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Method for extracting high-content lutein by utilizing molecular distillation technology and simulated moving bed technology

A technology of simulating moving bed and molecular distillation, which is applied in the field of extracting high-content lutein, can solve the problems that lutein crystals are not suitable for human consumption, difficult separation and purification operations, and high viscosity of organic solvents, so as to improve the level of automation and Production efficiency, solvent saving, natural quality effect

Active Publication Date: 2010-05-26
天津市尖峰天然产物研究开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There are many ways to produce lutein. Traditional production processes usually use organic solvents. These solvents are difficult or impossible to completely remove, resulting in lutein crystals that are not suitable for human consumption.
At the same time, due to the relatively high viscosity of the applicable organic solvent, the operation in the separation and purification process is relatively difficult. In order to obtain high-content crystals, multiple crystallization processes are required, which is not suitable for industrial production and has the disadvantage of low lutein yield.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A method for extracting high-content lutein by molecular distillation and simulated moving bed technology, comprising the steps of:

[0032] (1) 5kg of commercially available lutein content of 5% marigold extract (Qingdao Sai special product marigold extract) plus 3L volume percentage concentration is 98% ethanol aqueous solution, at 45 ℃, under stirring, extract 2 Hour, extract altogether 3 times, combine extraction solution to concentrate under reduced pressure and reclaim solvent to obtain concentrate;

[0033] (2) Mix the concentrate with camellia oil in a volume ratio of 1:4, and the vacuum degree is 20Pa, the distillation temperature is 90°C, the material flow rate is 3ml / min, the condensation surface temperature is 25°C, and the speed of the scraping film is 400r.p.m., under the condition of circulating water temperature 70°C, perform I-level molecular distillation to remove solvent;

[0034] (3) The vacuum degree of the first-stage molecular distillation and de...

Embodiment 2

[0050] A method for extracting high-content lutein by molecular distillation and simulated moving bed technology, comprising the steps of:

[0051] (1) Detect with HPLC, add the acetone of 3 mass times in the marigold extract that lutein mass content is greater than 5%, at 50 DEG C, under agitation, extract 2 hours, repeat extraction 2 times, combine extraction solution and reduce Concentrate under pressure and recover the solvent to obtain a concentrate;

[0052] (2) The concentrate is mixed with olive oil at a ratio of 1:4 by volume, the vacuum is 10Pa, the distillation temperature is 90°C, the material flow rate is 3ml / min, the condensation surface temperature is 25°C, and the speed of the scraping film is 260r.p.m., under the condition of circulating water temperature 75°C, carry out I-stage molecular distillation desolventization;

[0053] (3) the material after the first-stage molecular distillation and desolventization is 10 in a vacuum degree -1 Pa, the distillation ...

Embodiment 3

[0067] A method for extracting high-content lutein by molecular distillation and simulated moving bed technology, comprising the steps of:

[0068] (1) Add 4 mass times of ethyl acetate to the marigold extract whose lutein mass content is greater than 10% by HPLC, extract for 1 hour at 45°C under stirring, repeat the extraction 3 times, and combine the extractions The liquid is concentrated under reduced pressure to recover the solvent to obtain a concentrate;

[0069] (2) Mix the concentrate with camellia oil in a volume ratio of 1:5, the vacuum is 15Pa, the distillation temperature is 95°C, the material flow rate is 2ml / min, the condensation surface temperature is 25°C, and the speed of the scraping film is Under the condition of 250r.p.m. and circulating water temperature of 80℃, the first-stage molecular distillation desolventization is carried out;

[0070] (3) The vacuum degree of the material after desolvation by I-level molecular distillation is 1Pa, the distillation ...

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Abstract

The invention discloses a method for extracting high-content lutein by utilizing a molecular distillation technology and a simulated moving bed technology. The method comprises the following steps of: adding an organic solvent to a marigold extract and then extracting to obtain a condensate; carrying out primary molecular distillation and secondary molecular distillation on the condensate; dissolving distillates with petroleum ether, extracting with ethanol water and merging ethanol water layers; concentrating by decompression and drying to obtain orange red oily lutein the lutein content of which is higher than or equal to 50 percent; and then purifying the lutein with the simulated moving bed technology to obtain the high-content lutein the quality content of which is 85-95 percent. Themethod can save a great quantity of solvent, lowers the requirements on equipment, reduces the pollution to the environment and can not bring new impurities and toxic substances, thereby being suitable for industrial big production. The lutein obtained by the method has high purity and high yield.

Description

technical field [0001] The invention relates to a method for extracting high-content lutein by molecular distillation and simulated moving bed technology. Background technique [0002] Molecular Distillation is a distillation method operated under high vacuum. At this time, the mean free path of vapor molecules is greater than the distance between the evaporation surface and the condensation surface, so that the difference in evaporation rate of each component in the feed liquid can be used , to separate the liquid mixture. This technology has three advantages: low distillation temperature, high working vacuum, and short material heating time, so it is especially suitable for the separation of high boiling point, heat sensitive and easily oxidized substances. [0003] The simulated moving bed chromatography system uses a solenoid valve to control the change of the inlet to "simulate" the effect of the moving bed, so that the advantages of chromatography can be preserved and...

Claims

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Application Information

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IPC IPC(8): C07C403/24B01D15/10B01D3/12
Inventor 刘莹孙华庚刘丹於洪建
Owner 天津市尖峰天然产物研究开发有限公司
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