Huperzine A capsule and preparation method thereof
A technology for huperzine A and capsules, which is applied in the field of huperzine A capsules and its preparation, and can solve problems such as difficult quality assurance
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Embodiment 1
[0026] prescription:
[0027] Huperzine A 0.1g
[0028] Mannitol 259.9g
[0029] 1.5% (W / V) citric acid solution appropriate amount
[0030] 0.5M sodium hydroxide solution appropriate amount
[0031] Mannitol (filler) appropriate amount
[0032] Preparation process: ① take 0.1g huperzine A raw material, dissolve it with 1.5% (W / V) citric acid solution, and set aside; ② take 260g mannitol and dissolve it in 1500L purified water or water for injection, set aside; ③ mix the two solution, and then use 0.5M sodium hydroxide solution to adjust the pH value of the mixed solution to 3.9, and fill it in a shallow dish; ④ Freeze-drying (pre-freezing, the temperature drops to -40°C, freeze for two hours, vacuumize, and then freeze at a rate of 1 minute Raise the temperature to 10°C at a heating rate of 0.2°C, keep the temperature for 5 hours, then raise the temperature to 30°C at a heating rate of 0.4°C per minute, and leave the box after 4 hours at a constant temperature); The cont...
Embodiment 2
[0034] prescription:
[0035] Huperzine A 13g
[0036] Sorbitol 247g
[0037] 5% (W / V) citric acid solution appropriate amount
[0038] 0.5M sodium hydroxide solution appropriate amount
[0039] Sorbitol (filler) appropriate amount
[0040] Process: ① Take 0.1g Huperzine A raw material, dissolve it with 5% (W / V) citric acid solution, and set aside; ② Take 260g sorbitol and dissolve it in 1500L purified water or water for injection, set aside; ③ Mix the two solutions , and then use 0.5M sodium hydroxide solution to adjust the pH value of the mixture to 4.0, and fill it in a shallow plate; ④ Freeze-drying (pre-freezing, the temperature drops to -40°C, freeze for two hours, vacuumize, and then 0.2 per minute ℃ heating rate to raise the temperature to 10 ℃, constant temperature for 5 hours, then raise the temperature to 30 ℃ with a heating rate of 0.4 ℃ per minute, keep the temperature for 4 hours and leave the box); ⑤ out of the box and pulverize; Alkaline A content, calcula...
Embodiment 3
[0042] prescription:
[0043] Huperzine A 5g
[0044] Xylitol 260g
[0045] 3% (W / V) citric acid solution appropriate amount
[0046] 0.5M sodium hydroxide solution appropriate amount
[0047] Mannitol, xylitol (filler) appropriate amount
[0048] Process: ①Take 0.1g huperzine A raw material, dissolve it with 3% citric acid solution, and set aside; ②Take 260g xylitol and dissolve it in 1500L purified water or water for injection, set aside; ③Mix the two solutions, and then use 0.5 M sodium hydroxide solution adjusts the pH value of the mixed solution to 4.0, and fills it in a shallow dish; ④ freeze-drying (pre-freezing, the temperature drops to -40°C, freezes for two hours, vacuumizes, and then heats up at a rate of 0.2°C per minute Raise the temperature to 10°C, keep the temperature constant for 5 hours, then raise the temperature to 30°C at a rate of 0.4°C per minute, and leave the box after 4 hours at a constant temperature); ⑤ go out of the box and pulverize; ⑥ measure...
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