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Medicinal composition for treating glaucoma and application thereof

A composition and glaucoma technology, applied in the field of pharmacy, can solve the problems of unclear active ingredient group of collagen, infeasibility, unclear collagen process parameters, etc.

Inactive Publication Date: 2010-02-17
BEIJING HERUN INNOVATION PHARMA TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the patent application for collagen eye drops (publication number CN1927391A), the collagen used has no clear active ingredient group, and the process parameters are not clear when preparing collagen, which leads to unclear effective parts. ; Adopt pepsin or papain to carry out enzymolysis in this patent application, because pepsin enzymolysis specific limitation, it can not enzymolyze the proline peptide bond in the collagen, that is to say that pepsin can't enzymatically decompose collagen into Collagen, so the collagen described in this patent application is not collagen in the actual sense (relative molecular weight is not higher than 100kD), so this patent application is not feasible; in the patent application for composite collagen eye drops ( Publication No. CN1927392A) added chemical medicine antibiotics to be used in conjunction with collagen, but the active ingredient group of collagen was also not clear, confusing the concept of collagen and collagen
It can be seen that the prior art does not really solve the technical problems of collagen in ophthalmic medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Prescription: 7.5g of clonidine hydrochloride, 90ml of collagen extract (containing 9g of collagen)

[0059] Preparation method: Take 2700ml of water for injection, add 1.5g of ethylparaben, heat to 80°C and stir to dissolve, add clonidine hydrochloride and collagen extract, cool down to 60°C while stirring, and then add water for injection to 3000ml , stir well, pass through a microporous membrane filter (0.22 μm), and aseptically dispense, to obtain. (Note: The collagen used is donkey-hide gelatin biomimetic hydrolysis with pepsin and trypsin, and then obtained by ultrafiltration with a 5kD ultrafiltration membrane)

Embodiment 2

[0061] Prescription: Physostigmine Salicylate 5g Sodium Hyaluronate 1g Collagen Extract 50ml (Contains Collagen 5g)

[0062] Preparation method: Take 1500ml of water for injection, add chlorobutanol, put it in a boiling water bath, stir until clarified, let it cool, add physostigmine salicylate and collagen extract under stirring, mix well, filter, add injection Make up to 2000ml with water, add sodium hyaluronate, fully swell to dissolve, stir well, pass through a microporous membrane (0.22 μm), and aseptically dispense to obtain. (Note: The collagen used is obtained from pigskin after biomimetic enzymolysis with pepsin and trypsin, and then ultrafiltration with a 10kD ultrafiltration membrane)

Embodiment 3

[0064] Prescription: 20g of pilocarpine nitrate, 50ml of collagen extract (containing 5g of collagen)

[0065] Preparation method: Add phenoxyethanol to 1000ml of water for injection that has been heated to about 80°C, stir evenly, let it cool, add pilocarpine nitrate, stir until completely dissolved, add collagen extract, and add water for injection to 2000ml, over Filter through a microporous membrane (0.22 μm), heat the filtrate to 50°C, add hypromellose (50k~70kmpa·s) while it is hot, stir to room temperature, add water for injection to 2000g, stir well, and form a uniform Gel, filtered (0.80μm), aseptically dispensed, ready to use. (Note: The collagen used is obtained from pigskin and cowhide after enzymatic hydrolysis with pepsin and papain, and then ultrafiltration with a 100kD ultrafiltration membrane)

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PUM

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Abstract

The invention discloses a medicinal composition for treating glaucoma, which consists of collagen and medicaments for miosis and blood pressure reduction, and belongs to the field of pharmacy. Raw material medicaments of effective components of the medicinal composition comprise collagen and medicaments for miosis and blood pressure reduction such as clonidine hydrochloride, physostigmine salicylate, pilocarpine nitrate and the like which are prepared into various eye preparations by combining the prior art. The technical scheme creatively combines and applies the collagen and the effective components of the medicaments in the eye preparations so as to enlarge the application range of the collagen and achieve better effect in the aspect of treating various glaucomas.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating glaucoma, which is composed of collagen, miotic and antihypertensive drugs, and belongs to the field of pharmacy. Background technique [0002] Glaucoma is a common disease in ophthalmology, which greatly endangers vision function and is also one of the most common blinding eye diseases. Due to various reasons, it will bring blindness to patients. Glaucoma is commonly seen with increased intraocular pressure accompanied by hyperemia around the cornea, dilated pupils, sharp vision loss, headache, nausea and vomiting and other symptoms. When the intraocular pressure of glaucoma exceeds the limit that the intraocular tissues, especially the retina, can bear, it will cause eye functional lesions and bring great pain to the majority of patients. Western medicine has remarkable effects in treating these diseases. [0003] Collagen is a peptide-containing substance produced by hydrolysis or ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61K31/4178A61K31/4168A61K31/407A61K31/60A61K31/5575A61K31/5377A61K31/4704A61K31/498A61K47/42A61P27/02
Inventor 朴美善王广录
Owner BEIJING HERUN INNOVATION PHARMA TECH DEV
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