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Medical composition containing dextro-Rabeprazole and preparation method thereof

A technology of dextro-rabeprazole and rabeprazole, which is applied in the field of medicine and can solve problems such as research, no preparation prescription, etc.

Inactive Publication Date: 2010-07-07
北京利乐生制药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] At present, the research on dex-rabeprazole is still in the research of pharmacology and pharmacodynamics, and there is no research on the prescription of preparations.

Method used

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  • Medical composition containing dextro-Rabeprazole and preparation method thereof
  • Medical composition containing dextro-Rabeprazole and preparation method thereof
  • Medical composition containing dextro-Rabeprazole and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1 Dexrabeprazole tablet

[0021] prescription:

[0022]

[0023] Preparation:

[0024] Pass dex-rabeprazole and microcrystalline cellulose through 80-mesh sieve respectively, mix evenly, add 50% ethanol solution into the mixed powder, make soft material, granulate with 24-mesh sieve, dry, granulate with 20-mesh sieve, Add micropowder silica gel and CMS-Na, mix evenly, and press a suitable die to form a tablet.

[0025] If the above-mentioned tablet is coated, a coated tablet can be obtained, which can be a film-coated tablet, an enteric-coated tablet, and the like.

Embodiment 2

[0026] Embodiment 2 Dexrabeprazole sodium tablet

[0027] prescription:

[0028]

[0029] Preparation:

[0030] Pass dex-rabeprazole sodium, microcrystalline cellulose, and lactose through 80-mesh sieve respectively, mix well, add 50% ethanol solution to the mixed powder, make soft material, granulate with 24-mesh sieve, dry, 20-mesh sieve For granulation, add micropowder silica gel and CMS-Na, mix evenly, and press a suitable die to form a tablet.

[0031] If the above-mentioned tablet is coated, a coated tablet can be obtained, which can be a film-coated tablet, an enteric-coated tablet, and the like.

Embodiment 3

[0032] Embodiment 3: Dexrabeprazole capsules

[0033] prescription:

[0034]

[0035] Preparation:

[0036] The starch was baked in an oven at 70°C for 10 hours and set aside. Take dextro-rabeprazole and starch and pass through an 80-mesh sieve, mix uniformly according to the method of equal volume addition, add magnesium stearate, mix uniformly, pack separately, and obtain the product.

[0037] The used capsule shell can be a common capsule or an enteric-coated capsule.

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PUM

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Abstract

The invention relates to a medical composition containing dextro-Rabeprazole and a preparation method thereof. The medical composition is prepared by taking dextro-Rabeprazole as the main active constituent and mixing dextro-Rabeprazole with pharmaceutically acceptable auxiliary materials. The composition can be prepared into various oral preparations according to the requirements, such as tablets, capsules, granules, dispersible tablets, chewable tablets, buccal tablets, effervescent tablets, effervescent granules and any other solid formulation, wherein, the unit preparation content of dextro-Rabeprazole is 2-50mg, preferably 10-40mg. The composition of the invention can be used for treating various digestive tract diseases, in particular to peptic ulcer.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing dex-rabeprazole and a preparation method thereof, which is formed by mixing dex-rabeprazole or its salt or its hydrate as the main active ingredient and pharmaceutically acceptable auxiliary materials. It belongs to the field of medical technology. Background technique [0002] The chemical structural formula of rabeprazole is as follows [0003] [0004] In practical applications, we often use its medicinal salts, the most common being sodium salt, magnesium salt and potassium salt. Rabeprazole sodium is a drug that inhibits secretion and is a substitute for benzimidazole. It has no anticholinergic and anti-H2 histamine properties, but it can attach to the surface of gastric parietal cells and inhibit gastric acid production by inhibiting H+ / K+-ATPase secretion. This enzyme system is regarded as an acid proton pump, so rabeprazole sodium acts as a proton pump inhibitor in the stoma...

Claims

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Application Information

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IPC IPC(8): A61K31/4439A61P1/04A61P1/00A61K9/20A61K9/48A61K9/14A61K9/46
Inventor 李宝齐
Owner 北京利乐生制药科技有限公司
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