Doxycycline hydrochloride oral disintegrating tablet for domestic fowls and preparation method thereof

Abstract

The invention relates to a doxycycline hydrochloride oral disintegrating tablet for domestic fowls and a preparation method thereof, wherein the composing components of the oral disintegrating tablet and the parts by weight thereof are respectively that 30-150 parts of doxycycline hydrochloride, 60-150 parts of microcrystalline cellulose, 25-60 parts of low-substituted hydroxypropyl cellulose, 50-120 parts of lactose, 30-100 parts of esibatan, 10-30 parts of milk king essence, 0.3-1 parts of saccharin sodium, and 1-3 parts of magnesium stearate. The oral disintegrating tablet has the advantages that manufacturing devices are simple, the operation is easy, the weight difference is small, and the cost is low, and breaks the conventional rule of just using freeze-dry technology to produce oral disintegrating tablets, opens up the technology for producing the oral disintegrating tablet just through adopting common powder type granule tablets in China, is an important breakthrough of the processing technology of preparations for oral use in China, and opens new possibilities in emergency treatment of animal drug markets in China.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, in particular to a doxycycline hydrochloride orally disintegrating tablet for livestock and poultry and a preparation method thereof. Background technique [0002] With the rapid development of my country's livestock and poultry breeding industry and the continuous development of veterinary drug research, the application of antibiotics in the treatment of various diseases and infections of livestock and poultry has become common, which is of great importance to the improvement of the survival rate and health level of livestock and poultry as well as the effective control and treatment of diseases. played a positive role. Doxycycline hydrochloride is a tetracycline antibiotic, its antibacterial spectrum is similar to other tetracyclines, and its antibacterial activity in vitro and in vivo is stronger than that of oxytetracycline and tetracycline. It is mainly used for the treatment of...

AI Technical Summary

Problems solved by technology

[0004] Doxycycline hydrochloride orally disintegrating tablets have not been produced at home and abroad, and there is no development of this product. Therefore, there is an urgent need to develop one and a series of drugs that are convenient to administer, do not need to be given water, absorb quickly, and are bioavailable. Veterinary drug products with high concentration, taking method, good taste, less intestinal residues, low side effects, avoiding the first-pass effect of the liver, or requiring only a small amount of water and no need to chew, so as to make up for the gap in the domestic veterinary drug market in terms of dosage forms, and to treat livestock and poultry Emergency-specific drug for serious infections opens new avenue