Citrate mosapride pill

A technology of mosapride citrate and dripping pills, applied in directions such as sugar-coated pills, pill delivery, digestive system, etc., can solve problems such as no public literature report of mosapride citrate dripping pills, etc., and achieve easy swallowing. high bioavailability, rapid onset effect

Active Publication Date: 2010-06-30
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no public liter

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: This example was prepared by methods known in the pharmaceutical industry.

[0019] composition:

[0020] Mosapride citrate (anhydrous basis) 5g

[0021] Macrogol 4000 95g

[0022]

[0023] Prepared as 1000 pills

[0024] It can be obtained by dripping by conventional methods.

Embodiment 2

[0025] Example 2: This example was prepared by methods known in the pharmaceutical industry.

[0026] composition:

[0027] Mosapride citrate (anhydrous basis) 5g

[0028] Macrogol 4000 5g

[0029] Macrogol 1500 9g

[0030] Sodium carboxymethyl starch 1g

[0031]

[0032] Prepared as 1000 pills

[0033] It can be obtained by dripping by conventional methods.

Embodiment 3

[0034] Embodiment 3: This embodiment is prepared by methods known in the pharmaceutical industry.

[0035] composition:

[0036] Mosapride citrate (anhydrous basis) 5g

[0037] Macrogol 4000 3g

[0038] Macrogol 1500 11g

[0039] Tween 80 1g

[0040]

[0041] Prepared as 1000 pills

[0042] It can be obtained by dripping by conventional methods.

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PUM

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Abstract

The invention relates to a citrate mosapride pill preparation and a preparing method thereof. The preparation has short time limit of dissolution and high velocity of drug release. The pill mainly comprises drugs, pill matrixes and other auxiliary materials. The dropping method for preparing pills has the advantages of simple equipment, convenient operation, short production cycle, accurate dose, small drug consumption in the operation process and stable quality, and can improve the bioavailability of insoluble drugs.

Description

Technical field: [0001] The invention belongs to the technical field of western medicine preparations, and in particular relates to a dripping pill preparation of mosapride citrate, a digestive tract prokinetic agent. Background technique: [0002] Mosapride citrate (Mosapride Citrate) is a new third-generation gastric motility drug, mainly used for the treatment of esophageal reflux disease. The drug can enhance gastrointestinal motility, but does not affect gastric acid secretion, and has no side effects such as extrapyramidal reaction and diarrhea, and is well tolerated. Mosapride citrate is the first selective 5-HT 4 Receptor agonist, which is a benzamide derivative, stimulates 5-HT in the myenteric plexus 4 Receptors, increase the release of acetylcholine from nerve endings, promote gastrointestinal motility and gastric emptying, have strong receptor selectivity, and selectively act on 5-HT 4 receptors, and thus does not antagonize dopamine D compared to metocloprami...

Claims

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Application Information

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IPC IPC(8): A61K31/136A61K9/28A61P1/14
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION
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