Thermal response-type ultrafine fiber film material and preparation method thereof

A technology of ultra-fine fibers and membrane materials, applied in the directions of fiber processing, fiber chemical characteristics, filament/thread forming, etc., can solve the problems of fiber membrane rupture and dispersion, and achieve good biocompatibility, simple and effective method, and good ventilation. Effect

Active Publication Date: 2010-05-12
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although many solvents can realize the electrospinning of P-NIPA, due to the lack of intramolecular and intrafiber crosslinking points, the obtained fiber material will dissolve in water quickly at a temperature lower than the LCST, even if it is higher than the LCST, the fiber The membrane will also rupture and disperse in water

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The poly-N-isopropylacrylamide with a mole percentage of 97% and the octadecyl acrylate with a mole percentage of 3% were synthesized by a conventional free radical polymerization method to synthesize poly-N-isopropylacrylamide A copolymer of octaalkyl acrylate, the weight average molecular weight (Mw) of the copolymer is 47,000. Dissolve the copolymer in methanol, stir at room temperature to prepare a homogeneous transparent solution with a mass percent concentration of 25%; inject the above-mentioned homogeneous and transparent mixed solution into an electrospinning device for electrospinning. 50μL / min, the receiving distance is 15cm, and the poly-N-isopropylacrylamide polymer microfiber membrane material that can be used as a temperature-sensitive drug carrier is obtained. The ultrafine fiber membrane is composed of smooth fibers, and the average diameter of the fibers is 0.3 μm. The lower critical solution temperature LCST of the membrane material is 23°C.

Embodiment 2

[0017] Synthesize poly-N-isopropylacrylamide and octadecyl acrylate with a molar percentage of 95% and octadecyl acrylate with a molar percentage of 5% using a conventional free radical polymerization method. A copolymer of octaalkyl acrylate, the weight average molecular weight (Mw) of the copolymer is 47,000. Dissolve the copolymer in methanol, stir at room temperature to prepare a homogeneous transparent solution with a mass percent concentration of 25%; inject the above-mentioned homogeneous and transparent mixed solution into an electrospinning device for electrospinning. 50μL / min, the receiving distance is 15cm, and the poly-N-isopropylacrylamide polymer microfiber membrane material that can be used as a temperature-sensitive drug carrier is obtained. The microfiber membrane is composed of smooth fibers, and the average diameter of the fibers is 0.3 μm. The lower critical solution temperature LCST of the membrane material is 23°C.

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Abstract

The invention discloses a thermal response-type ultrafine fiber film material and a preparation method thereof. The formula of the material comprises the following components in mol percentage content: 93-98% of poly-N-isopropylacrylamide, and 2-7% of long chain alkyl acrylate. The preparation method of the thermal response-type ultrafine fiber film material comprises the following steps: a) dissolving the polymer with the above proportion in methanol, stirring at room temperature, and preparing into uniform transparent solution; and b) injecting the above uniform transparent solution in an electrostatic spinning device for electrostatic spinning. The invention has the advantages that the method can control the density of physical crosslink points in fibers after electro spinning, and obtain thermal response-type ultrafine fiber film materials with different temperature response ranges and different volume changing scale. The material has the advantage of good biological compatibility, light weight and softness, good permeability and the like, and can be used as a carrier of temperature sensitive medicines. The preparation method is effective, adopts conventional radical polymerization to synthesize polymer with a dewatering side chain, effectively enlarges the temperature range of LCST, and leads the thermal respond process to be more controllable.

Description

technical field [0001] The invention relates to the field of biocompatible polymer non-woven materials, in particular to a heat-responsive superfine fiber membrane material and a preparation method thereof. Background technique [0002] The volume of polymer gels will be affected by various environmental factors, such as temperature, solvent environment, pH value, applied electric field, light and so on. Poly N-isopropylacrylamide (P-NIPA) is a typical heat-responsive polymer, and its lower critical solution temperature (LCST, lower critical solution temperature) in aqueous solution is 32°C. The rapid change of gel volume is very important in practical applications, such as sensors, actuators, drug carriers, cell engineering, etc., so P-NIPA also has broad application prospects in these fields. [0003] Electrospinning is a simple and effective method for preparing nanoscale fibers. By placing various polymer solutions or melts under a high-voltage electrostatic field and c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F265/10D01F6/28D01D5/00
Inventor 韩志超许杉杉申孟芝李立藏
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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