Veramyst medicinal preparation and preparation method

A technology of fluticasone furoate and pharmaceutical preparations, which is applied in the field of medicine and its preparation, and achieves the effects of fast curative effect, high efficiency and small side effects

Inactive Publication Date: 2009-07-08
崔晓廷
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

After a patent search, the patent declaration of flutic

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Fluticasone furoate gel spray for allergic rhinitis

[0020] prescription:

[0021] Fluticasone furoate 0.05%, gellan gum 0.02%, Tween-803%, methylcellulose 3%, thimerosal 0.01%, glycerin 30%, propylene glycol 10%, and the remaining content is purified water.

[0022] Preparation method:

[0023] 1. Add fluticasone furoate micropowder into Tween-80 aqueous solution to disperse the drug evenly.

[0024] 2. Take another container and add appropriate amount of pure water, add thimerosal and gellan gum successively and stir to dissolve. Then add fluticasone furoate micropowder-Tween-80 aqueous solution, methylcellulose, glycerin, propylene glycol, and purified water to the total amount. Stir well to mix.

[0025] 3. Adjust the pH to 4-7, pack into spray bottles, and perform quality inspection to obtain fluticasone furoate gel spray.

[0026] Effect:

[0027] It is safe and effective to treat perennial and seasonal allergic rhinitis with this product. Through the anti...

Embodiment 2

[0029] Fluticasone furoate liniment for atopic eczema

[0030] prescription:

[0031] A: Phellodendron 50g, Sophora flavescens 65g, Pepper 45g, Gallnut 80g

[0032] B: Fluticasone furoate 1g, Tween-800.05g, ethanol 100g, glycerin 120g, carbomer 3g, purified water to a total of 1000ml.

[0033] Preparation method:

[0034] 1. Decoct the traditional Chinese medicine of group A with 5 times the amount of water twice, each time for 2 hours, combine the filtrates, and precipitate the concentrated solution with 75% ethanol for 18 hours, recover the ethanol until it has no alcohol smell, and obtain the extract of group A for later use.

[0035] 2. Add fluticasone furoate micropowder into Tween-80 aqueous solution to disperse the drug evenly.

[0036] 3. Take another container and add an appropriate amount of pure water, add carbomer and stir to dissolve.

[0037] 4. Add the Tween-80 solution containing fluticasone furoate micropowder into the carbomer solution and stir evenly, th...

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PUM

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Abstract

The invention provides a single preparation and compound preparation using furoic acid fluticasone as main constituent. The weight ratio of furoic acid fluticasone in pharmaceuticals is 0.0001-50%. The pharmaceuticals can be made into jellies, supensoid agent, liquor and pulvis, and the like, which are administrated in a percutaneous way. The preparation is suitable for anaphylactic rhinitis, asthma and stubborn skin disease. The invention has the advantages of high healing rate, high safety and high promotional value.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, more specifically relates to a fluticasone furoate pharmaceutical preparation and a preparation method, and belongs to the technical field of medicine and its preparation. Background technique [0002] Allergic upper respiratory diseases and skin diseases are a large class of diseases that endanger human health. Especially allergic rhinitis, asthma and intractable skin diseases such as dermatitis, eczema, vitiligo, psoriasis, hives, lupus erythematosus, lichen planus, etc. have a high incidence rate, long course and greater harm. The pathogenesis of most of these diseases is not completely clear, protracted and refractory, and the recurrence rate is high, which brings great pain to the patient's body and causes heavy psychological and economic burdens. [0003] Treatment methods for such diseases: oral Chinese and Western medicines, external administration, surgery, physical therapy, etc. Althoug...

Claims

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Application Information

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IPC IPC(8): A61K31/58A61P43/00A61P37/08A61P11/02A61P11/06A61P17/00A61K9/00
Inventor 王悦
Owner 崔晓廷
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