Unlock instant, AI-driven research and patent intelligence for your innovation.

Microbial drug material, its preparing method and usage

A production method and a technology of raw materials, applied in the direction of antineoplastic drugs, pharmaceutical formulations, medical raw materials derived from fungi, etc., can solve the problems of bioavailability to be improved, and achieve good clinical application effects, safe use, and good synergy Effect

Inactive Publication Date: 2006-06-28
许景三
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the main bioactive selenium in the market is natural yeast selenium, but its bioavailability needs to be improved

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] 1. Preparation of Bioactive Selenium

[0046] Add 0.3g of yeast extract, 5g of sodium acetate, 1g of ammonium oxide, 1g of potassium dihydrogen phosphate, 0.5g of magnesium oxide, and 3g of sodium bicarbonate into 1000ml of distilled water, stir and dissolve, boil for sterilization, and reduce the humidity to 32°C and press 5wt% The proportion of Rhodopseudomonas (Rhodopseudomonas), especially Rhodopseudomonas sanguinus (Rhodopseudomonas palustris, Rps.Rutila), cultured in a solar wet room at 25°C-26°C for 3 days, then added 200mg / kg concentration of sodium selenite continued to cultivate for 5 days, and the material gradually turned dark red, indicating that it had matured. Sampling and testing showed that the number of live bacteria was 1.0-1.1 billion / ml.

[0047] 2. Preparation of Fungal Polysaccharides

[0048] Select 1000g of the fresh fruiting body of the natural edible fungus Flammulina velutipes, add edible alcohol according to 20 times the amount, extract a...

Embodiment 2

[0053] 1. Preparation of Bioactive Selenium

[0054] Add 1g of yeast extract (brewer's yeast Brewer'Sreast), 3g of sodium acetate, 5g of ammonium oxide, 3g of potassium dihydrogen phosphate, 0.1g of magnesium oxide, and 1g of sodium bicarbonate into 1000ml of distilled water, stir to dissolve, boil to sterilize, and dehumidify After reaching 32 DEG C, insert Rhodospirilium bacterial classification in the ratio of 10wt%, bacterial classification is 0192 (Rhodospirilium1 altogether 1 strains), put solar greenhouse 29 DEG C-30 DEG C after cultivating for 2 days, add the selenous acid of 500mg / kg concentration For cobalt, continue to cultivate for 3 days, and the material gradually turns dark red, indicating that it has matured. Sampling and detection, the number of viable bacteria can generally reach 1.9-2 billion / ml.

[0055] 2. Preparation of Fungal Polysaccharides

[0056] Select 1000g of fresh fruiting body of Flammulina velutipes, 10 times the amount of selected natural ed...

Embodiment 3

[0060] 1. Preparation of Bioactive Selenium

[0061] Add 0.1g of yeast extract, 1g of sodium acetate, 0.1g of ammonium oxide, 5g of potassium dihydrogen phosphate, 3g of magnesium oxide, and 10g of sodium bicarbonate into 1000ml of distilled water, stir and dissolve, boil for sterilization, and reduce the humidity to 32°C and press 8wt% The proportion of Rhodopseudomonas strains (Rhodopseudomonas globosa Rps.Globiformis) was inserted, and after cultivating for 2.5 days in a solar wet room at 28°C-29°C, calcium selenite at a concentration of 500mg / kg was added, and the cultivation was continued for 3 Days, the material gradually turns dark red, indicating that it has matured. Sampling and detection, the number of viable bacteria can generally reach 1.9-2 billion / ml.

[0062] 2. Preparation of Fungal Polysaccharides

[0063] Select 1000g of fresh fruiting body of Flammulina velutipes, add 15 times the amount of edible alcohol, leaching at room temperature (30°C) until pectin i...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a selenium-containing microbiological preparation for treating cancer, wherein the newly screened bacterial is employed for carrying out fermentation to inorganic selenium, so as to transform into nontoxic biological selenium, then composite fermentation is carried out with granulose extracted from natural edible mushrooms. The prepared granulose has higher synthesis effect and better clinical application result.

Description

technical field [0001] The invention relates to a microbial raw material medicine and a production method thereof, in particular to an anticancer raw material medicine containing biological selenium produced by microbial fermentation and a production method thereof. Background technique [0002] Selenium is an essential trace element for the human body, and the level of selenium in human blood is directly related to human health. Modern medical research shows that selenium is a powerful antioxidant in the human body and can also regulate the absorption of vitamins A, C, and E in the human body. Selenium deficiency is closely related to diseases such as cancer, cardiovascular and cerebrovascular diseases, and human aging. At present, the per capita selenium intake of adults in our country should be 50-200 μg per day. If the daily intake of human body is lower than 50 μg for a long time, it will induce many serious diseases. [0003] The daily diet contains very little selen...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715A61K36/06A61P35/00C12N1/14C12P19/04
Inventor 伍智文汤珍山
Owner 许景三