Preparation method of Qingpeng plaster

A technology of Qingpeng ointment and ointment, which is used in medical preparations containing active ingredients, anti-inflammatory agents, anti-viral agents, etc. problems, to achieve the effect of overcoming the inability to industrialize production, improving bioavailability, and solving the problem of transdermal absorption

Inactive Publication Date: 2009-07-29
GANSU CHEEZHENG TIBETAN MEDICINE CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The preparation process of the traditional Tibetan medicine Qingpeng ointment is to mix all the original medicinal materials into an ointment. The process is complicated, the batch production cycle is long, and the production process is unstable; the source of raw materials and excipients is unstable, which is not conducive to industrial production; some drugs penetrate The ability is poor, the bioavailability is low, the curative effect cannot be fully guaranteed, and it is not easy to exert the curative effect of the drug; in addition, the product is not easy to store and is inconvenient to carry; due to various reasons, the curative effect and promotion of the product are greatly affected

Method used

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  • Preparation method of Qingpeng plaster
  • Preparation method of Qingpeng plaster
  • Preparation method of Qingpeng plaster

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0159] A. With Oxytropis 100g, subrhubarb 50g, iron bar hammer 75g, myrobalan 100g, myrobalan 100g, emblical 100g, benzoin 35g and vine vine 150g, mix uniformly;

[0160] B. Weigh 50% of the total amount of the above-mentioned mixed raw materials, decoct 3 times at 85°C with 2.13kg of water, and decoct for 2 hours each time, collect the extract and volatile oil respectively; filter and concentrate the extract to the relative Concentrate with a density of 1.0-1.5; add volatile oil to the concentrate;

[0161] C. Grinding the above-mentioned remaining mixed raw materials into 100 μm powder, mixing with the above-mentioned concentrated solution containing volatile oil to obtain a mixed solution a; adding the mixed solution a to 50 times the weight of water, and stirring evenly to obtain a mixed solution b;

[0162] D. Mix the mixed liquid b with liquid paraffin and polysorbate-80 in a weight ratio of 2:1:1, and emulsify to obtain an emulsified paste;

[0163] E. Add 25g of musk ...

Embodiment 2

[0165] A. 115g of Oxytropis chinensis, 35g of subrhubarb, 55g of iron rod hammer, 115g of myrobalan, 85g of myrobalan, 115g of emblica, 45g of benzoin and 135g of vine vine are purified and mixed uniformly;

[0166] B. Weigh 20% of the total amount of the above-mentioned mixed raw materials, decoct 2 times at 90°C with 2.52kg of water, and decoct for 2.5 hours each time, collect the extract and volatile oil respectively; filter and concentrate the extract to the relative Concentrate with a density of 1.0-1.5; add volatile oil to the concentrate;

[0167] C. Grinding the above-mentioned remaining mixed raw materials into medicament powder of 1 μm, mixing with the above-mentioned concentrated solution containing volatile oil to obtain a mixed solution a; adding the mixed solution a to 5 times the weight of propylene glycol, and stirring evenly to obtain a mixed solution b;

[0168] D. Mix the mixed solution b with the oil phase and emulsifier in a weight ratio of 100:90:2, and e...

Embodiment 3

[0171] A. 85g of Oxytropis chinensis, 65g of subrhubarb, 95g of iron bar hammer, 85g of myrobalan, 115g of myrobalan, 85g of emblica, 25g of benzoin and 165g of vine vine are purified and mixed evenly;

[0172] B. Weigh 90% of the total amount of the above-mentioned mixed raw materials, decoct 3 times at 80°C with 6.48kg of water, decoct for 1 hour each time, collect the extract and volatile oil respectively; filter, concentrate the extract to the relative Concentrate with a density of 1.0-1.5; add volatile oil to the concentrate;

[0173] C. Grinding the above-mentioned remaining mixed raw materials into 180 μm drug powder, mixing with the above-mentioned concentrated solution containing volatile oil to obtain a mixed solution a; adding the mixed solution a to 90 times the weight of glycerol, and stirring evenly to obtain a mixed solution b;

[0174] D. Mix the mixed liquid b with the oil phase and emulsifier in a weight ratio of 100:1:90, and emulsify to obtain an emulsifie...

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Abstract

The invention discloses a method for preparing a qingpeng plaster. In the preparation process, firstly, one part of raw material drugs is decocted, extracted and condensed to obtain a condensed solution; secondly, the residual raw material drugs are pulverized, mixed with the condensed solution, emulsified and added with muskiness to finally obtain the qingpeng plaster. Compared with the prior art, the method for preparing the pingpeng plaster has the following advantages that: a prepared product has a stable process and high quality, stores active components of the drugs, improves the content and yield of a crude drug composition, solves the problem of percutaneous absorption, has quick effect, prolongs the storing time of the drug, is convenient to use and carry and improves the bioavailability of the product; and through technological innovation, the production process is simple, feasible and easy for industrialization and overcomes the disadvantages that an original product cannot be put into industrialized production.

Description

technical field [0001] The invention relates to a preparation method of a pharmaceutical composition, in particular to a preparation method of Tibetan medicine Qingpeng Ointment. Background technique [0002] Qingpeng ointment is a classic Tibetan medicine prescription composed of Tibetan folk doctors based on the records of "Tibetan Medicine and Supplements" and "Four Medical Codes", combined with practical experience. The prescription is included in the 95th edition of "Drug Standards issued by the Ministry of Health" The first volume of medicine, 322 pages. The prescription of Qingpeng ointment is: Oxytropis falciparum 100g, subrhubarb 50g, iron rod hammer 75g, chebula 100g, chebula 100g, emblica 100g, benzoin 35g, vine vine 150g, musk 25g, the preparation method recorded Method: the above nine flavors, except musk, which is ground into fine powder, the rest are ground into fine powder, sieved, added musk fine powder, mixed evenly, mixed with 8-year-old child urine, lard...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/714A61K9/06A61P19/06A61P29/00A61P31/22A61K35/55A61K31/122
Inventor 贺国杰张樱山刘海龙陈丽娟
Owner GANSU CHEEZHENG TIBETAN MEDICINE CO LTD
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