Soft capsule used for clearing away heat and toxic materials and preparation method thereof

A technology of soft capsules and extract powder, which is applied in capsule delivery, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve problems such as lack of specificity, human hazards, and inconvenience of taking granules, and improve the quality of drugs , Improve drug stability, shorten the effect of disintegration time limit

Active Publication Date: 2010-05-26
HAINAN HAISHEN TONGZHOU PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are granules, hard capsules and soft capsules in Yiqing preparations. The granules are inconvenient to take, and the taste of the hard capsules is not good, and the bioactive ingredients in the granules or hard capsules have low availability, poor sealing performance, and inaccurate content, etc. ; At the same time, the current granule quality standard only uses the chemical reference substance as a contrast in the identification item, and no contrast medicinal material as a contrast, which lacks spec

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Add 330g of rhubarb rhizome, 1000g of rhubarb rhubarb, and 500g of scutellaria baicalensis to decoct twice, the first time for 1.5 hours, and the second time for 1 hour, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a clear liquid with a relative density of 1.18 (75°C). paste, spray-dried to make coptis powder, rhubarb powder, and scutellaria baicalensis powder; mix the three extract powders to obtain a clear extract powder.

[0016] In terms of weight ratio, take 20 parts of Yiqing extract, 20 parts of peanut oil, 0.5 part of soybean lecithin, and 1 part of beeswax and mix them uniformly to make a suspension; get gelatin, glycerin and water in a ratio of 0.35:1:1 by weight, The rubber is prepared by the traditional method, then the suspension is poured and pressed into 1000 soft capsules, the shape is set below 20°C, the oil layer on the surface of the soft capsule is wiped off with a fiber-free rag, and the product is obtained by...

Embodiment 2

[0018] Add 3.3kg of rhubarb rhizome, 10.0kg of rhubarb, and 5.0kg of scutellaria baicalensis to decoct twice, the first time for 1.5 hours, the second time for 1 hour, combine the decoctions, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.18 (75°C ) clear paste, spray-dried to make coptis powder, rhubarb powder, and scutellaria baicalensis powder; mix the three extract powders to obtain Yiqing extract powder.

[0019] In terms of weight ratio, take 20 parts of Yiqing extract, 50 parts of corn oil, 2 parts of soybean lecithin, and 4 parts of beeswax and mix them uniformly to make a suspension; take gelatin, glycerin and water in a ratio of 0.45:1:1 by weight , using the traditional method to prepare rubber, then pour the suspension into 10,000 soft capsules, set the shape below 23°C, wipe off the oil layer on the surface of the soft capsule with a fiber-free rag, and dry below 28°C to obtain the product.

Embodiment 3

[0021] Add 1.6kg of rhubarb rhizome, 5.0kg of rhubarb, and 2.5kg of scutellaria baicalensis to decoct twice, the first time for 1.5 hours, and the second time for 1 hour, combine the decoctions, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.18 (75°C ) clear paste, spray-dried to make coptis powder, rhubarb powder, and scutellaria baicalensis powder; mix the three extract powders to obtain Yiqing extract powder.

[0022] In terms of weight ratio, take 20 parts of Yiqing extract, 35 parts of palm oil, 1.2 parts of soybean lecithin, and 2.5 parts of beeswax to make a suspension, and take gelatin, glycerin and water in a ratio of 0.50:1:1 by weight. , using the traditional method to prepare rubber, then pour the suspension into 10,000 soft capsules, set the shape below 25°C, wipe off the oil layer on the surface of the soft capsule with a fiber-free rag, and dry below 28°C to obtain the product.

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PUM

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Abstract

The invention discloses a soft capsule used for clearing away heat and toxic materials and a preparation method thereof. The soft capsule is prepared by adopting a traditional preparation process after mixing and preparing clear extract powder, vegetable oil, soybean phosphatide and beeswax into suspension. The preparation method of the soft capsule comprises the following steps: decocting coptis root, rhubarb and baikal skullcap root, preparing a clear paste, then spraying, drying, preparing coptis root powder, rhubarb powder and baikal skullcap root powder and mixing evenly to obtain clear extract powder; mixing the clear extract powder, vegetable oil, soybean phosphatide and beeswax evenly according to the mixture ratio to prepare suspension; and taking gelatin, glycerol and water to prepare gum and then filling and pressing the suspension into the soft capsule. The invention adopts the natural type vegetable oil and the beeswax as a dispersion medium and a suspending agent respectively, enables the medicines to be evenly dispersed, has high utilization degree of the biologic active components of the medicines, enhances the stability of the medicines and the application safety and effectiveness effectively, enshrouds the discomfortable taste of the medicines, is easy to swallow, shortens the disintegration time limit of the soft capsule and enhances the quality standard of the medicines.

Description

technical field [0001] The invention relates to a soft capsule, in particular to a Yiqing soft capsule used for treating mouth and nose sores, sore throat and toothache, dry mouth and tongue and a preparation method thereof. Background technique [0002] The so-called fiery disease in traditional Chinese medicine, that is, "getting angry", is a common disease. This kind of disease is mainly a kind of disease in which the relevant functions of the human body are abnormally excited after the pathogenic factors act on the body. Symptoms include mouth and nose sores, sore throat and toothache, dry mouth, constipation, red and yellow urine and other symptoms. [0003] Yiqing preparation is prepared by extracting Coptidis rhizome, rhubarb and scutellaria baicalensis as the main raw materials. Coptis chinensis has the effects of clearing away heat and dampness, purging fire and detoxifying; Heat-clearing and damp-drying, purging fire and detoxification, hemostasis, the effect of a...

Claims

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Application Information

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IPC IPC(8): A61K36/718A61K9/48A61P1/02A61P11/04A61P17/10
Inventor 戴金林潘银霞査齐国刘世春于晓顺
Owner HAINAN HAISHEN TONGZHOU PHARM CO LTD
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