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Caffeic acid composition and preparation method thereof

The technology of a composition and caffeic acid is applied in the directions of drug combinations, pharmaceutical formulations, medical preparations of inactive ingredients, etc., which can solve the problems of low bioavailability, unstable products, and large adverse reactions, and achieve rapid drug release, Complete disintegration and complete absorption effect

Active Publication Date: 2009-10-14
DEZHOU DEYAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The main features of the composition are: complete disintegration, rapid drug release, reduced damage to the drug by gastric juice, complete drug absorption, and quickly reach blood drug concentration, significantly improving the bioavailability of the present invention, fundamentally It solves the problems of low bioavailability, unstable products, and large adverse reactions of caffeic acid preparations currently on the market

Method used

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  • Caffeic acid composition and preparation method thereof
  • Caffeic acid composition and preparation method thereof
  • Caffeic acid composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0117] Prepare 1000 caffeic acid tablets whose specification is 0.1 parts by weight / tablet, and the prescription is as follows:

[0118] (1) A particles

[0119] 100 parts by weight of caffeic acid

[0120] PEG6000 50 parts by weight

[0121] Hypromellose 200 parts by weight

[0122] Xylitol ester 10 parts by weight

[0123] 55% ethanol 40 parts by weight

[0124] (2) B particles

[0125] 100 parts by weight of sodium carboxymethyl starch

[0126] Starch 300 parts by weight

[0127] Xylitol ester 5 parts by weight

[0128] 55% ethanol 100 parts by weight

[0129] (3) plus

[0130] 5 parts by weight of magnesium stearate

[0131] Croscarmellose sodium 8 parts by weight

[0132] The preparation method of above-mentioned tablet is as follows:

[0133] 【Operation process】

[0134] 1. Melt the specified amount of caffeic acid and PEG6000A at about 135°C, then fully mix with the specified amount of hydroxypropylmethylcellulose and sodium carboxymethyl starch, then add xyl...

Embodiment 2

[0138] Prepare 1000 caffeic acid tablets whose specification is 0.1 parts by weight / tablet, and the prescription is as follows:

[0139] (1) A particles

[0140] 100 parts by weight of caffeic acid

[0141] PEG6000 150 parts by weight

[0142] Hypromellose 250 parts by weight

[0143] Xylitol ester 15 parts by weight

[0144] 55% ethanol 150 parts by weight

[0145] Appropriate amount

[0146] (2) B particles

[0147] 200 parts by weight of sodium carboxymethyl starch

[0148] Starch 300 parts by weight

[0149] Xylitol ester 7 parts by weight

[0150] 55% ethanol 175 parts by weight

[0151] (3) plus

[0152] 5 parts by weight of magnesium stearate

[0153] 12 parts by weight of croscarmellose sodium

[0154] The preparation method of above-mentioned tablet is as follows:

[0155] 【Operation process】

[0156] 1. Melt the specified amount of caffeic acid and PEG6000A at about 145°C, then fully mix with the specified amount of hydroxypropylmethylcellulose and sodi...

Embodiment 3

[0160] Prepare 1000 caffeic acid tablets whose specification is 0.1 parts by weight / tablet, and the prescription is as follows:

[0161] (1) A particles

[0162] 100 parts by weight of caffeic acid

[0163] PEG6000 45 parts by weight

[0164] Hypromellose 205 parts by weight

[0165] Xylitol ester 11 parts by weight

[0166] 55% ethanol 120 parts by weight

[0167] (2) B particles

[0168] 98 parts by weight of sodium carboxymethyl starch

[0169] Starch 295 parts by weight

[0170] Xylitol ester 4 parts by weight

[0171] 55% ethanol 120 parts by weight

[0172] (3) plus

[0173] 6 parts by weight of magnesium stearate

[0174] Croscarmellose sodium 9 parts by weight

[0175] The preparation method of above-mentioned tablet is as follows:

[0176] 【Operation process】

[0177] 1. Melt the specified amount of caffeic acid and PEG6000A at about 135°C, then fully mix with the specified amount of hydroxypropylmethylcellulose and sodium carboxymethyl starch, then add x...

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Abstract

The invention relates to a caffeic acid composition which is characterized by comprising an A composition, a B composition, surface active agent, quick-effect disintegrant and lubricant; the A composition is caffeic acid and a medicinal accessory, and the B composition is a medicinal accessory; the weight ratio of the A composition and the B composition ranges from 1: 5.5 to 1: 1; and the caffeic acid accounts for 15 percent (W W) of the A composition at 10 DEG C. The standard of the caffeic acid composition is 0.95-0.105 weight part, wherein 0.1 weight part is the best. The caffeic acid composition and the preparation method thereof solves the problems concerning fast medicine disintegration and fast medicine effect and in particular greatly improves the bioavailability and the tablet stability of a caffeic acid tablet in the body.

Description

technical field [0001] The invention relates to a caffeic acid composition and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Bleeding disorder is a disease that threatens the patient's life. At present, commonly used hemostatic drugs in clinical practice, such as vitamin K and 6-aminocaproic acid, have slow hemostatic effects and have adverse reactions in varying degrees. Therefore, there is an urgent need to develop new hemostatic drugs with higher curative effect, faster action and lower side effects. [0003] Caffeic acid is a component of chlorogenic acid contained in various Chinese herbal medicines such as ramie, capillary, artichoke, etc., English name: Caffeic acid, chemical name: 3-(3,4-dihydroxyphenyl)-acrylic acid, molecular formula: C 9 h 8 o 4 , Molecular weight: 180.16, the chemical structural formula is shown in the figure below: [0004] [0005] Due to the low extraction ...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61K47/38A61K47/14A61P7/04
Inventor 卞建钢潘秀芝赵金水
Owner DEZHOU DEYAO PHARMA
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