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Chinese medicine granule containing astragalus extract and preparation method thereof

A technology of astragalus extract and traditional Chinese medicine granules is applied in the directions of medical formulations containing active ingredients, pharmaceutical formulations, and medical formulations with non-active ingredients, etc. question

Inactive Publication Date: 2012-03-28
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Several common granule preparation processes and their existing defects: 1. Traditional granule preparation process, due to the high viscosity of traditional Chinese medicine extracts, most of the traditional granule preparation methods have low drug loading, unsightly appearance, and poor taste , easy to absorb moisture and other problems
5. In the field of preparations, there are also fluidized bed bottom spraying or side spraying techniques to manufacture western medicine pellets or spherical granules, which are mostly used in the development of sustained release preparations. Therefore, the developed products generally have slow and controlled release characteristics, and do not have immediate release characteristics.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] The preparation of active ingredient of the present invention:

[0077] Salvia miltiorrhiza extract: obtained according to the preparation method of Chinese patent application (application number 02117923.9). The specific extraction method is as follows: 5 kg of Salvia miltiorrhiza is crushed into coarse powder, then heated and extracted three times with deionized water at 100° C. in a slightly boiling state. Add 5.5 times the amount of water for the first time and heat for 1 hour; add 3 times the amount of water for the second and third times and heat for 0.5 hours respectively. After adjusting the pH value of the extract to 2 with 10% hydrochloric acid, filter it, and put the filtrate on a polyamide column (the amount of dry resin is 2 / 3 of the crude drug amount). Wash with 5 times the amount of deionized water, and continue to elute with 0.1% aqueous sodium bicarbonate solution, the amount of which is 5 times the volume of the column. Collect the eluate, adjust the...

Embodiment 2

[0084] Preparation of the active ingredient of the present invention: take 1000 g of the salvia miltiorrhiza extract of Example 1, 2000 g of the Sanqi extract of Example 1, 750 g of the Astragalus extract of Example 1, and 300 g of Borneolum, and mix them uniformly to prepare the active ingredient of the present invention;

[0085] Preparation of masterbatch: Take a mixture of micropowder silica gel and chitosan with a weight ratio of 1:1 to pass through a 200-mesh sieve, 65% of which is used as a base material and put into the side spray pot of the fluidized bed, and another PVP K30 is added with water, extract, and prepared Adhesive forming agent-spray in as slurry, and sieve out small particles with a particle size of 120-180μ as the mother nucleus, then put the mother nucleus into the pot, continue to spray starch slurry, and at the same time, spray the remaining 35% from the powder gun The fine powder of micronized silica gel and chitosan is sprinkled in to make the partic...

Embodiment 3

[0088] Preparation of the active ingredients of the present invention: take 960 g of the salvia miltiorrhiza extract of Example 1, 1360 g of the Panax notoginseng extract of Example 1, 700 g of the Radix Astragali extract of Example 1, and 280 g of Borneolum, mix them uniformly, and prepare the prepared.

[0089] Preparation of masterbatch: take a mixture of dextrin and starch with a weight ratio of 1:1 and pass through a 200 mesh sieve, 65% of which is put into the side spray pot of the fluidized bed as the bottom material, and starch and extract (after being folded and dried to account for the mother batch) 15% of the grain weight) and water to make a slurry and spray it in, and sieve out small particles (180-250μ) as the mother nucleus, then put the mother nucleus into the pot, continue to spray the starch slurry, and at the same time, spray it from the powder gun Sprinkle the remaining 35% dextrin and starch fine powder to make the particle size of the mother core grow, and...

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PUM

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Abstract

The invention provides a traditional Chinese medicine granular preparation with astragalus extract and a preparation method thereof. Traditional Chinese medicine spheroidized particles are prepared by using a traditional Chinese medicine extract and a pharmaceutically acceptable carrier. The shapes of the traditional Chinese medicine spheroidized particles are spherical or similar to spheres, andthe density of the traditional Chinese medicine spheroidized particles ranges from 0.6 g / ml to 1.3 g / ml. A single dose of the spheroidized particles is small, the medicine taking is convenient, and the granular preparation can be used as a semifinished product of capsules and can also be used for developing sustained and controlled release preparations of traditional Chinese medicine.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a traditional Chinese medicine granule containing astragalus extract and a preparation method thereof. Background technique [0002] According to my country's epidemiological survey, the incidence and mortality of cardiovascular and cerebrovascular diseases have been on the rise in the past 50 years, whether in rural areas or cities. In the 1950s and 1960s, cardiovascular disease and cerebrovascular disease ranked fifth and sixth among the causes of death in my country, and rose to second and third respectively after 1975. Cardiovascular and cerebrovascular diseases accounted for the first place among all causes of death. The percentage of deaths due to cardiovascular and cerebrovascular diseases in the total death population in my country has risen from 12.07% in 1957 to 42.6% in 2001, and 2 million people died of cardiovascular and c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K36/481A61K36/537A61K47/04A61K47/36A61K47/38A61K47/40A61P9/10A61K31/045
Inventor 李永强郑永锋
Owner TIANJIN TASLY PHARMA CO LTD
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