Glucosamine chewable tablet used for relieving and preventing osteoarthritis and preparation method thereof
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A technology for glucosamine and osteoarthritis, applied in the field of glucosamine medical and health care products, can solve the problems of drug refusal, difficulty in taking, and inconvenient taking, and achieve the effects of increasing the number of takings, high bioavailability, and improving drug efficacy
Active Publication Date: 2010-02-17
JIANGSU ALAND NOURISHMENT
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Problems solved by technology
However, the current glucosamine hydrochloride is generally an oral gastric-soluble swallowable preparation. The drug cannot be absorbed quickly, the onset of effect is slow, and it is inconvenient to take. Especially for the elderly and patients with dysphagia, ordinary tablets are often difficult to take. , aggravate the gastrointestinal burden and cause discomfort, and long-term medication may even lead to psychological drug resistance
In addition, because the drug needs to be slowly disintegrated and released when it reaches the gastrointestinal tract, the bioavailability of glucosamine in the human body is not high
Method used
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Embodiment 1
[0012] Embodiment 1 Glucosamine sulfate 200g
[0013] Polyvinylpyrrolidone 3g
[0014] Vitamin C 20g
[0015] Dimethylsulfone 50g
[0016] Starch 20g
[0017] White sugar 100g
[0018] Sorbitol 450g
[0019] Mannitol 220g
[0020] Aspartame 2g
[0021] Edible flavor 10g
[0022] Anhydrous citric acid 20g
[0023] Magnesium Stearate 5g
[0024] Glycosamine sulfate is crushed through a 80-100 mesh sieve, granulated with polyvinylpyrrolidone, dried, and the granules are passed through a 12-20 mesh sieve; the granules are mixed with vitamin C, dimethyl sulfone, starch, white sugar, and sorbitol , mannitol, aspartame, edible essence and anhydrous citric acid are evenly mixed, then added magnesium stearate and pressed into tablets.
[0025] Example 1 contains white granulated sugar and is a sugar-containing glucosamine chewable tablet with a good mouthfee...
Embodiment 2
[0026] Embodiment 2 Glucosamine sulfate 100g
[0027] Glucosamine Hydrochloride 100g
[0028] Polyvinylpyrrolidone 30g
[0029] Vitamin C 20g
[0030] Dimethylsulfone 50g
[0031] Starch 15g
[0032] Sorbitol 509g
[0033] Mannitol 265g
[0034] Xylitol 20g
[0035] Edible flavor 30g
[0036] Magnesium stearate 8g
[0037] Glycosamine sulfate and hydrochloride are crushed through 80-100 mesh sieves, granulated with polyvinylpyrrolidone, dried, and the granules are passed through 12-20 mesh sieves; the granules are mixed with vitamin C, dimethyl sulfone, starch, Alcohol, mannitol, xylitol, edible essence are mixed evenly, add magnesium stearate and press into tablet.
[0038] Example 2 does not contain white sugar, and is a sugar-free glucosamine chewable tablet, which is especially suitable for special groups such as diabetic patients.
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Abstract
The invention discloses a glucosamine chewable tablet used for relieving and preventing osteoarthritis and a preparation method thereof. The glucosamine chewable tablet comprises active ingredients and auxiliary materials, wherein the active ingredients comprise glucosamine, vitamin C and dimethyl sulfone, the glucosamine is glucosamine sulfate or glucosamine hydrochloride or glucosamine phosphateor mixture of the glucosamine sulfate and the glucosamine hydrochloride and the glucosamine phosphate; and the auxiliary materials comprise excipient, bonding agent, flavouring agent and lubricant. The glucosamine chewable table is slowly disintegrated and released without entering the gastrointestinal tract through the chewing and is absorbed through the increment of the taking number, therefore, the medicine effect is improved, and the discomfort of a patient with poor gastrointestinal tract function, caused by a deglutible tablet accelerating the gastrointestine load, is reduced. The glucosamine chewable tablet has the advantages of good mouth feel, high bioavailability, more convenient taking, convenient carrying and the like, and can fully play a role of the product.
Description
technical field [0001] The invention belongs to the technical field of glucosamine medicine and health care products, and in particular relates to a glucosamine chewable tablet for alleviating and preventing osteoarthritis and a preparation method thereof. Background technique [0002] Treatment methods for osteoarthritis include drug therapy, surgery, physical therapy, physical therapy and other adjuvant treatments. Among them, drug therapy is the most widely used, and non-steroidal drugs are currently the most commonly used drugs for the treatment of osteoarthritis clinically, including ibuprofen, diclofenac, meloxicam, nebumetone, etc. Although this drug is effective in reducing symptoms, it is not a drug for the cause of osteoarthritis. The mechanism of action of non-steroidal anti-inflammatory drugs is mainly to achieve anti-inflammatory and analgesic effects by inhibiting cyclooxygenase. However, the side effects of non-steroidal anti-inflammatory drugs are also obvio...
Claims
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Application Information
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