Application of high-purity EPA-E and DHA polyenoic acid ethyl ester in preparation of nutritional supplement for patients in operative period

Abstract

The invention relates to application of high-purity EPA-E and DHA polyenoic acid ethyl ester in preparation of nutritional supplement for patients in operative period, wherein the high-purity EPA-E and DHA polyenoic acid ethyl ester contains eicosapentaenoic acid ethyl ester and docosahexenoic acid ethyl ester with the weight percent of more than 80 percent; and the weight ratio of the EPA-E and EHA-E is 1:1.01-1:3.8. In the invention, because the total content of the EPA-E and the DHA-E is more than 80 percent, fatty acids impurities and non-fatty impurities in fish oil are greatly removed, and adverse reaction is reduced; preparation formulation is proper, the EPA-E and the DHA-E are prevented from being oxidized, the preparation formulation is taken orally and is absorbed in intestine,and the risk of infection is reduced; and the detection for the lipid level of the patients in the operative period for every day is not needed so that the treatment cost is reduced. When the invention is taken orally for every day, the purpose of correcting immunologic derangement of the patients in the operative period can be achieved in a short period (3-10 days), and the risk of bleeding is avoided at the same time. The invention has significant and beneficial clinical effects for infection, the length of stay, prognosis, and the like of the patients in the operative period.

Description

technical field [0001] The present invention relates to the application of high-purity EPA-E and polyenoic acid ethyl ester of DHA-E, in particular to its application in the preparation of nutritional supplements for patients during operation. Background technique [0002] EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) are mainly found in marine fish oil and cannot be synthesized by the human body. [0003] Existing polyenoic acid ethyl ester soft capsule is a kind of hypolipidemic medicine, and main component is eicosapentaenoic acid ethyl ester (EPA-E) and docosahexaenoic acid ethyl ester (DHA-E), oral administration It can be converted into eicosapentaenoic acid ethyl ester (EPA) and docosahexaenoic acid ethyl ester (DHA) in the body. The two contain more unsaturated chains, have a strong effect of lowering blood fat, and also have the effect of expanding blood vessels and antithrombotic effect. The effect and mechanism are to promote the release of neutral o...

AI Technical Summary

Problems solved by technology

[0017] At present, if patients need to supplement enough EPA and DHA during the operation period, they must make fish oil into emulsion and mix it with other products (such as protein suspension), and they need to take a large amount of fish oil, which contains more than twice the impurities of EPA and DHA. These impurities are not beneficial or even harmful to patients during surgery

At the same time, the amount of fish oil is limited by the amount of other products (such as protein suspension), and the amount of EPA and DHA cannot be adjusted according to the patient's condition and body weight during the operation. Excessive supply can lead to protein metabolism disorder, increase the burden on organs, and produce side effects , reducing the supply will affect the healing effect

[0018] In conclusion, there is currently no report on the use of high-purity EPA-E and DHA-E polyenoic acid ethyl esters as nutritional supplements for patients during surgery.

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