Check patentability & draft patents in minutes with Patsnap Eureka AI!

Coenzyme Q nanostructured lipid carrier and preparation method thereof

A nanostructured lipid and coenzyme technology, applied in the field of carrier systems, can solve the problems of poor drug stability and low bioavailability of coenzyme Q, and achieve the effects of convenient preparation, simple preparation method, and easy fusion

Active Publication Date: 2013-03-06
苏州纳康生物科技有限公司
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a water-soluble coenzyme Q nanostructure lipid carrier with high stability and good compatibility, which solves the problems of poor stability and low bioavailability of coenzyme Q drugs in the prior art

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Coenzyme Q nanostructured lipid carrier and preparation method thereof
  • Coenzyme Q nanostructured lipid carrier and preparation method thereof
  • Coenzyme Q nanostructured lipid carrier and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 Preparation of Coenzyme Q Nanostructured Lipid Carrier

[0035] Composition formula

[0036]

[0037] Preparation steps:

[0038] 1. Weigh 0.5 g of O / 100G, 4.5 g of Tween 80, 3.5 g of GMS, and 1.5 g of glyceryl caprylate into a beaker, and heat in a water bath at 65°C.

[0039] 2. After the substance in the beaker is completely melted, add 1.0 g of CoQ 10 , heated and stirred evenly;

[0040] 3. Add 89 grams of distilled water at 65°C to the above system and stir evenly. At the same time, turn on the high-pressure homogenizer and preheat it with distilled water at 65°C;

[0041] 4. Put the uniformly stirred high-temperature emulsion system into a high-pressure homogenizer, adjust the homogenization pressure to 60MPa, and circulate 9 times under this pressure;

[0042] 5. Bring to room temperature to obtain a clear and transparent aqueous dispersion of CoQ10-NLC. The particle size of the dispersion measured by photon correlation spectroscopy (PCS) is 46....

Embodiment 2

[0043] Example 2 Preparation of Coenzyme Q Nanostructured Lipid Carrier

[0044] Composition formula

[0045]

[0046] Preparation steps:

[0047] 1. Weigh 0.5 grams of soybean lecithin, 4.5 grams of Tween 80, 3.5 grams of GMS, and 1.5 grams of glyceryl caprylate into a beaker, and heat in a water bath at 65°C.

[0048] 2. After the substance in the beaker is completely melted, add 2.0 grams of CoQ10, heat and stir evenly;

[0049] 3. Add 88 grams of distilled water at 65°C to the above system and stir evenly. At the same time, turn on the high-pressure homogenizer and preheat it with distilled water at 65°C;

[0050] 4. Put the uniformly stirred high-temperature emulsion system into a high-pressure homogenizer, adjust the homogenization pressure to 60MPa, and circulate 9 times under this pressure;

[0051] 5. Bring to room temperature to obtain a clear and transparent aqueous dispersion of CoQ10-NLC. The particle size of the dispersion measured by photon correlation spect...

Embodiment 3

[0052] Example 3 Preparation of Coenzyme Q Nanostructured Lipid Carrier

[0053] Composition formula

[0054]

[0055] Preparation steps:

[0056] 1. Weigh 0.5 g of hexaglyceryl monostearate, 4.5 g of Tween 80, 4.9 g of GMS, and 2.1 g of glyceryl caprylate into a beaker, and heat in a water bath at 65°C.

[0057] 2. After the substance in the beaker is completely melted, add 3.0 grams of CoQ10, heat and stir evenly;

[0058] 3. Add 85.0 grams of distilled water at 65°C to the above system and stir evenly. At the same time, turn on the high-pressure homogenizer and preheat it with distilled water at 65°C;

[0059] 4. Put the uniformly stirred high-temperature emulsion system into a high-pressure homogenizer, adjust the homogenization pressure to 60MPa, and circulate 9 times under this pressure;

[0060] 5. The aqueous dispersion of CoQ10-NLC obtained at room temperature is semi-clear and transparent, and the particle diameter of the dispersion measured by photon correlati...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a coenzyme Q nanostructured lipid carrier and a preparation method thereof. The composition is as follows according to mass percentage: 1-5 percent of coenzyme Q, 0.5-25 percent of emulsifier, 0. 5-25 percent of lipid materials and the balance of water or water solution containing water-soluble surfactant. The composition has good stability and water solubility, simple andcontrollable preparation method, and good repeatability, and can be applied to the preparation of cosmetics and health food with the coenzyme Q.

Description

technical field [0001] The invention belongs to the technical field of carrier systems in cosmetics and food preparation technology, and relates to a nanoscale carrier and a preparation method thereof, in particular to a nanostructured lipid carrier with coenzyme Q10 as an active ingredient and a preparation method thereof. Background technique [0002] Coenzyme Q is a fat-soluble quinone compound that exists widely in organisms. Coenzyme Q from different sources has different numbers of isopentenyl units in its side chain. Humans and mammals have 10 isopentenyl units, so it is called coenzyme Q. 10 . coenzyme Q 10 (CoQ 10 ) alias decene quinone, ubiquinone, chemical name 2,3-dimethyl-5-methyl-6-decyl quinone, is a fat-soluble quinone compound. The substance widely exists in animal, plant and microbial cells. [0003] CoQ 10 It is an activator of cellular respiration and cellular metabolism, and also an important antioxidant and non-specific immune enhancer. CoQ 10 It...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/35A61K8/37A61K8/85A61K8/92A61K8/84A61Q19/08A23L1/29A23L33/00
Inventor 夏强王虹霞
Owner 苏州纳康生物科技有限公司
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com