Method for extracting alpha-mangostin from mangosteen fruit peel

A technology of mangostin and mangosteen peel, applied in the direction of pharmaceutical formula, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of complex process, low yield, long operation time, etc., and achieve simple process and high yield High, short operation time effect

Active Publication Date: 2012-08-22
SHAANXI JIAHE PHYTOCHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The object of the present invention is to provide a method for extracting α-mangostin from mangosteen peel, which solves the problems of complex process, long operation time and low yield in the background technology

Method used

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  • Method for extracting alpha-mangostin from mangosteen fruit peel
  • Method for extracting alpha-mangostin from mangosteen fruit peel
  • Method for extracting alpha-mangostin from mangosteen fruit peel

Examples

Experimental program
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Embodiment 1

[0065] Take 100 kg of mangosteen peel, wash and crush it, add 5 times the volume of 50% ethanol, extract 3 times at 90°C for 2 hours each time, and collect the first, second and third extraction liquids respectively, and pass each extraction liquid through centrifuge, filter, combine, and under the conditions of temperature of 60°C and pressure of 0.06MPa, concentrate under reduced pressure until there is no alcohol smell to obtain a concentrated solution, add 5 times the volume of ethyl acetate to extract the concentrated solution for 3 times, The extracts were combined, concentrated to 1 / 20 of the original volume, and 2 times the volume of silica gel was added to mix the sample to obtain a mixed sample. The mixed sample and 120 mesh silica gel were packed in a column at a mass ratio of 1:10, and the mixture was mixed with chloroform and ethyl acetate. Mix at a volume ratio of 20:1 to elute and remove impurities, and then mix at a volume ratio of 10:1 to elute the active ingre...

Embodiment 2

[0067]Take 100kg of mangosteen peel, wash and crush it, add 4 times the volume of 75% ethanol, extract twice at 80°C for 2 hours each time, collect the first, second and third extraction liquids respectively, and pass each extraction liquid through centrifugation Machine centrifugation, filtration, combined, at a temperature of 60°C and a pressure of 0.06MPa, concentrated under reduced pressure until no alcohol smell, to obtain a concentrated solution, adding 5 times the volume of ethyl acetate to extract the concentrated solution 3 times, combined The extract is concentrated to 1 / 20 of the original volume of the specific gravity, and 2 times the volume of silica gel is added to obtain a mixed sample. The mixed sample and 120 mesh silica gel are packed in a column at a mass ratio of 1:10, and the volume ratio of chloroform and acetone is 40:1. 1. After mixing, elute and remove impurities, and then mix according to the volume ratio of 20:1 to elute the active ingredient, and use...

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Abstract

The invention relates to a method for extracting alpha-mangostin from a mangosteen fruit peel. The method comprises the following realization steps: (I) extracting the mangosteen fruit peel; (II) concentrating an extracting solution; mixing the extracting solution of every time and concentrating under reduced pressure to obtain a concentrated solution; (III) leaching the solution; (IV) carrying out silica gel column chromatography; (V) carrying out coarse crystallization; and (VI) carrying out recrystallization: adding a primary crystal into an organic solvent with the volume of 1 to 5 times to carry out thermal dissolution; placing the solution after finishing the thermal dissolution, reducing the temperature to a room temperature, carrying out recrystallization, and controlling the crystallization time to between 10 and 20 hours; and filtering and centrifugating a recrystallization liquid, drying the liquid in vacuum to obtain the 98 percent alpha-mangostin. The method has the advantages of simple process and short operation time.

Description

technical field [0001] The invention relates to a method for extracting polyphenol compounds from plants, in particular to a method for extracting α-mangostin from mangosteen peel. Background technique [0002] Mangosteen (Garcinia mangostana L.), also known as mangosteen, mangosteen, and phoenix fruit, is the fruit of the evergreen tree mangosteen of the genus Garcinia in the family Guttiferae. Because mangosteen peel contains α-mangostin, it is often used to treat abdominal pain, diarrhea, dysentery, infectious wounds, suppuration, chronic ulcers, leucorrhea, gonorrhea and other diseases. In recent years, α-mangostin in mangosteen peel has become a research hotspot. The extraction methods of α-mangostin include water extraction, alcohol extraction, and macroporous adsorption resin separation method. [0003] Chinese patent 200610016501.4 published on September 20, 2006 discloses a "mangosteen peel extract and its extraction method and medicinal use". In this method, the m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/86A61K36/185
Inventor 王晓莹肖红秦小武高娟王春德
Owner SHAANXI JIAHE PHYTOCHEM
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