Plastic umbilical plaster for external use, preparation method thereof, plastic infantile diarrhea umbilical plaster and preparation method thereof

Abstract

The invention relates to a plastic umbilical plaster for external use, a preparation method thereof, a plastic infantile diarrhea umbilical plaster and a preparation method thereof. The plastic umbilical plaster comprises the following matrix raw materials in portion by mass: 30 to 80 portions of polyvinylpyrrolidone, 50 to 100 portions of alginate, 200 to 500 portions of zinc oxide, 300 to 750 portions of glycerol, and 800 to 1,000 portions of distilled water. The preparation method for the plastic umbilical plaster comprises the following steps: adding the polyvinylpyrrolidone and the glycerol into water, and stirring the mixture until the polyvinylpyrrolidone and the glycerol are dissolved; cooling the mixture, adding the alginate, stirring the mixture until the mixture is gelatinous, adding the zinc oxide, and stirring the mixture into a matrix; adding a water-soluble extract of a drug-effect raw material, an alcohol-soluble extract or volatile oil of the drug-effect raw material, and a transdermal enhancer into the matrix, and stirring the mixture into a plaster; and placing the plaster into a die for curing, and sealing and packaging the plaster to obtain the plastic umbilical plaster. The medicament comprises the following components in portion by weight: 600 to 900 portions of psoraleae, 150 to 450 portions of fructus evodiae, 300 to 600 portions of alpinia katsumadai, 100 to 450 portions of cassia, and 100 to 300 portions of clove. The plastic umbilical plaster can be kneaded into required shapes, can be combined with an umbilical part more compactly, and better plays the drug effect.

Description

technical field [0001] The present invention relates to a plastic external Chinese medicine plaster dosage form, in particular to a plastic external Chinese medicine plaster dosage form with certain plasticity suitable for the special morphological structure of the umbilicus, a preparation method of the plastic external umbilical plaster, and The plastic umbilical plaster for infantile diarrhea constituted by the dosage form, and the invention also relates to a preparation method of the plastic umbilical plaster for infantile diarrhea. Background technique [0002] Navel application therapy is a kind of external treatment in traditional Chinese medicine, and has a history of thousands of years. The dosage form of umbilical administration has been gradually improved from powder and paste to black plaster, ointment, rubber plaster, poultice, patch and so on. The dosage forms of the medicines for external use recorded in the 2005 "Chinese Pharmacopoeia" include pastes, ointmen...

AI Technical Summary

Problems solved by technology

These dosage forms have their own characteristics and relative shortcomings: ①Paste: Paste is an ancient dosage form, and the preparation process is simple and easy, but it has poor adhesion, powder is easy to scatter, and the large amount of bacteria easily leads to skin pollution, etc. Insufficient; 2. Ointment: This dosage form has low production cost and simple preparation process, but its stability is poor, and the external application of the umbilicus is easy to contaminate clothes; 3. Black plaster: Black plaster is a traditional preparation with a history of more than one thousand years of use. Low, disadvantages: the base is refined from yellow dandelion and vegetable oil, which is sensitizing to the skin and contains lead elements harmful to the human body; ④Rubber ointment: has a long production history, and the production technology is relatively mature , the cost is low, but the drug load is small, and quite a few patients have skin allergies after sticking; The dosage is large and has no skin allergies, but due to its high water content, it is prone to melting when used. For different drug formulations, it is necessary to explore different types of cataplasm bases, and the preparation conditions are strict; ⑥Patch: especially suitable for It is suitable for the preparation of western medicine or single component of traditional Chinese medicine, which is more beautiful, but the drug loading is small, so it is not suitable for the compound preparation of traditional Chinese medicine with large drug loading

[0006] At present, there are no literature and patent reports on anti-infantile diarrhea drugs composed of psoralen, evodia, cardamom, clove, and cinnamon, and there is no plastic umbilical patch for infantile diarrhea made of plastic plaster.

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