Titanium or titanium alloy material with modified surface as well as preparation method and use thereof

A surface modification, titanium alloy technology, applied in medical science, coating, prosthesis, etc., to achieve good osteoblast compatibility, controllable coating thickness, and promote proliferation and differentiation

Inactive Publication Date: 2009-04-22
CHONGQING UNIV
View PDF0 Cites 15 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, no surface-modified titanium and titanium allo

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Titanium or titanium alloy material with modified surface as well as preparation method and use thereof
  • Titanium or titanium alloy material with modified surface as well as preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0032] Example one

[0033] This embodiment is a surface-modified titanium film, and its preparation method includes the following steps:

[0034] a. Weigh 0.5g of chitosan, add 50mL of acetic acid solution with a concentration of 10mL / L, and magnetically stir for 20 minutes to dissolve to prepare a chitosan solution with a mass percentage of 1%;

[0035] b. Weigh 1.0 g of silk fibroin, add 50 mL of deionized water to dissolve, and prepare a silk fibroin solution with a concentration of 2% by mass;

[0036] c. Weigh 0.025g of EDC and 0.533g of MES, add 50mL of deionized water to dissolve, and prepare a mixed solution containing EDC with a concentration of 0.05% by mass and MES with a concentration of 0.05mol / L;

[0037] d. Put the titanium film in the chitosan solution prepared in step a, soak for 10 minutes, and take it out;

[0038] e. Wash the titanium membrane treated in step d with deionized water twice, soaking for 2 minutes each time;

[0039] f. Put the titanium membrane c...

Example Embodiment

[0043] Example two

[0044] This embodiment is a surface-modified titanium film, and its preparation method includes the following steps:

[0045] a. Weigh 1.0g of chitosan, add 50mL of acetic acid solution with a concentration of 10mL / L, magnetically stir for 20 minutes to dissolve, and prepare a chitosan solution with a mass percentage of 2%;

[0046] b. Weigh 2.5 g of silk fibroin, add 50 mL of deionized water to dissolve, and prepare a silk fibroin solution with a concentration of 5% by mass;

[0047] c. Weigh 0.050g of EDC and 1.066g of MES, add 50mL of deionized water to dissolve, and prepare a mixed solution containing EDC with a concentration of 0.1% by mass and MES with a concentration of 0.1mol / L;

[0048] d. Put the titanium film in the chitosan solution prepared in step a, soak for 20 minutes, and take it out;

[0049] e. Wash the titanium membrane treated in step d with deionized water 3 times, soaking for 1 minute each time;

[0050] f. Put the titanium membrane clea...

Example Embodiment

[0054] Example three

[0055] This embodiment is a surface-modified Ti-6Al-4V titanium alloy, and its preparation method includes the following steps:

[0056] a. Weigh 1.5g of chitosan, add 50mL of acetic acid solution with a concentration of 20mL / L, magnetically stir for 20 minutes to dissolve, and prepare a chitosan solution with a mass percentage of 3%;

[0057] b. Weigh 4.0 g of silk fibroin, add 50 mL of deionized water to dissolve, and prepare a silk fibroin solution with a mass percentage of 8%;

[0058] c. Weigh 0.075g of EDC and 2.133g of MES, add 50mL of deionized water to dissolve, and prepare a mixed solution containing EDC with a concentration of 0.15% by mass and MES with a concentration of 0.2mol / L;

[0059] d. Put the titanium alloy in the chitosan solution prepared in step a, soak for 15 minutes, and take it out;

[0060] e. Wash the titanium alloy treated in step d with deionized water 3 times, soaking for 1 minute each time;

[0061] f. Put the titanium alloy c...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Cell densityaaaaaaaaaa
Login to view more

Abstract

The invention discloses a surface modified titanium or titanium alloy material. The surface of the material is provided with at least five layers of bioactive coats consisting of double-layer chitosan-silk fibroin. The material has favorable osteoplast compatibility, can promote multiplication and division of osteoplast, shows potential for further developing a novel medical hard tissue implant material, and has favorable clinical application prospect. The surface modified titanium or titanium alloy material can be prepared by a self-assembly method layer by layer; alternate layers of polycation electrolyte chitosan and polyanion electrolyte gelatin are laminated and assembled on the surface of the titanium or titanium alloy material through electrostatic adsorption action; and the preparation method is simple, can control coating thickness, is not affected by size and shape of the material, is suitable for the materials with complex appearance, has moderate preparation conditions, needs no special equipment, and has low production cost, strong practicability, and better popularization and application values.

Description

technical field [0001] The invention relates to a metal material, in particular to a surface-modified titanium or titanium alloy material, and to a preparation method and application of the surface-modified titanium or titanium alloy material. Background technique [0002] At present, bone defects caused by trauma, fractures, osteoporosis and other diseases are common clinical problems. Every year, millions of hard tissue implants are used for bone fixation or functional tissue replacement around the world. Due to their excellent biocompatibility and comprehensive mechanical properties, titanium and titanium alloys have become the most widely used hard tissue implant materials in clinical practice, and are used to make artificial joints, internal fixation devices and bone reconstruction materials. However, titanium and titanium alloy materials themselves lack biological activity and have no ability to induce osseointegration. Implants made of them cannot form a firm and long...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61L27/34A61L27/06
Inventor 蔡开勇胡燕罗忠
Owner CHONGQING UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap