Polymethacrylic acid magnetic composite microspheres and preparation method thereof

A technology of magnetic composite microspheres and polymethacrylic acid, applied in the field of polymers, to achieve the effects of convenient operation, great flexibility, simple equipment and processes

Active Publication Date: 2011-12-28
XIAN GOLDMAG NANOBIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The micron-scale magnetic polymer microspheres containing active functional groups disclosed above have certain deficiencies in sphericity, monodispersity or magnetic content, etc.

Method used

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  • Polymethacrylic acid magnetic composite microspheres and preparation method thereof
  • Polymethacrylic acid magnetic composite microspheres and preparation method thereof
  • Polymethacrylic acid magnetic composite microspheres and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 1) In a three-neck flask equipped with an electric stirrer, dissolve 0.5g of Span80 in 60ml of toluene, under the condition of nitrogen protection, the system reacts for 30min while stirring, and the reaction temperature is 20°C;

[0034] 2) Under the condition of nitrogen protection, dissolve 1ml of methacrylic acid and 0.1g of N,N'-methylene bisacrylamide in 5ml of secondary water to prepare a solution, and add the solution to the system of step 1) , then add 1ml (5 ~ 100mg / ml) of Fe 3 o 4 , and 1ml of potassium persulfate, the system reacted for 10 minutes while stirring, and the reaction temperature was 30°C;

[0035] 3) Under the condition of nitrogen protection, add 1ml of tetramethylethylenediamine dropwise to the system of step 2), react at 40°C for 2h, and wash repeatedly with secondary water and ethanol to obtain polymethacrylic acid magnetic Composite microspheres.

Embodiment 2

[0038] 1) In a three-neck flask equipped with an electric stirrer, dissolve 0.4g Span80 in 60ml of toluene, under the condition of nitrogen protection, the system reacts for 30min while stirring, and the reaction temperature is 20°C;

[0039] 2) Under the condition of nitrogen protection, dissolve 1ml of methacrylic acid and 0.15g of N,N'-methylenebisacrylamide in 5ml of secondary water to prepare a solution, and add the solution to the system of step 1) , then add 1ml (5 ~ 100mg / ml) of Fe 3 o 4 , and 1ml of potassium persulfate, the system reacted for 30 minutes while stirring, and the reaction temperature was 20°C;

[0040] 3) Under the condition of nitrogen protection, add 1ml of tetrabutylammonium bromide dropwise to the system of step 2), react at 40°C for 3h, and wash repeatedly with secondary water and ethanol to obtain polymethacrylic acid magnetic Composite microspheres.

[0041] image 3 (a), (b) is the scanning electron micrograph of the polymethacrylic acid mag...

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Abstract

The invention relates to a polymethacrylic acid magnetic composite microsphere and a preparation method thereof. The microsphere is a composite microsphere with a core-shell structure, the inner polymer channel contains superparamagnetic nanoparticles to form a multi-core core part, and the outer part is formed by cross-linked methacrylic acid to form a shell layer covering the core part. The microsphere preparation method comprises: under the protection of an inert gas, mixing a surfactant and an organic solvent, stirring at 15-40° C. for 30-90 minutes; adding methacrylic acid, a cross-linking agent, magnetic nanoparticles and an initiator, Stir at ~40°C for 10-60 minutes; then add accelerator, stir and react at 20-50°C for 1.5-8 hours to prepare the microspheres. The particle size of the polymethacrylic acid magnetic composite microsphere is uniform, the magnetic content is controllable, and the size of the particle size can be controlled by controlling the reaction conditions; the equipment and process used for preparing the polymethacrylic acid magnetic composite microsphere are simple, and the operation is convenient. Great flexibility.

Description

technical field [0001] The invention relates to the technical field of polymers, in particular to a polymethacrylic acid magnetic composite microsphere and a preparation method thereof. Background technique [0002] Magnetic polymer microsphere refers to a composite microsphere formed by combining inorganic magnetic particles and organic polymer materials. Functional groups coupled with biologically active substances are introduced through copolymerization and surface modification, and have superparamagnetic properties. It can complete repeated separation operations under the action of a magnetic field, so magnetic polymer microspheres containing active functional groups are widely used as magnetic carriers. Magnetic polymer microspheres carrying carboxyl groups can be connected to polypeptides, proteins and biological enzymes through carboxyl groups, and can also be modified to connect other functional groups. It is an ideal magnetic carrier. [0003] Fe prepared by co-pre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F2/44C08K3/22C08L33/02C08K3/08
Inventor 崔亚丽崔婷胡道道陈超
Owner XIAN GOLDMAG NANOBIOTECH
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