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Chewing soft capsule shell, chewing soft capsule drug and prepration method thereof

A soft capsule skin and soft capsule technology, which is applied in capsule delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve problems such as high toughness, high chewing hardness, and high mechanical strength

Active Publication Date: 2010-01-20
BEIJING HANGYANG CAPSULE TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] For this reason, the technical problem to be solved by the present invention is that the mechanical strength of the hard capsule or chewable soft capsule skin in the prior art is large, and the toughness is high, and the chewing hardness is large and the chewing feeling is not good when the user chews this type of soft capsule, thereby Provide a chewable soft capsule with low mechanical strength and toughness

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A method for preparing a soft chewing capsule medicine, which comprises the following steps:

[0029] (1) Weigh 31g gelatin, 20g glycerin, 43g purified water, 0.2g sodium alginate, 0.36g carrageenan, 0.44g pectin, 2g sorbitol, 3g polyvinyl alcohol 400, and add purified water and seaweed to the gel tank Sodium, carrageenan and pectin are mixed thoroughly, then sorbitol and polyvinyl alcohol 400 are added to the glue tank, and finally gelatin is added, and the above raw materials are fully mixed in the glue tank for use;

[0030] (2) The mixed solution mixed in step (1) is subjected to gumming at a temperature of 68° C. for 1.5 hours to obtain a gum solution;

[0031] (3) Stabilize the glue from the glue tank in step (2) for 2 hours, and then flow into the glue box through the hose. The glue flows out from the gap under the glue box and flows onto the rubber wheel directly below the glue box. Form rubber with uniform thickness;

[0032] (4) The contents are compressed into the s...

Embodiment 2

[0036] A method for preparing a soft chewing capsule medicine, which comprises the following steps:

[0037] (1) Weigh 25g gelatin, 15g glycerin, 49.5g purified water, 1g sodium alginate, 1g carrageenan, 1g pectin, 2.5g sorbitol, 5g polyvinyl alcohol 400, and add purified water and alginic acid to the gel tank Sodium, carrageenan and pectin are mixed thoroughly, then sorbitol and polyvinyl alcohol 400 are added to the glue tank, and finally gelatin is added, and the above raw materials are fully mixed in the glue tank for use;

[0038] (2) The mixed solution mixed in step (1) is subjected to gumming at a temperature of 55° C. for 5 hours to obtain a gum solution;

[0039] (3) Stabilize the glue in the glue tank through step (2) to stabilize the glue for 3 hours, and then flow into the glue box through the hose. The glue will flow out from the gap under the glue box and flow onto the rubber wheel directly below the glue box. Form rubber with uniform thickness;

[0040] (4) The content...

Embodiment 3

[0044] A method for preparing a soft chewing capsule medicine, which comprises the following steps:

[0045] (1) Weigh 35g gelatin, 25g glycerin, 36.2g purified water, 0.1g sodium alginate, 0.1g carrageenan, 0.1g pectin, 1.5g sorbitol, 2g polyvinyl alcohol 400, and add purified water to the gel tank , Sodium alginate, carrageenan and pectin and mix them thoroughly, then add sorbitol and polyvinyl alcohol 400 to the glue tank, and finally add gelatin. Mix the above raw materials in the glue tank for later use;

[0046] (2) The mixed solution mixed in step (1) is subjected to gelatinization at a temperature of 75°C for 1 hour to obtain a gel solution;

[0047] (3) Stabilize the glue from the glue tank in step (2) for 1 hour, and then flow into the glue box through the hose. The glue flows out from the gap under the glue box and flows onto the rubber wheel directly below the glue box. Form rubber with uniform thickness;

[0048] (4) The contents are compressed into the skin of the soft ...

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PUM

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Abstract

The invention relates to a chewing soft capsule shell, a chewing soft capsule drug and a prepration method thereof. The soft capsule shell consists of the following raw materials: 25-35 wt% of gelatin, 15-25 wt% of glycerol, 35-50 wt% of purified water, 0.1-1 wt% of sodium alginate, 0.1-1 wt% of carrageenan, 0.1-1 wt% of pectin, 1.5-2.5 wt% of sorbitol and 2-5 wt% of polyvinyl alcohol 400. The chewing soft capsule shell further comprises the following components: 0.1-0.3 wt% of sweetener, 0.2-0.4 wt% of acidifier, 0.001-0.01 wt% of spice, 0.001-0.01 wt% of preservative and 0.001-0.01 wt% of pigment. The soft capsule shell prepared by the raw materials has the advantages of small mechanical strength and toughness, and the invention further provides the method for preparing the chewing soft capsule drug.

Description

Technical field [0001] The invention relates to a soft capsule, in particular to a chewing soft capsule skin and a capsule medicine thereof, belonging to the technical field of medicine. Background technique [0002] As an emerging drug delivery system, soft capsules can effectively ensure the stability of their contents due to their unique closed soft packaging characteristics, and are widely used due to their own dose controllability and portability. In recent years, for the purpose of improving the usability of pharmaceutical preparations, there has been an increasing demand for chewable soft capsules that can be easily taken even without water. Therefore, the preparation of the chewable soft capsule skin is realized by adding an appropriate amount of glycerin and sorbitol to the raw material of the soft capsule skin. However, merely improving the chewability of the chewable soft capsule skin is far from satisfying the requirements of the users. As a result, a chewable soft c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/42A61K47/36A61K47/10A61K47/32A61K9/48
Inventor 霍晋涛周洋程鹏
Owner BEIJING HANGYANG CAPSULE TECH
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