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Auricularia auricular composition and auricularia auricula chewable tablets prepared from same

A kind of black fungus and chewable tablet technology, which is applied in the direction of drug combination, anhydride/acid/halide active ingredients, organic active ingredients, etc., can solve the problems of the preparation process and quality gap in the variety of traditional Chinese medicine chewable tablets, and achieve low cost and reduced Side effects, the effect of high crushing fineness

Active Publication Date: 2010-06-16
哈尔滨东方制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with Western medicine, there is a big gap in the number of varieties, preparation process and quality of Chinese medicine chewable tablets

Method used

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  • Auricularia auricular composition and auricularia auricula chewable tablets prepared from same
  • Auricularia auricular composition and auricularia auricula chewable tablets prepared from same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] 1 Materials and reagents

[0076] Black fungus (choose black fungus from Lishui, code AA1; black fungus from Zhejiang, code AA2; northeast China, code AA3; northeast autumn fungus, code AA4; Zhejiang black fungus, code AA5; Shaanxi black fungus, No. AA6; black fungus produced in Northeast China, No. AA7); absolute ethanol, concentrated sulfuric acid, glucose, phenol ferrous amine sulfate [FeNH 4 (SO 4 ) 2 12H 2 O], 1,10-phenanthroline (C 12 h 8 N 2 ·H 2 O), hydroxylamine hydrochloride, concentrated nitric acid, and anhydrous sodium acetate were all analytically pure.

[0077] 2 experimental equipment

[0078] UV-2000 ultraviolet spectrophotometer; HMB-701 ultrafine pulverizer; HELDS / BF laser particle size analyzer; RE-52A rotary evaporator; WVD-01 microwave vacuum drying oven.

[0079] 3 Experimental methods and results

[0080] 3.1 Black fungus crushing process

[0081] Get the black fungus of 200g, after ordinary mechanical coarse pulverization, sieve with ...

Embodiment 2

[0122] Example 2: Effects of Black Fungus Particle Size on Sensory and Iron Dissolution of Chewable Tablets

[0123] Prepare black fungus chewable tablets according to the preparation process of 3.5 chewable tablets, the difference is that the raw material black fungus superfine powder 27g is changed to black fungus powder that has been coarsely crushed by ordinary machinery and passed through a 40-mesh standard sieve, and other conditions and operations are the same as in Example 1 Step, the black fungus chewable tablet that makes is done the dissolution test of iron in the chewable tablet according to YY / T 0188.10-1995, adopts step (3) in 3.2 to measure the total iron content of dissolution. Table 2 shows the comparison results between ordinary mechanically crushed black fungus powder (through a 40-mesh sieve) and ultra-finely crushed black fungus powder.

[0124] Table 2 Effect of particle size of black fungus on sensory and iron dissolution of chewable tablets

[0125] ...

Embodiment 3～6

[0127] Examples 3-6: Determination of the addition ratio of black fungus superfine powder and seaweed powder

[0128] Change the process of 3.5.1, other steps are the same as in Example 1, the larger the proportion of black fungus superfine powder (AASP) and seaweed powder (PP) in the formula, the higher the nutritional value, but also need to consider chewable tablets The molding effect and the need for taste adjustment. The addition amount of superfine powder of black fungus and seaweed powder was changed, and the amount of other raw materials was kept unchanged. Tablet 3 was used for the tabletting test.

[0129] Table 3 Tablet test results of different proportions of black fungus superfine powder and seaweed powder

[0130]

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Abstract

The invention discloses a auricularia auricula composition, which consists of pharmaceutic adjuvant acceptable for human bodies and the following components in part by mass: 18 to 36 parts of auricularia auricula superfine powder, 3 to 12 parts of laver powder, 3 to 12 parts of iron lactate, 0.5 to 2 parts of vitamin B2 and 4 to 12 parts of vitamin C. The invention also discloses auricularia auricula chewable tablets prepared from the auricularia auricula composition. The auricularia auricular composition has the advantages that: fruit bodies of auricularia auricula containing high total ferrum quantity are taken as raw materials; a superfine grinding technique is adopted for the auricularia auricula, the dissolution of nutrients contained in cell walls of the fruit bodies is facilitated, and the bioavailability of the nutrients is improved; and by comparing auricularia auricula powder ground by a common machine with the auricularia auricula superfine powder, the dissolution of ferrum in the chewable tablets is obviously improved.

Description

(1) Technical field [0001] The invention relates to a black fungus composition which can be used to prevent iron-deficiency anemia caused by lack of nutrition and a chewable tablet made thereof. (2) Background technology [0002] Iron is an essential trace element in the human body. When iron is deficient in the body, iron deficiency or iron deficiency anemia will occur, especially for infants, children, pregnant, lactating, and menstrual women over 4 months old. serious. According to the standards of the World Health Organization, anemia accounts for about 30% of the world's population. Over the years, people have been researching and discussing its etiology and prevention measures, among which supplementation is an important and effective way to improve iron deficiency anemia. [0003] For a long time, FeSO has been the first choice clinically 4 preparations for the treatment of iron deficiency anemia, but FeSO 4 It has poor chemical stability, is easily oxidized into ...

Claims

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Application Information

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IPC IPC(8): A61K36/06A61K9/20A61P3/02A61K31/525A61K31/375A61K31/19
Inventor 张拥军何杰民李佳王正郁朱飞飞
Owner 哈尔滨东方制药有限公司
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