Particles for delivery of active ingredients, process of making and compositions thereof

A technology of active ingredients and compositions, applied in the field of active ingredient delivery, which can solve the problems of undescribed active ingredient delivery and achieve the effect of high surface area

Inactive Publication Date: 2009-08-05
PANACEA BIOTEC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patent does not describe inorganic nanostructures containing release rate modifiers prepared by sol-gel method for the delivery of active ingredients to topical and mucosal tissues

Method used

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  • Particles for delivery of active ingredients, process of making and compositions thereof
  • Particles for delivery of active ingredients, process of making and compositions thereof
  • Particles for delivery of active ingredients, process of making and compositions thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0119] Table 1

[0120] Element A B C D Terbinafine Hydrochloride 1.5g 1.5g 1.5g 1.5g Hydroxypropyl Cellulose

(HPC) 300mg 300mg 300.0mg -

Zinc nitrate hexahydrate 22.31g - 22.3g 22.3g Zinc acetate dihydrate - 25.5g - - Potassium hydroxide 8.4g 15.1g

(in 50g methanol) 8.4g 8.4g Methanol 75g 100g 60.0g 60.0g water 75g - 90.0g 90.0g

[0121] Method for 'A'

[0122] The metal oxide nanoparticles were obtained as follows: firstly zinc nitrate was dissolved in 50 g of water, and in another solution potassium hydroxide was dissolved in 25 g of water; after these two steps, terbinafine hydrochloride and hydroxyl Propylcellulose was dissolved in methanol to form solution 'A'. The previously prepared potassium hydroxide solution was added dropwise to solution 'A' under continuous stirring for about 20 minutes to form dispersion solution 'B'. The previously prepared zinc nitrate solution was a...

Embodiment 2

[0140] table 3

[0141] Element E F G H I Aciclovir 1.5g 1.5g 1.5g 1.5g 1.5g gum arabic - - 4.0g - - Mannitol - 44.0g - - - Potassium Hydroxide (KOH) 8.4g - - - - sodium hydroxide

(NaOH) _ 4.0g 4.0g 4.0g 4.0g Zinc nitrate hexahydrate 22.3g 14.87g 14.87g 14.87g 14.87g water 175g 200g 175g 150.0g 150.0g HPC-L 300mg 300.0mg 300.0mg 300.0mg -

[0142] method for E

[0143] Dissolve acyclovir together with potassium hydroxide in 50 g of water, then dissolve zinc nitrate in 50 g of water. Dissolve HPC independently in 75 grams of water. In addition, the three solutions were simultaneously mixed under stirring to obtain a white precipitate, which was lyophilized to obtain a white powder.

[0144] method for F

[0145] Mannitol was dissolved in 100 grams of water to form solution 'A'. Separately, acyclovir and NaOH were dissolved in 50 grams of water to form solution 'B'. In ...

Embodiment 33

[0167] table 5

[0168] Sample serial number Element J K L 1 gum arabic 4.0g _ - 2 pure water 75.0g - _ 3 Hydroxypropyl Cellulose 300.0mg 300.0mg _ 4 Zinc nitrate hexahydrate 14.87g 14.87g 14.87g 5 clindamycin phosphate 1.0g 1.0g 1.0g 6 pure water 50.0g 75.0g 75.0g 7 sodium hydroxide 4.0g 4.0g 4.0g 8 pure water 50.0g 75.0g 75.0g

[0169] Methods for J, K and L

[0170] Gum arabic was dissolved in 75.0 grams of purified water to form solution 'A', and hydroxypropyl cellulose and zinc nitrate were dissolved in purified water to form solution 'B'. In another step, the active molecule clindamycin was dissolved in an alkaline solution of sodium hydroxide to form solution C. Separately, solutions A, B, C (for method 'J') or solutions B, C (for method 'K') were mixed with continuous stirring at a controlled rate (0.2-0.5 ml / min) to form Dispersions. The dispersion was lyophilized to form a...

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Abstract

The present invention discloses compositions having particles comprising, inorganic element; one or more active ingredient and optionally a release rate modulating agent, suitable for the delivery of active ingredients to human and animal tissues. The particles are nanoparticles or microparticles or mixtures thereof, made preferably by sol-gel method. The compositions are useful for application to the topical or mucosal surfaces preferably in the form of creams, gels, lotions, dry powders, spray, foam and other suitable forms.

Description

technical field [0001] The present invention relates to the field of active ingredient delivery. The present invention relates to particles for the delivery of active ingredients in mammalian systems, methods for their preparation and compositions thereof. More precisely, the present invention relates to microparticles and nanoparticles for topical and mucosal surface delivery of active ingredients. Background technique [0002] Modern drug delivery technologies have resulted in complex systems that allow targeted and controlled release of active ingredients within mammalian systems. Delivery systems on the nanoscale scale offer efficient and less risky solutions to many drug delivery challenges. They can be used to target highly specific sites of action and, due to their small size, can be used for delivery to tissues that are difficult to reach with more conventional delivery agents. Polymer-based nanoparticles are well known for such systems. However, they use expensi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B82B3/00A61K9/51A61K9/00A61K47/30
CPCB82Y5/00A61K9/5115A61K9/19A61K9/5192A61K9/5161A61P3/10A61P11/06A61P17/00A61P17/06A61P17/10A61P19/02A61P25/24A61P31/10A61P31/12A61P33/10A61K9/14A61K33/00A61K33/30
Inventor 阿马尔吉特·辛格塞尔伯吉特·辛格帕兰姆吉特·辛格拉杰什·贾殷
Owner PANACEA BIOTEC
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