by weighing chitosan 0.5g, adding concentration is 50mL of acetic acid solution of 10mL / L, magnetic stirring makes dissolving for 20 minutes, makes the chitosan solution that mass percent concentration is 1%;

[0035] b. Weigh 1.0 g of silk fibroin, add 50 mL of deionized water to dissolve it, and make a silk fibroin solution with a concentration of 2% by mass;

[0036] c. Weigh 0.025g of EDC and 0.533g of MES, add 50mL of deionized water to dissolve, and make a mixed solution containing EDC with a concentration of 0.05% by mass and MES with a concentration of 0.05mol / L;

[0037] d, the titanium film is placed in the chitosan solution prepared in step a, soaked for 10 minutes, and taken out;

[0038] e. Washing the titanium membrane processed in step d twice with deionized water, soaking for 2 minutes each time;

[0039] f. Put the titanium f...

Embodiment 2

[0044] This embodiment is a surface-modified titanium film, and its preparation method comprises the following steps:

[0045] A, take chitosan 1.0g, add concentration and be 50mL of acetic acid solution of 10mL / L, magnetic stirring makes dissolving for 20 minutes, makes the chitosan solution that mass percent concentration is 2%;

[0046] b. Weigh 2.5 g of silk fibroin, add 50 mL of deionized water to dissolve, and make a silk fibroin solution with a concentration of 5% by mass;

[0047] c. Weigh 0.050g of EDC and 1.066g of MES, add 50mL of deionized water to dissolve, and make a mixed solution containing EDC with a mass percentage concentration of 0.1% and MES with a concentration of 0.1mol / L;

[0048] d, the titanium film is placed in the chitosan solution prepared in step a, soaked for 20 minutes, and taken out;

[0049] e. Washing the titanium film treated in step d with deionized water 3 times, soaking for 1 minute each time;

[0050] f. Put the titanium film cleaned i...

Embodiment 3

[0055] Present embodiment is the Ti-6Al-4V titanium alloy of surface modification, and its preparation method comprises the following steps:

[0056] A, take chitosan 1.5g, add concentration and be 50mL of the acetic acid solution of 20mL / L, magnetic stirring makes dissolving for 20 minutes, makes the chitosan solution that mass percent concentration is 3%;

[0057] b. Weigh 4.0 g of silk fibroin, add 50 mL of deionized water to dissolve it, and make a silk fibroin solution with a concentration of 8% by mass;

[0058] c. Weigh 0.075g of EDC and 2.133g of MES, add 50mL of deionized water to dissolve, and make a mixed solution containing EDC with a concentration of 0.15% by mass and MES with a concentration of 0.2mol / L;

[0059] d, put titanium alloy in the chitosan solution that step a makes, soak for 15 minutes, take out;

[0060] e, cleaning the titanium alloy processed by step d with deionized water 3 times, soaking for 1 minute each time;

[0061] f. Put the titanium allo...

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Abstract

The invention discloses a surface modified titanium or titanium alloy material. The surface of the material is provided with at least five layers of bioactive coats consisting of double-layer chitosan-silk fibroin. The material has favorable osteoplast compatibility, can promote multiplication and division of osteoplast, shows potential for further developing a novel medical hard tissue implant material, and has favorable clinical application prospect. The surface modified titanium or titanium alloy material can be prepared by a self-assembly method layer by layer; alternate layers of polycation electrolyte chitosan and polyanion electrolyte gelatin are laminated and assembled on the surface of the titanium or titanium alloy material through electrostatic adsorption action; and the preparation method is simple, can control coating thickness, is not affected by size and shape of the material, is suitable for the materials with complex appearance, has moderate preparation conditions, needs no special equipment, and has low production cost, strong practicability, and better popularization and application values.

Description

technical field [0001] The invention relates to a metal material, in particular to a surface-modified titanium or titanium alloy material, and to a preparation method and application of the surface-modified titanium or titanium alloy material. Background technique [0002] At present, bone defects caused by trauma, fractures, osteoporosis and other diseases are common clinical problems. Every year, millions of hard tissue implants are used for bone fixation or functional tissue replacement around the world. Due to their excellent biocompatibility and comprehensive mechanical properties, titanium and titanium alloys have become the most widely used hard tissue implant materials in clinical practice, and are used to make artificial joints, internal fixation devices and bone reconstruction materials. However, titanium and titanium alloy materials themselves lack biological activity and have no ability to induce osseointegration. Implants made of them cannot form a firm and long...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/06
Inventor 蔡开勇胡燕罗忠
Owner CHONGQING UNIV
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