Preparation for panaxoside-Rd aqueous solution of propylene glycol and new application thereof in inflammation resistance, immune suppression and organ transplant rejection resistance
A technology of ginsenoside and propylene glycol, which is applied in anti-inflammatory agents, plant raw materials, medical preparations of non-active ingredients, etc., and can solve the problem of low content of ginsenoside-Rd
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[0088] Example 1. Study on the formulation of low-concentration ginsenoside-Rd solution with propylene glycol solubilization
[0089] Objective: Adjust the concentration of propylene glycol so that the ginsenoside-Rd can be completely dissolved, in order to obtain a true solution, so as to ensure the safety of clinical medication.
[0090] Method: Use different volume ratios (20 volume %, 30 volume %, 40 volume %, 50 volume %, 55 volume %, 60 volume %, 75 volume% and 100 volume %) propylene glycol aqueous solution as solvent, with 10mg / ml and 5mg Add ginsenoside-Rd to the content of / ml to determine the concentration of propylene glycol that can fully dissolve ginsenoside-Rd. After obtaining the true solution, examine the dissolution state of the drug solution under freezing or cold storage conditions. The usable preparation is diluted with water for injection and then added to 250ml of normal saline to mix well or directly diluted with normal saline to investigate the dissolution...
Example Embodiment
[0140] Example 2. The effect of high concentration propylene glycol on the solubility of high concentration ginsenoside-Rd
[0141] Objective: To increase the concentration of propylene glycol, and to increase the content of ginsenoside-Rd in turn, to investigate the influence of the concentration of propylene glycol on the solubility of ginsenoside-Rd.
[0142] Method: Use propylene glycol with a concentration of ≥50% by volume, and add ginsenoside-Rd with different contents (20mg / ml, 25mg / ml, 50mg / ml, 75mg / ml) [first dissolve the ginsenoside-Rd powder with pure propylene glycol and then Add a certain amount of water (Method B)]. Leave it at room temperature for several days, put the sample with good solution in the refrigerator for refrigeration or freezing, observe the solution state, and detect the Tyndall phenomenon.
[0143] 1. Material (same as Example 1)
[0144] 2. Method
[0145] Propylene glycol with a concentration of ≥50% by volume is selected, and ginsenoside-Rd is added...
Example Embodiment
[0163] Example 3. The effect of ginsenoside-Rd on inflammation
[0164] In this experiment, carrageenan was used as an acute inflammation inducer, and it was injected into mice and rat foot plantar subcutaneously to induce rat and mouse foot swelling models to observe the effect of ginsenoside-Rd on inflammation.
[0165] 1. Animals
[0166] 120 Kunming mice, half male and half male, clean grade, weighing 18-22g, purchased from the Laboratory Animal Center of Lanzhou University, license number: SCXK (甘)20050007; 96 Wistar rats, half male and half male, SPF grade, Weight 180-220g, purchased from the Research and Experimental Center of Gansu College of Traditional Chinese Medicine, license number: SCXK (甘)20040006.
[0167] 2. Medicines
[0168] 2.1 Ginsenoside-Rd: Provided by Guangdong Taihe Biopharmaceutical Co., Ltd., product batch number: 980303, dissolved in 55% propylene glycol one day before use to prepare a solution of corresponding concentration.
[0169] 2.2 Dexamethasone Sodium...
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