Chinese medicinal composition for treating primary dysmenorrheal and preparation method thereof

Abstract

The invention discloses a medicinal composition for treating primary dysmenorrheal and a preparation method thereof. The medicinal composition comprises the following components according to the weight proportion: 50 to 150 portions of angelic, 30 to 90 portions of cinnamon, 30 to 90 portions of radix aucklandiae, and 75 to 225 portions of rhizoma corydalis processed with vinegar. Volatile oil is extracted from the angelica, the mixture of a water extraction of the extracted angelica is deposited in alcohol to obtain an angelica polysaccharide, and an angelica phenolic acid is obtained by an ethanol supernate which is loaded onto a macroporous absorption resin column and is eluted by ethanol; the volatile oil is extracted from the cinnamon and the radix aucklandiae, and clear paste is prepared from the ethanol supernate of a water decoction of herb residue extracted with the volatile oil which is reclaimed with the ethanol and is concentrated; a rhizoma corydalis alkaloid is extracted from the rhizoma corydalis by performing ethanol reflux extraction, loading the rhizoma corydalis alkaloid onto the macroporous absorption resin column and eluting by the ethanol; and the extracts are mixed to obtain an active component of the pharmaceutical composition. The medicinal composition maintains the analgesic effect of the prior art, reduces adverse reaction of dysmenorrhea, and has better spasmolysis at the same time. The preparation method has reasonable process and can be applied to mass production.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating primary dysmenorrhea and a preparation method thereof. Background technique [0002] Dysmenorrhea refers to obvious lower abdominal pain during menstruation or before and after menstruation, manifested as distending pain or spasmodic pain, or accompanied by backache and distending pain, general discomfort, which affects life, work or study. Dysmenorrhea is divided into primary dysmenorrhea and secondary dysmenorrhea according to the incidence of dysmenorrhea. Primary dysmenorrhea refers to dysmenorrhea caused by no obvious organic lesions in the reproductive organs, mostly functional dysmenorrhea, and mainly occurs in adolescent girls and unmarried or childless young women. [0003] Western medicine mostly uses antispasmodic, sedative and analgesic therapy, oral contraceptives, prostate synthase inhibi...

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Problems solved by technology

[0006] Since the original prescription of Tongjingbao Granules is composed of nine traditional Chinese medicines, there are many types of medicines used, and the dosage of the preparations is relatively large. It is relatively difficult to control the quality during the production process. In clinical use, due to its strong effect of promoting blood circulation and removing blood stasis, After taking it, patients often have adverse reactions that reflect a significant increase in menstrual flow

[0007] After searching, there are some traditional Chinese medicine compositions for treating primary dysmenorrhea in the existing patents such as "Tongjingsan Granule" (patent No. 93111705.4), "a kind of oral Chinese medicine for treating primary dysmenorrhea" (application No. 200610130819.5), "a A traditional Chinese medicine composition for the treatment of dysmenorrhea" (application number 200810139921.0), etc., but there are many types of medicines that make up these prescriptions, and they are mostly taken as decoctions, or the process is relatively simple. After extracting the extract, they are directly made into oral preparations, although It has a certain effect, but the extraction rate of active ingredients is not high, and the preparation is relatively thick, which is not conducive to controlling its production quality

[0008] Although some compositions have a simple medi

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