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Hyperbranched polyphosphate with biocompatibility and method for synthesizing the same

A technology of biocompatibility and polyphosphate, which is applied in the field of polymer materials, achieves the effects of high rheology, high product purity and simple preparation method

Inactive Publication Date: 2011-11-16
SHANGHAI JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Likewise, the ring-opening polymerization of cyclic phosphate esters without catalysts has not been reported yet.

Method used

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  • Hyperbranched polyphosphate with biocompatibility and method for synthesizing the same
  • Hyperbranched polyphosphate with biocompatibility and method for synthesizing the same
  • Hyperbranched polyphosphate with biocompatibility and method for synthesizing the same

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The first step, put 3.0g (17.8mmol) 2-hydroxyethoxy-2-oxo-1,3,2-dioxaphospholane in the reaction bottle and then magnetically stir the reaction in an oil bath at 60°C 60 hours;

[0024] In the second step, add 10 milliliters of ethanol to the reaction bottle, and precipitate in acetone after being completely dissolved, wash repeatedly with acetone and then vacuum-dry to obtain light yellow viscous liquid hyperbranched polyphosphate with a yield of 90.6% .

[0025] Such as figure 1 Shown, is the polymer structure schematic diagram that the present embodiment makes, and the chemical formula of gained hyperbranched polyphosphate is:

[0026]

[0027] Where: R=CH 2 CH 2 -.

[0028] The molecular weight is determined by gel permeation chromatography (GPC), using water (containing 0.01mol / L sodium nitrate) as the eluent, the measured molecular weight is 2900, and the molecular weight distribution index is 4.10.

[0029] Such as figure 2 with image 3 Shown, is the...

Embodiment 2

[0031] The first step, put 3.0g (14.2mmol) 4-hydroxybutoxy-2-oxo-1,3,2-dioxaphospholane in the reaction bottle and then magnetically stir the reaction in an oil bath at 60°C 60 hours;

[0032] In the second step, 10 milliliters of ethanol was added to the reaction flask, and after being completely dissolved, it was precipitated in acetone, washed repeatedly with acetone, and then vacuum-dried to obtain a yellow viscous liquid hyperbranched polyphosphate with a yield of 88.0%.

[0033] Such as Figure 5 As shown, it is a schematic diagram of the polymer structure obtained in the present embodiment, and the chemical formula of the gained hyperbranched polyphosphate is:

[0034]

[0035] Where: R=-CH 2 CH 2 CH 2 CH 2 -.

[0036] The molecular weight is determined by gel permeation chromatography (GPC), using water (containing 0.01mol / L sodium nitrate) as the eluent, the measured molecular weight is 2200, and the molecular weight distribution index is 2.50.

Embodiment 3

[0038] The first step, 3.0g (15.3mmol) 2-(2-hydroxyethoxy) ethoxy-2-oxo-1,3,2-dioxaphospholane was placed in the reaction bottle at 60°C Magnetic stirring reaction in the oil bath of 60 hours;

[0039] In the second step, 10 milliliters of ethanol was added to the reaction bottle, and after being completely dissolved, it was precipitated in acetone, washed repeatedly with acetone, and then vacuum-dried to obtain a yellow viscous liquid hyperbranched polyphosphate with a yield of 92.5%.

[0040] As shown in Figure 6, it is the structural representation of the polymer obtained in the present embodiment, and the chemical formula of the gained hyperbranched polyphosphate is:

[0041]

[0042] Where: R=-CH 2 CH 2 OCH 2 CH 2 -.

[0043] The molecular weight is determined by gel permeation chromatography (GPC), using water (containing 0.01mol / L sodium nitrate) as the eluent, the measured molecular weight is 5000, and the molecular weight distribution index is 3.48.

[0044] Th...

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Abstract

The invention, which belongs to the field of polymer material technique, provides a hyperbranched polyphosphate with biocompatibility and a preparation method thereof, including: placing AB type annular phosphate monomer at 20-60 DEG C. for bulk polymerization reaction and then dissolving in water, methanol, ethanol, N, N-dimethylformamide or dimethyl sulphoxide; executing washing sediment and vacuum drying processes in sequence for the solution with acetone, obtaining hyperbranched polyphosphate using repeated phosphate structure as framework and hydroxyl as terminal, with biocompatibility and biodegradability. Compared with the line-shaped polyphosphate, the hyperbranched polyphosphate prepared by the invention has the advantages of low viscosity, high rheology behavior, considerable terminal functional group, as well as simple preparation method, high product purity, large scale preparation without catalyst, and plentiful terminal hydroxyls with can be further modified. Therefore, the hyperbranched polyphosphate has utility values in the fields of controlled release medicament, gene transfection, tissue engineering, etc.

Description

technical field [0001] The invention relates to a material in the technical field of polymer materials and a preparation method thereof, in particular to a biocompatible hyperbranched polyphosphate and a synthesis method thereof. Background technique [0002] Polyphosphate is a new class of biomaterials and has attracted widespread attention. Because its structure is similar to natural phosphorus-containing polymers such as nucleic acid and teichoic acid in organisms, it has good biocompatibility and biodegradability, strong cell drinking ability and cell membrane permeability, and its structural variability Large, has been applied in the field of biomedicine, especially genetic engineering and nerve conduit repair and so on. Leong's group has done a lot of useful exploratory work in this field. The study found that the introduction of polyphosphate in the polymer can effectively improve the physical and mechanical properties of the material, improve the hydrophilicity and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G79/04
Inventor 刘尽尧黄卫颜德岳
Owner SHANGHAI JIAOTONG UNIV
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