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Bacterial inhibition biological active titanium and titanium alloy implantation material as well as preparation method and use thereof

An implant material and bioactive technology, applied in the field of bacteriostatic biomedical active titanium and titanium alloy implant materials and their preparation, biomedical materials and their preparation fields, can solve the failure of titanium implants, implant failures, etc. problems, to achieve the effect of improving the success rate, avoiding infection, and easy to use

Inactive Publication Date: 2009-06-10
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, bacterial infection of implants in vivo is still one of the main reasons for implant failure
According to reports, 3-5% of titanium implants currently fail due to bacterial infection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Biomedical grade titanium is used as the base material, and analytically pure hydrochloric acid is used as the raw material to add deionized water to prepare an electrolyte solution with a concentration of 1M chloride ions. The medical titanium is connected to the anode of the DC power supply used for anodizing, and the cathode It is also connected with medical titanium as the cathode of the anodic oxidation process; use analytically pure hydrochloric acid as the raw material and add deionized water to prepare a 5M aqueous solution, put the titanium into the 5M hydrochloric acid aqueous solution and soak for 3 minutes to remove surface pollutants, and then direct current The voltage of the power supply is adjusted to 60V, that is, apply a voltage of 60V, treat for 30 seconds, take out the medical titanium, and then clean it with deionized water to obtain antibacterial biological activity rich in Ti-Cl groups and Ti-OH groups on the surface titanium. These titanium rich ...

Embodiment 2

[0029] The biomedical grade titanium alloy is used as the base material, and analytically pure sodium chloride is used as the raw material to add deionized water to prepare an electrolyte solution with a concentration of 3M chloride ions. The medical titanium alloy is connected to the anode of the DC power supply used for anodizing treatment. The cathode of the power supply is also connected to a medical titanium alloy as the cathode of the anodic oxidation process; use analytically pure hydrochloric acid as a raw material and add deionized water to prepare a 2M aqueous solution, and put the titanium alloy into the 2M hydrochloric acid aqueous solution for 6 minutes to remove it. After surface contamination, put the cleaned titanium alloy into sodium chloride aqueous solution and apply a voltage of 45V for 60 seconds, take out the medical titanium alloy, clean it with deionized water, and obtain a surface rich in Ti-Cl groups and Ti- Bacteriostatic bioactive titanium alloys wit...

Embodiment 3

[0031] Biomedical grade titanium is used as the base material, analytically pure potassium chloride is used as the raw material, and deionized water is added to prepare an electrolyte solution with a concentration of 5M chloride ions. The medical titanium is connected to the anode of the DC power supply used for anodizing. The cathode is connected with medical titanium as the cathode of the anodic oxidation process; use analytically pure hydrochloric acid as a raw material and add deionized water to prepare a 1M aqueous solution, put the titanium into the 1M hydrochloric acid aqueous solution and soak for 7 minutes to remove surface pollutants, then put Put the cleaned titanium into potassium chloride aqueous solution and apply a voltage of 15V for 90 seconds, take out the medical titanium, wash it with deionized water, and obtain a bacteriostatic biological substance rich in Ti-Cl groups and Ti-OH groups on the surface. active titanium. These titanium rich in Ti-Cl groups and...

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PUM

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Abstract

The invention relates to bacteria inhibiting biological activity titanium, a titanium alloy implanting material, a method for preparing and application thereof. In the method, biological medical-class titanium or titanium alloy is used as base material, the matter of which analytical reagent contains chloride ion is added with deionized water to prepare electrolyte solution, with the adoption of a anode oxidation surface modification treatment technique, the DC voltage of between 1 and 100V is applied between an anode and a cathode of the material, and the treatment time is between 1 and 200 seconds; the biological activity titanium or titanium alloy with bacteria inhibiting Ti-Cl radicals and biological activity Ti-OH radicals generated on the surface is obtained, and the Ti-Cl groups are hydrolyzed to generate -ClOx ion with bacteria inhibiting and killing actions in the physiological environment. The material can be implanted in thigh bones of people and animals for restoring large segment bone defects, or applied to percutaneous devices of people and animals; because the implanted material has biological activity, the material can form the biological activity combination with tissues; and because the implanted material can inhibit bacteria, the material can avoid infection, thereby improving success ratio of implantation.

Description

technical field [0001] The invention relates to a biomedical material and its preparation technology, in particular to a bacteriostatic biomedical active titanium and titanium alloy implant material for hard tissue repair and its preparation method and application, belonging to the technical field of biomedical engineering. Background technique [0002] Biomedical titanium and titanium alloys are widely used in implants because of their excellent biocompatibility and physiological corrosion resistance. In recent years, titanium and titanium alloys have transformed typical inert medical titanium and titanium alloy materials into bioactive and tissue-inducing materials through the application of surface modification technology, which can induce tissue regeneration and repair in vivo. In the field of biomedical materials, titanium and titanium alloys will have wider application prospects. However, bacterial infection of implants in vivo is still one of the main causes of impla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D11/26A61L27/06
Inventor 杨帮成岳崇霞
Owner SICHUAN UNIV