Pharmaceutical composition for treating acute and chronic nasal sinusitis and preparation method thereof

Abstract

The invention discloses a pharmaceutical composition for curing chronic nasosinusitis and a preparation method thereof. The pharmaceutical composition contains phlegm-resolving prescription ambroxol hydrochloride and antibiotics which is one of Beta- lactam, aminoglycoside, macrolide, carbostyril, anti-anaerobe and lincomycin, or mixture of one of the antibiotics except the anti-anaerobe and the anti-anaerobe. The composition adopts a sinuses irrigation method to administrate and has the characteristics of convenient use, good validity, high safety and hard recurrence for the cure of the acute nasosinusitis and the chronic nasosinusitis.

Description

technical field [0001] The invention relates to a pharmaceutical composition composed of ambroxol hydrochloride, a phlegm-reducing agent, and antibiotics, which is used for treating acute and chronic sinusitis by flushing. Background technique [0002] Sinusitis is a common disease, a frequently-occurring disease, and a difficult disease in rhinology. The so-called sinuses are the air-containing cavities of the facial skull around the nasal cavity; there are 4 pairs on the left and right: the frontal sinus, the maxillary sinus, the ethmoid sinus, and the sphenoid sinus. Because of its anatomical characteristics, each sinus can develop separately, and can also form polynasal sinusitis or pannasinusitis. Primary disease refers to the non-specific inflammation of nasal sinus mucous membrane, is generally divided into two types of acute and chronic, investigates its reason a lot, more complicated. Acute sinusitis is mostly caused by acute rhinitis, and is characterized by nasa...

AI Technical Summary

Problems solved by technology

Intravenous or oral administration of antibiotics, the problem is that the blood concentration of the systemic drug is high and the blood concentration of the sinus infection is low, which affects local antibacterial treatment on the one hand, and easily leads to bacterial drug resistance and systemic adverse reactions on the other hand

For example, the commonly used nasal cavity washing solution composed of chymotrypsin as the main component can digest and remove blood clots, purulent secretions and necrotic tissues to a certain extent, but it has no effect on mucus purulent secretions in the nasal cavity. Very satisfied, therefore, this product is mostly used in ophthalmic surgery and wound inflammation