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Antalgic gel patch and preparation method thereof

A patch and gel technology, which is applied in the field of transdermal absorption gel patch and its preparation, can solve the problems of high skin irritation, easy contamination of clothes, and large toxic and side effects

Inactive Publication Date: 2009-07-01
TIANJIN ZHONGBAO PHARMACY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The purpose of the present invention is to combine the advantages of the latest molecular gel and hydrogel, to overcome the common disadvantages of large toxic and side effects of existing oral preparations, and to avoid the poor plasticity of general water-based gels and skin irritation caused by oily gels. Disadvantages such as strong sex and easy to contaminate clothes

Method used

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  • Antalgic gel patch and preparation method thereof

Examples

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Embodiment

[0027] Penetration enhancer laurocapram, oleic acid 12kg

[0028] Molecular Gel 2.5% Lecithin,

[0029] 97.5 Isopropyl myristate 100kg

[0030] Hydrogel 8% Sodium Polyacrylate, 2% Polyvinylpyrrolidone

[0031] 2% sodium carboxymethylcellulose, 20% propylene glycol,

[0032] 20% glycerin, 48% deionized water 300kg

[0033] Licorice Extract 20kg

[0034]Peony Extract 25kg

[0035] Corydalis extract 20kg

[0036] Weigh 24kg of sodium polyacrylate, 6kg of polyvinylpyrrolidone and 6kg of sodium carboxymethylcellulose solid powder and mix them evenly, disperse them in 60kg of propylene glycol, 60kg of glycerin solvent, mix them evenly in a stirrer, add 20kg of licorice extract and 144L Deionized water, mix evenly, take 97.5kg of isopropyl myristate and put it in a blender, add 25kg of peony extract, 20kg of Corydalis extract and 12kg of a mixture of laurocapram and oleic acid, heat and stir at 60°C until completely mixed Finally, ad...

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Abstract

The present invention relates to an analgesic gel plaster and its preparation method, composed of 2%-100% of extract of traditional Chinese medicine and 98%-0% of medicinal adjuvant, wherein the enoxolone glycyrrhetinic acid crude product is extracted using repeat high-temperature digestion and extraction of glycyrrhiza; the fat-soluble components of paeonia lactiflora and corydlis tuber are extracted using alcohol extraction method. The traditional Chinese medicine plaster is prepared by mixing the molecule gel with the hydrogel and the water-soluble medicine enters into the skin through a water-based channel and the fat-soluble medicine enters into the skin by a fat-soluble channel, thus the production technique prevents the separation of medicine and matrix, at the same time a certain repulsion force of oil-based matrix to the water-based medicine and a certain repulsion force of water-based matrix to the oil-based medicine can promote the medicine absorption and the medicine efficacy is increased.

Description

technical field [0001] The invention relates to the newest molecular gel dosage form and hydrogel dosage form in the technical field of transdermal drug delivery preparations, a transdermal absorption gel patch for treating pain with traditional Chinese medicine extracts and a medicinal matrix and a preparation method thereof. Background technique [0002] Pain is a symptom of many diseases. It makes patients feel pain, especially severe pain, and may also cause physiological dysfunction and even shock. Therefore, it is necessary to apply drugs appropriately to relieve pain and prevent possible physiological dysfunction. Analgesics are drugs that act primarily on the central nervous system and selectively inhibit pain sensation. Most of them are opioids (such as morphine) and their synthetic products (such as pethidine, analgesic, etc.), which can relieve sharp pains such as fractures and burns (this is the difference from antipyretic and analgesics), and they are used cont...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K9/70A61K47/10A61K47/12A61K47/14A61K47/18A61K47/32A61K47/38A61P25/04
Inventor 高惠明方昊周英超李扬
Owner TIANJIN ZHONGBAO PHARMACY