Plastic umbilical plaster for external use, preparation method thereof, plastic infantile diarrhea umbilical plaster and preparation method thereof

An infantile diarrhea and plasticity technology, which is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, ointment delivery, etc., can solve the problem of anti-infantile diarrhea drugs without literature and patent reports, skin allergies, It is not suitable for problems such as drug loading, and achieves the effects of being conducive to transdermal absorption, good drug efficacy, and good skin permeability

Inactive Publication Date: 2009-10-28
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These dosage forms have their own characteristics and relative shortcomings: ①Paste: Paste is an ancient dosage form, and the preparation process is simple and easy, but it has poor adhesion, powder is easy to scatter, and the large amount of bacteria easily leads to skin pollution, etc. Insufficient; 2. Ointment: This dosage form has low production cost and simple preparation process, but its stability is poor, and the external application of the umbilicus is easy to contaminate clothes; 3. Black plaster: Black plaster is a traditional preparation with a history of more than one thousand years of use. Low, disadvantages: the base is refined from yellow dandelion and vegetable oil, which is sensitizing to the skin and contains lead elements harmful to the human body; ④Rubber ointment: has a long production history, and the production technology is relatively mature , the cost ...

Method used

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  • Plastic umbilical plaster for external use, preparation method thereof, plastic infantile diarrhea umbilical plaster and preparation method thereof
  • Plastic umbilical plaster for external use, preparation method thereof, plastic infantile diarrhea umbilical plaster and preparation method thereof
  • Plastic umbilical plaster for external use, preparation method thereof, plastic infantile diarrhea umbilical plaster and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] The preparation method of plastic Chinese medicine umbilical plaster is characterized in that it is made up of following steps:

[0073] Step 1. Proportion the following raw materials as follows: 50 parts of polyvinylpyrrolidone, 80 parts of sodium alginate, 400 parts of zinc oxide, 630 parts of glycerin, and 1000 parts of distilled water;

[0074] Step 2. Add the above ratio of polyvinylpyrrolidone and glycerin into distilled water, stir in a water bath at 80°C until dissolved, add sodium alginate when the solution is cooled to 60°C, and stir until all the sodium alginate dissolves into a gel. Add zinc oxide, stir, and mix evenly to form a blank matrix;

[0075] Step 3. Add water-soluble extracts of medicinal raw materials, alcohol-soluble medicinal raw materials or volatile oily and transdermal accelerators to the blank matrix in proportion, stir, and mix evenly;

[0076] Step 4. The ointment obtained in step 3 was placed in a mold, cured in an oven at 40° C. for 4 h...

Embodiment 2

[0078] The preparation method of plastic Chinese medicine umbilical plaster is characterized in that it is made up of following steps:

[0079] Step 1. Proportion the following raw materials as follows: 30 parts of polyvinylpyrrolidone, 80 parts of alginate, 400 parts of zinc oxide, 630 parts of glycerin, and 1000 parts of distilled water;

[0080] Step 2. Add the above ratio of polyvinylpyrrolidone and glycerin into distilled water, stir in a water bath at 80°C until dissolved, add alginate when the solution is cooled to 60°C, and stir until the alginate is completely dissolved into a gel. Add zinc oxide, stir, and mix evenly to form a blank matrix;

[0081] Step 3. Add the water-soluble extract, the alcohol-soluble extract or the volatile oily and transdermal enhancer of the medicinal raw material into the blank matrix in proportion, and stir and mix to make the color uniform;

[0082] Step 4. The ointment obtained in step 3 was placed in a mold, cured in an oven at 40° C. ...

Embodiment 3

[0084] The preparation method of plastic Chinese medicine umbilical plaster is characterized in that it is made up of following steps:

[0085] Step 1. Proportion the following raw materials as follows: 80 parts of polyvinylpyrrolidone, 50 parts of alginate, 500 parts of zinc oxide, 750 parts of glycerin, and 1000 parts of distilled water;

[0086] Step 2. Add the above ratio of polyvinylpyrrolidone and glycerin into distilled water, stir in a water bath at 80°C until dissolved, add alginate when the solution is cooled to 60°C, and stir until the alginate is completely dissolved into a gel. Add zinc oxide, stir, and mix evenly to form a blank matrix;

[0087] Step 3. Add water-soluble extracts of medicinal raw materials, alcohol-soluble medicinal raw materials or volatile oily and transdermal accelerators to the blank matrix in proportion, stir, and mix evenly;

[0088] Step 4. The ointment obtained in step 3 was placed in a mold, cured in an oven at 40° C. for 3.5 hours, and...

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Abstract

The invention relates to a plastic umbilical plaster for external use, a preparation method thereof, a plastic infantile diarrhea umbilical plaster and a preparation method thereof. The plastic umbilical plaster comprises the following matrix raw materials in portion by mass: 30 to 80 portions of polyvinylpyrrolidone, 50 to 100 portions of alginate, 200 to 500 portions of zinc oxide, 300 to 750 portions of glycerol, and 800 to 1,000 portions of distilled water. The preparation method for the plastic umbilical plaster comprises the following steps: adding the polyvinylpyrrolidone and the glycerol into water, and stirring the mixture until the polyvinylpyrrolidone and the glycerol are dissolved; cooling the mixture, adding the alginate, stirring the mixture until the mixture is gelatinous, adding the zinc oxide, and stirring the mixture into a matrix; adding a water-soluble extract of a drug-effect raw material, an alcohol-soluble extract or volatile oil of the drug-effect raw material, and a transdermal enhancer into the matrix, and stirring the mixture into a plaster; and placing the plaster into a die for curing, and sealing and packaging the plaster to obtain the plastic umbilical plaster. The medicament comprises the following components in portion by weight: 600 to 900 portions of psoraleae, 150 to 450 portions of fructus evodiae, 300 to 600 portions of alpinia katsumadai, 100 to 450 portions of cassia, and 100 to 300 portions of clove. The plastic umbilical plaster can be kneaded into required shapes, can be combined with an umbilical part more compactly, and better plays the drug effect.

Description

technical field [0001] The present invention relates to a plastic external Chinese medicine plaster dosage form, in particular to a plastic external Chinese medicine plaster dosage form with certain plasticity suitable for the special morphological structure of the umbilicus, a preparation method of the plastic external umbilical plaster, and The plastic umbilical plaster for infantile diarrhea constituted by the dosage form, and the invention also relates to a preparation method of the plastic umbilical plaster for infantile diarrhea. Background technique [0002] Navel application therapy is a kind of external treatment in traditional Chinese medicine, and has a history of thousands of years. The dosage form of umbilical administration has been gradually improved from powder and paste to black plaster, ointment, rubber plaster, poultice, patch and so on. The dosage forms of the medicines for external use recorded in the 2005 "Chinese Pharmacopoeia" include pastes, ointmen...

Claims

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Application Information

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IPC IPC(8): A61K36/9064A61K9/06A61K47/36A61P1/12
Inventor 贾晓斌陈彦高成林
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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