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Application of phlorizin in preparing hepatic or health-care food

A health-care food and application technology, applied in the field of preparing liver-protecting medicine or health-care food, can solve problems such as no reported phloretin or phloretin, and achieve the effects of good effect, low toxicity and improving dizziness

Active Publication Date: 2011-09-07
YICHANG HUMANWELL PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are no related reports on the use of phlorizin or phloretin for liver protection

Method used

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  • Application of phlorizin in preparing hepatic or health-care food
  • Application of phlorizin in preparing hepatic or health-care food
  • Application of phlorizin in preparing hepatic or health-care food

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 3

[0016] Example 3 Preparation method of phlorizin

[0017] Take crabapple (one of Malus hupehensis Rehd., Malus Halliana Koehne, and Malus toringoides (Rehd.) Hughes), use water extraction or alcohol extraction extract, and apply macroporous adsorption resin, respectively. Elute with 20%, 50%, 80% (v / v) ethanol. Take 50% ethanol eluate and elute through silica gel column chromatography, recrystallize from ethanol to obtain phlorizin.

[0018] The extraction and separation method of phlorizin can also be prepared into phlorizin with higher purity according to the method reported in the literature.

[0019] Prove effective effect of the present invention by pharmacodynamic test below.

[0020] Experimental raw materials:

[0021] Phloridzin, Phloretin. Natural product research and utilization Hubei Provincial Key Laboratory of self-made.

[0022] Experimental animals: Kunming mice, body weight (10±2) g, (20±2) g, both sexes are male, Balb / c mice, male and female, 5-6 weeks o...

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Abstract

The invention provides application of a compound shown in a general formula I in preparing a hepatic or health-care food. The invention also provides a pharmaceutical composition containing the compound shown in the general formula I. The medicament belongs to a pure natural preparation, is safe and reliable, is developed from food, has small toxicity, and has no adverse reaction after being usedfor a long time; the medicament can be drunk as tea, and has convenient use and delicious taste; the medicament has protection effect on hepatic injury caused by various reasons, and has prevention and treatment effects on various diseases caused by the hepatic injury; and the medicament has good effect on treating or preventing acute alcoholism, and can obviously improve various symptoms caused by alcoholic intoxication such as dizziness, headache, hypodynamia and the like.

Description

technical field [0001] The present invention relates to a new application of the compound described in general formula I, specifically, application in the preparation of liver protection medicine or health food. Background technique [0002] Phloridzin molecular formula: C21H24O10, structural formula (Phloridzin dihydrate): 1-[2-(β-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone; Phloretin 2 `-β-D-glucopyranoside; Phloretin 2`-β-D-glucoside, alias: Phloretin-2`-β-glucoside: phloretion-2`-β-glucoside Chinese alias: 4,6-dihydroxy- 2-(6-gluconoside)-6-(p-hydroxyphenyl)propiophenone, flolicin, which is the 2'-β-D-glucoside of Phloretin (Figure 1), belongs to the plant Compared with other flavonoids, dihydrochalcone glycosides in flavonoids, dihydrochalcones rarely exist in nature and are called "minority flavonoids". Phlorizin is mainly found in the root bark, stem, young leaves and fruits of apples, and is isolated from other plants such as the compo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7034A61K31/12A61P1/16A61P31/12A61P31/20A61P39/02A23L1/30A23L33/105
Inventor 汪鋆植薛冰洁邹坤郭志勇王晓梅叶红杨进周媛
Owner YICHANG HUMANWELL PHARMA