Preparation for panaxoside-Rd aqueous solution of propylene glycol and new application thereof in inflammation resistance, immune suppression and organ transplant rejection resistance

A technology of ginsenoside and propylene glycol, which is applied in anti-inflammatory agents, plant raw materials, medical preparations of non-active ingredients, etc., and can solve the problem of low content of ginsenoside-Rd
CN101766640AInactive Publication Date: 2010-07-07LANZHOU UNIVERSITY +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
LANZHOU UNIVERSITY
Publication Date
2010-07-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to preparation for panaxoside-Rd aqueous solution of propylene glycol and new application thereof in inflammation resistance, immune suppression and organ transplant rejection resistance. The invention provides panaxoside-Rd solution and a preparation method thereof. The solution is formed by dissolving the panaxoside-Rd in propylene glycol aqueous solution containing 50 to 100 volume percent of propylene glycol, and the content of the panaxoside-Rd is 1 to 100 mg / ml, wherein the volume percentage of the propylene glycol is based on the total volume of the aqueous solution of propylene glycol. The invention further provides a medicinal composition containing the solution of the invention and a preparation method thereof, and application of the panaxoside-Rd or the panaxoside-Rd solution of the invention in preparing a medicament for inflammation resistance, immune suppression and / or organ transplant rejection resistance.
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Description

technical field

[0001] The invention relates to the technical field of pharmaceutical preparations, more specifically, to a ginsenoside-Rd propylene glycol aqueous solution with high solubility and stability, its preparation, preparation method and application. Background technique

[0002] Ginsenoside-Rd is a monomeric compound obtained by multi-step separation from the traditional Chinese medicine Araliaceae plant Panax notoginseng, and belongs to protopanaxadiol type saponin. Its Chinese chemical name is 20-(S)-protopanaxadiol-3[O-β-D-glucopyranose (1→2)-β-D-glucopyranoside]-20-O-β- D-Glucopyranoside, the English chemical name is 20(S)-Protopanaxadiol 3-O-[β-D-glucopyranosyl(1→2)-β-D-glucopyranosyl]-20-O-β-glucopyranoside, chemical structure as follows:

[0003]

[0004] Ginsenoside-Rd is white to light yellow powder, odorless, easily soluble in methanol, ethanol, propylene glycol, n-butanol and hot water; soluble in acetone, chloroform and water. The main physical ...

Claims

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