Method for preparing alpha-acetyl-gamma-butyrolactone

Abstract

The invention provides a method for preparing alpha-acetyl-gamma-butyrolactone. In the method, gamma-butyrolactone and an acetylating agent (ethyl acetate and methyl acetate or a mixture of ethyl acetate and methyl acetate) are used as starting materials, metal sodium is used as a catalyst, and the product is obtained by acylation, neutralization and distillation. The method has the advantages that: the raw materials are used as the solvent at an initial stage of the reaction, so that the environmental pollution brought by the solvent is lowered, the material feeding amount is increased, the production efficiency is improved, and the production cost is lowered; the metal sodium is added into the reaction system continuously or for several times, so that potential safety risks such as outshoot and combustion caused by difficult control of the reaction speed can be effectively avoided when the sodium metal is reacted at a melting temperature; and by adopting the pressure-regulating distillation method, the byproducts are effectively recovered, the environmental pollution is lowered, and the comprehensive economic benefits are improved.

Description

technical field

[0001] The invention relates to medicine and chemical intermediates, in particular to a preparation method of α-acetyl-γ-butyrolactone. Background technique

[0002] α-acetyl-γ-butyrolactone is an important drug and organic chemical intermediate or raw material, especially as an intermediate for the production of vitamin B1, chloroquine and other drugs. At present, there are mainly two routes for the preparation of α-acetyl-γ-butyrolactone. One is a process using ethylene oxide and ethyl acetoacetate as starting materials, and the other is a process based on γ-butyrolactone. And ethyl acetate as the starting material process.

[0003] US 2443827, CN 135745A, GB 740993, Czechoslovakia patent 95116, special agent Zhao 4212662 bulletin all adopt the synthesis process using ethylene oxide as raw material, but the ethylene oxide as the reaction raw material belongs to the first class flammable and explosive chemical There are serious safety hazards in storage, t...