Improved method for preparing aceclofenac

Abstract

The invention provides an improved method used for preparing aceclofenac. The improved method is characterized in that (1) the method takes diclofenac sodium and tert-butyl chloroacetate as raw materials and iodide as a catalyst, and heats the substances to carry out condensation reaction; (2) the method takes tert-butyl aceclofenac as a raw material to carry out acidolysis reaction under the action of phenol and acid, and obtains aceclofenac crystal after post treatment and fine purification; and the total yield of both steps is above 88 percent and the content is over 99.2 percent (detected by HPLC). The improved method increases the yield and the content, and has short reaction time, simple and convenient operation and mild reaction conditions; and a reaction reagent is easy to recycle, so the improved method reaches the effects of lowering cost and reducing environment pollution.

Description

technical field

[0001] The invention relates to a preparation method of a non-steroidal anti-inflammatory analgesic drug, in particular to a preparation method of aceclofenac. Background technique

[0002] The chemical name of Aceclofenac is 2-(2,6-dichloroanilino)phenylacetoxyacetic acid, and its chemical structure is as follows:

[0003]

[0004] Developed by the Spanish Almirallprodesfarma pharmaceutical company, it was first listed in Spain in 1992, and it was included in the European Pharmacopoeia and the British Pharmacopoeia in 1998. This product is a powerful oral non-steroidal anti-inflammatory drug, suitable for the treatment of various rheumatoid arthritis and rheumatoid arthritis It is also suitable for pain and fever caused by various diseases. It is a safe and reliable drug for treating acute and chronic pain and anti-inflammation. It has strong anti-inflammatory and analgesic properties and few conventional anti-inflammatory and analgesic drugs Gastrointes...

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