Drug delivery system and preparation method thereof

Abstract

The invention belongs to the technical field of medicines, and discloses a delivery system based on protein-phospholipid. The system comprises a protein-phospholipid dispersion with the weight ratio of between 1:100 and 100:1, wherein the grain size of the protein-phospholipid is between 5 and 1,000nm, and the surface of the phospholipid or the surface and the inside of the phospholipid are coated / covered by a protein layer. The preparation method comprises: preparing a phospholipid containing phase, preparing a protein containing water phase, performing the homogenization treatment on the phospholipid containing phase and the protein containing water phase at a temperature of between 0 and 40 DEG C and under a pressure of between 400 and 40,000psi, and obtaining a dispersion system with the average grain size of less than 1,000nm. The delivery system has the advantages of realizing the delivery in various ways such as injection, oral taking, cavities and canals, skin and the like, and lowering side effects of medicines. The delivery system solves the problems of drug-loading rate and stability of protein nano-grain and liposome, and adopts low-toxicity organic solvent, even no organic solvent; and the preparation method is easy for industrialized application, and can prepare a liquid type protein-phospholipid containing delivery system.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, more specifically to a drug delivery system and a preparation method thereof. Background technique [0002] In recent years, with the rapid development of drug therapy, the concept of "optimization of drug use" has gradually become a matter of great concern to people. This is mainly to reflect the value of drug therapy reasonably and ensure the safety of drug therapy. [0003] By using new technologies and methods to regulate the dynamic changes of drugs in the body to obtain the best therapeutic effect, this is the drug delivery system (DDS). Utilizing the function of the drug delivery system can improve the absorption of drugs, reduce the toxic and side effects of drugs, increase the distribution of drugs in diseased tissues, and achieve the purpose of increasing efficiency and reducing toxicity. [0004] In the field of pharmacy, the size of nanoparticles is generally defined as 1-1...

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Problems solved by technology

[0009] Although liposome has its outstanding advantages, there are also some unresolved problems: as (1) the stability of liposome drug is not high; (2) liposome encapsulation efficiency and drug loading are low, for A kind of specific medicine will prepare a kind of comparatively desirable liposome, usually all will do a large amount of screening work; (3) the medicine that is suitable for liposome is also limited; (4) generally will use a large amount of liposomes in the preparation process Toxic solvent; (5) Ordinary liposomes are mainly concentrated in organs rich in reticuloendothelial cells, and cannot recognize caveolin on vascular endothelium

[0011] In addition, the side effects that exist during the administration process mainly include venous irritation, phlebitis, pain, bone marrow suppression, neurotoxicity, allergies, inflammation, skin irritation, etc., which are important issues that must be considered when researching and developing new drug delivery systems. question

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