Natural macromolecular ultrafine fibrous membrane marked with radioactive nuclide and preparation method thereof
A technology of natural macromolecules and radionuclides, applied in the field of macromolecular ultra-fine fiber membranes, can solve the problem of no targeted drug delivery carrier, etc., and achieve the effect of broad application prospects.
Active Publication Date: 2013-01-02
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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Problems solved by technology
Radionuclide internal radiation therapy is a promising tumor targeting therapy, but there is still no targeted drug delivery carrier with recognized clinical efficacy
Method used
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Embodiment 1
[0028] (1) 0.5g chitosan (deacetylation degree is greater than 97%, molecular weight 200,000) is dissolved in the mixed solvent of 10ml acetic acid and water (the volume ratio of acetic acid and water is 9: 1), is prepared into chitosan quality An electrospinning solution with a concentration of 5%;
[0029] (2) The electrospinning solution of step (1) is loaded into the feeding injector of the electrospinning equipment, selects the double spinneret device connected with the injector, selects the rotating drum as the collector; adjusts the double spinneret and the rotation The distance between the drums is 12cm, the ambient temperature of spinning is 25°C, and the air velocity in the environment is controlled at 0.5-0.8m 3 / hr; turn on the high-voltage power supply and the feeding syringe pump, carry out electrospinning under the conditions of voltage 20KV and feeding rate 20ul / min, obtain chitosan ultrafine fiber membrane on the rotating drum, and scan it with an electron mic...
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Abstract
The invention discloses a natural macromolecular ultrafine fibrous membrane marked with radioactive nuclide and a preparation method thereof. The preparation method mainly comprises the following steps: firstly, electrostatially spinning biodegradable and absorbable natural biological macromolecules to prepare a natural macromolecular ultrafine fibrous membrane; carrying out a crosslinking reaction on the surface of the natural macromolecular ultrafine fibrous membrane; introducing a bifunctional group binder to the natural macromolecular ultrafine fibrous membrane by a coupling reaction; andfinally, realizing the load of radioactive nuclides in a natural macromolecular ultrafine fibrous membrane material by a chelation reaction. The natural macromolecular ultrafine fibrous membrane material marked with radioactive nuclide has favorable biocompatibility, can be implanted in a tumor in a human body or a lesion site after the resection of the tumor for killing residual tumor cells by the inner radiation action of the radioactive nuclides to realize the effect of adjuvant therapy; and the natural macromolecular ultrafine fibrous membrane material marked with radioactive nuclide can be biodegraded and absorbed on the other hand, thereby being a biological material with wide application prospects.
Description
technical field [0001] The invention belongs to the field of polymer ultrafine fiber membranes containing radionuclides, and in particular relates to a radionuclide-labeled natural polymer ultrafine fiber membrane and a preparation method thereof. Background technique [0002] Generally, fibers with a diameter of less than 5 microns are called ultrafine fibers. Ultrafine fibers have the characteristics of high porosity and high specific surface area, and are especially suitable for biomedical fields. Electrospinning is a processing technology that uses the action of high-voltage electric field to prepare polymer solution or melt spinning into micron-scale to nano-scale ultra-fine fibers. It is currently the most common method for preparing polymer ultra-fine fiber membranes. , processing medical polymers into ultrafine fiber membranes can be widely used in many fields such as tissue repair, cell scaffolds, drug carriers, and artificial skin. Internal radionuclide radiation ...
Claims
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IPC IPC(8): A61K51/06A61P35/00D01F4/00D01F9/00
Inventor 韩志超许杉杉聂华荣李军星
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS