Slow-release patch with daphne giraldii bark extract, and preparation method thereof

Abstract

The invention belongs to the technical field of medicament, and discloses a percutaneous slow-release patch with a daphne giraldii bark extract, and a reparation method thereof. The patch with the daphne giraldii bark extract comprises a back lining layer, a drug reservoir and an antisticking layer, wherein the drug reservoir consists of the daphne giraldii bark extract, pressure sensitive adhesive and a percutaneous absorption accelerator; plasticizer, tackifier and antioxidant and the like can be added if needed; the selected pressure sensitive adhesive is silicone pressure sensitive adhesive, isobutylene pressure sensitive adhesive or acrylate pressure sensitive adhesive, and can select one or more compounds therein. The percutaneous patch has the advantages that the percutaneous patch can prevent oral administration from causing liver first-pass effect and irritating gastrointestinal tracts, overcomes deficiency that ointment, plaster, liniment, cream and other preparations are uncertain in dosage, easy to pollute clothes and the like, is constant in drug-releasing speed, ensures lasting steady therapeutic effect, and is convenient to use, good in flexibility and suitable in adhesion. The 24-hour accumulated permeation amount of daphnetin in a daphne giraldii bark patch prepared by the method is obviously higher than that of the commercially available daphne giraldii bark plaster.

Description

Technical field: [0001] The invention belongs to the technical field of medicine, and relates to a slow-release patch of Zushima extract and a preparation method thereof. The slow-release patch can treat pain and swelling caused by periarthritis of the shoulder, arthritis, low back pain, bruises, etc. . Background technique: [0002] Arthritis, frozen shoulder, low back pain, and bruises are multiple and widespread diseases with a high incidence rate and a wide range of people. According to the statistics of the World Health Organization, the incidence rate of arthritis among people over 55 years old is 80%. In 1999, the World Health Organization listed arthritis, cardiovascular disease and cancer as the three major killers threatening human health. As the saying goes: "Crawling all over the ground in pain, you can't do without Patriarch Ma." Patriarch Ma Xin warms the liver, reduces swelling and relieves pain, activates blood and dredges collaterals, and is a long-used p...

AI Technical Summary

Problems solved by technology

The detoxifying Zushima extract is made by decocting Zushima with ginger, licorice and other herbs. The crude extract of Zushima has not been separated and purified by modern technology. In addition, due to the use of sprays, gels, etc. Some insurmountable problems must be sprayed and rubbed frequently, and then the solvent volatilizes, and the drug is exposed to the skin surface. Not only is the drug easy to precipitate and crystallize, but it is also easy to be wiped off by clothes, resulting in insufficient drug dosage and unstable curative effect.