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Composite glycyrrhizic acid amino acid injection, and preparation method as well as applications thereof

A technology of amino acid and glycyrrhizic acid, which is applied in the direction of pharmaceutical formulations, drug combinations, active ingredients of anhydride/acid/halide, etc., can solve the problems of side effects of hyperaldosteronism, inability to exert curative effect immediately, slow biotransformation, etc., and achieve good therapeutic effect , high product yield and simple process

Inactive Publication Date: 2010-03-17
杭州市第六人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, 18β-glycyrrhizin has a high polarity, poor absorption in the digestive tract, slow biotransformation in the body, and cannot immediately exert curative effect; at the same time, the existing 18β-glycyrrhizin injection contains sodium chloride, and hyperaldosteronism will occur when it is used Side effects; drug-induced hypertension, hypokalemia, and edema can be caused when medication is used for a long period of time or in large doses, while existing marketed products contain relatively high levels of Na + It will also further promote the generation of hyperaldosteronism, so that the clinical application is limited
[0004] There is currently no better drug that can properly address this problem

Method used

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  • Composite glycyrrhizic acid amino acid injection, and preparation method as well as applications thereof
  • Composite glycyrrhizic acid amino acid injection, and preparation method as well as applications thereof
  • Composite glycyrrhizic acid amino acid injection, and preparation method as well as applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Take by weighing 0.375kg of compound glycyrrhizic acid (wherein 18α-glycyrrhizin 0.281kg, 18β-glycyrrhizin 0.094kg), drop into 100L of water for injection, stir and dissolve; add tromethamine 40g, stir; Add 0.2kg of cysteine, 3kg of aminoacetic acid, and 8kg of xylitol to dissolve; add water for injection to make up to 250L, stir well, adjust the pH value of the solution to 6.5, stir well, filter, and fill in a 100ml infusion bottle , stoppering, capping, and sterilizing at 115°C for 30 minutes. The preparation yield is 99.5%.

Embodiment 2

[0031] Take by weighing 0.3kg of compound glycyrrhizic acid (wherein 18α-glycyrrhizin 0.25kg, 18β-glycyrrhizin 0.05kg), drop into 100L of water for injection, stir and dissolve; add 30g of arginine salt, stir; then add to the mixed solution Add 0.2kg of acetylcysteine, 2kg of aminoacetic acid, and 5kg of xylitol to dissolve; add water for injection to make up to 250L, stir well, adjust the pH value of the solution to 6.0, filter, stir well, filter, and fill in In a 100ml infusion bottle, stopper and cover, and sterilize at 115°C for 30min. The preparation yield is 99.1%.

Embodiment 3

[0033] Take by weighing 0.15kg of compound glycyrrhizic acid (wherein 0.1kg of 18α-glycyrrhizin, 0.05kg of 18β-glycyrrhizin), drop into 100L of water for injection, stir and dissolve; add 10g of lysine salt, stir; Add 0.05kg of taurine, 1kg of alanine and 3kg of xylitol, stir and dissolve; add water for injection to make up to 250L, stir well, adjust the pH value of the solution to 7.0; filter, stir well, filter, pour Put it in a 100ml infusion bottle, stopper and cover, and sterilize at 115°C for 30min. The preparation yield is 99.3%.

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Abstract

The invention belongs to the technical field of medicines, in particular to a composite glycyrrhizic acid amino acid injection, and simultaneously, the invention also relates to a method for preparingthe injection and applications thereof in medicines. The invention aims at providing the composite glycyrrhizic acid amino acid injection which has obvious functions of anti-inflammation, antianaphylaxis, oxidation resistance, antiatheroscloresis, immune regulation and detoxication, and also has the characteristics of good product quality, safe and reliable taking and the like; and the method hasthe characteristics of simple technological process and high product yield. The technical scheme provides the composite glycyrrhizic acid amino acid injection which is characterized by being preparedby following crude drug by weight percent: 0.05-0.4% of composite glycyrrhizic acid, 1.05-3.2% of acid amino, 3-8% of xylitol, 0.01-0.05% of pH modifier, and the balance of water for injection.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a compound glycyrrhizic acid amino acid injection, and meanwhile, the invention also relates to a method for preparing the injection and its application in medicines. Background technique [0002] Glycyrrhizic acid is the main active ingredient in licorice, and there are two stereoisomers of glycyrrhizin in nature (18α-glycyrrhizin, 18β-glycyrrhizin). 18β-Glycyrrhizin is commonly referred to as Glycyrrhizin, and 18α-Glycyrrhizin is commonly referred to as Isoglycyrrhizin. The glycyrrhizin saponins in licorice are mainly glycyrrhizin, and only a small amount of isoglycyrrhizin is contained in the rhizome of licorice. Glycyrrhizin has a variety of pharmacological activities, and is widely used clinically for anti-inflammation, liver protection and detoxification. Currently, 18β-glycyrrhizin is widely used in the market. [0003] Clinical trials have confirmed that the use of 18...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K31/198A61K31/185A61K9/08A61P29/00A61P37/08A61P39/06A61P3/06A61P37/02A61P39/02A61P11/06A61P11/00
Inventor 庄让笑娄国强梁伟峰王福根方红英邵益丹
Owner 杭州市第六人民医院
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