24-methylene cycloartenyl ferulate composition and method for preparing the same
A technology of pineapple alcohol ferulate and methylene ringwood, applied in the field of medicine, can solve the problems of muscle agglomeration, slow onset of action, insoluble oryzanol in water, etc.
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Embodiment 1
[0041] 24-Methylenecycloartenol Ferulate 10mg
[0042] Soy Lecithin 50mg
[0043] Glycoursodeoxycholic Acid 50mg
[0044] Glycine 50mg
[0045] Water for injection to 10ml
[0046] Dissolve 24-methylenecycloartenol ferulate, soybean lecithin, and ursodeoxycholic acid in 5ml of ethyl acetate, heat to 80°C and stir until fully dissolved. Distilled by evaporation under reduced pressure to obtain an organic phase. Add water for injection in which glycine has been dissolved to the full amount in the organic phase, and stir well at 60°C to obtain the injection solution of the present invention. Adjust the pH to 7.2 with sodium hydroxide solution, add 0.05% activated carbon for injection and stir for 30 minutes, after decarburization and filtration, perform fine filtration with a 0.22um microporous filter membrane, and pack into vials.
Embodiment 2
[0048] 24-Methylenecycloartenol Ferulate 10mg
[0049] Soy Lecithin 1000mg
[0050] Phosphatidylcholine 100mg
[0051] Chenodeoxycholic Acid 400mg
[0052] Mannitol 100mg
[0053] Water for injection to 10ml
[0054] Dissolve 24-methylene cycloartenol ferulate, chenodeoxycholic acid, soybean lecithin, phosphatidylcholine, and mannitol in 8ml of propylene glycol, heat to 80°C and stir until fully dissolved. Distilled by evaporation under reduced pressure to obtain an organic phase. Add water for injection to the organic phase to the full amount, and fully stir and mix at 70°C to obtain the injection solution of the present invention. Adjust the pH to 7.0 with sodium hydroxide solution, add 0.05% activated carbon for injection and stir for 30 minutes, after decarburization and filtration, perform fine filtration with a 0.22um microporous filter membrane, and pack into vials.
Embodiment 3
[0056] 24-Methylenecycloartenol Ferulate 20mg
[0057] Soy sphingomyelin 100mg
[0058] Taurodeoxycholic Acid 200mg
[0059] Glucose 100mg
[0060] Water for injection to 10ml
[0061] Dissolve 24-methylene cycloartenol ferulate, soybean sphingomyelin, and taurodeoxycholic acid in 10ml of glycerol, heat to 80°C and stir until fully dissolved. Distilled by evaporation under reduced pressure to obtain an organic phase. Add water for injection in which glucose has been dissolved to the full amount in the organic phase, and fully stir and mix at 60° C. to obtain the injection solution of the present invention. Adjust the pH to 6.5 with sodium bicarbonate solution, add 0.05% activated carbon for injection and stir for 30 minutes, after decarburization and filtration, perform fine filtration with a 0.22um microporous filter membrane, and pack into vials.
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