Pharmaceutical composition for treating acute and chronic nasal sinusitis and preparation method thereof

A composition and a technique for sinusitis, which are applied in the field of pharmaceutical compositions for treating acute and chronic sinusitis and their preparation fields, can solve the problems of unsatisfactory effects of mucopurulent secretions, affecting local antibacterial treatment, adverse reactions, etc. Low degree of absorption, less resistant to antibiotics, and the effect of relieving clinical symptoms

Inactive Publication Date: 2009-07-15
SHENZHEN QI WANG INVESTMENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Intravenous or oral administration of antibiotics, the problem is that the blood concentration of the systemic drug is high and the blood concentration of the sinus infection is low, which affects local antibacterial treatment on the one hand, and easily leads to bacterial drug resistance and systemic adverse reactions on the other hand
For example, the co

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 Ambroxol hydrochloride and ciprofloxacin composition

[0026] Get ambroxol hydrochloride and ciprofloxacin appropriate amount, accurately weighed, add 0.9% sodium chloride injection dilution, make the solution containing ambroxol hydrochloride concentration that is 0.003% and ciprofloxacin concentration is 0.01%, filter , divided into infusion bottles of different volumes, sterilized, and obtained.

Embodiment 2

[0027] Embodiment 2 Ambroxol hydrochloride and ciprofloxacin composition

[0028] Get ambroxol hydrochloride and ciprofloxacin appropriate amount, accurately weighed, add 5% glucose injection dilution, make the solution that the ambroxol hydrochloride concentration is 0.003% and the ciprofloxacin concentration is 0.01%, filter, divide Packed in infusion bottles of different volumes and sterilized to obtain the product.

Embodiment 3

[0029]Embodiment 3 Ambroxol hydrochloride and levofloxacin hydrochloride composition

[0030] Take appropriate amount of ambroxol hydrochloride and levofloxacin hydrochloride, accurately weighed, add 0.9% sodium chloride injection to dilute to make a solution containing 0.006% ambroxol hydrochloride and 0.06% levofloxacin hydrochloride, filter, and pack in different volumes of infusion solution bottle, sterilized, that is.

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PUM

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Abstract

The invention discloses a pharmaceutical composition for curing chronic nasosinusitis and a preparation method thereof. The pharmaceutical composition contains phlegm-resolving prescription ambroxol hydrochloride and antibiotics which is one of Beta- lactam, aminoglycoside, macrolide, carbostyril, anti-anaerobe and lincomycin, or mixture of one of the antibiotics except the anti-anaerobe and the anti-anaerobe. The composition adopts a sinuses irrigation method to administrate and has the characteristics of convenient use, good validity, high safety and hard recurrence for the cure of the acute nasosinusitis and the chronic nasosinusitis.

Description

technical field [0001] The invention relates to a pharmaceutical composition composed of ambroxol hydrochloride, a phlegm-reducing agent, and antibiotics, which is used for treating acute and chronic sinusitis by flushing. Background technique [0002] Sinusitis is a common disease, a frequently-occurring disease, and a difficult disease in rhinology. The so-called sinuses are the air-containing cavities of the facial skull around the nasal cavity; there are 4 pairs on the left and right: the frontal sinus, the maxillary sinus, the ethmoid sinus, and the sphenoid sinus. Because of its anatomical characteristics, each sinus can develop separately, and can also form polynasal sinusitis or pannasinusitis. Primary disease refers to the non-specific inflammation of nasal sinus mucous membrane, is generally divided into two types of acute and chronic, investigates its reason a lot, more complicated. Acute sinusitis is mostly caused by acute rhinitis, and is characterized by nasa...

Claims

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Application Information

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IPC IPC(8): A61K31/137A61K45/06A61P11/02A61K31/5383A61K31/496A61K31/7052A61K31/7048
Inventor 曲敬来刘玉玲温纯青温育青刘家琛曾晓莲高雪
Owner SHENZHEN QI WANG INVESTMENT
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