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Method for preparing dichloro dicyclopentadienyl titanium and cis-platinum nano-particles by atomization ultrasound polarity difference technology

A technology of titanocene dichloride and atomization ultrasound, which is applied in the fields of nano-biomedicine and materials, can solve the problems of narrow anti-tumor system, duration of toxic and side effects, etc., and achieves the effects of controllable production, simple equipment, and difficulty in agglomeration

Inactive Publication Date: 2010-07-14
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This just overcomes the shortcomings of its narrow anti-tumor line, varying degrees of toxic and side effects and short duration.

Method used

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  • Method for preparing dichloro dicyclopentadienyl titanium and cis-platinum nano-particles by atomization ultrasound polarity difference technology
  • Method for preparing dichloro dicyclopentadienyl titanium and cis-platinum nano-particles by atomization ultrasound polarity difference technology
  • Method for preparing dichloro dicyclopentadienyl titanium and cis-platinum nano-particles by atomization ultrasound polarity difference technology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 1) Accurately measure 0.01 g of titanocene dichloride solute with an analytical balance, mix it with 5 mL of chloroform solvent, put it in a clean glass dish and stir until it is completely dissolved under the action of a magnetic stirrer, and dilute it in a volumetric flask to 25mL to obtain solution A. Measure 20 mL of petroleum ether (60-90° C.) solution as the eluent to obtain solvent B.

[0044] 2) Take 2mL of solution A in a squeeze sprayer, and place solvent B in an ultrasonic environment. Spray solution A into solvent B to precipitate. The ambient temperature is controlled at 15-25°C; the ambient humidity is 45%-50%; the ultrasonic intensity is 100W; the mass flow rate of the spray is 0.4-0.5mL / min. After 5 min, the collected nanoparticles were centrifuged and washed.

[0045] 3) Characterize the structure and morphology of the obtained product by XRD, SEM, TEM and other means; test the drug release in vitro of the product; and measure its anticancer performa...

Embodiment 2

[0047] 1) Accurately measure 0.01 g of titanocene dichloride solute with an analytical balance, mix it with 5 mL of chloroform solvent, put it in a clean glass dish and stir until it is completely dissolved under the action of a magnetic stirrer, and dilute it in a volumetric flask to 25mL to obtain solution A. Measure 20 mL of petroleum ether (60-90° C.) solution as the eluent to obtain solvent B.

[0048] 2) Take 2mL of solution A in a squeeze sprayer, and place solvent B in an ultrasonic environment. Spray solution A into solvent B to precipitate. The ambient temperature is controlled at 15-25°C; the ambient humidity is 45%-50%; the ultrasonic intensity is 100W; the mass flow rate of the spray is 0.4-0.5mL / min. After 20 min, the collected nanoparticles were centrifuged and washed.

[0049] 3) Characterize the structure and morphology of the obtained product by XRD, SEM, TEM and other means; test the drug release in vitro of the product; and measure its anticancer perform...

Embodiment 3

[0051] 1) Accurately measure 0.1 g of titanocene dichloride solute with an analytical balance, mix it with 5 mL of chloroform solvent, put it in a clean glass dish and stir it under the action of a magnetic stirrer until it is completely dissolved, and dilute it in a volumetric flask to 25mL to obtain solution A. Measure 20 mL of petroleum ether (60-90° C.) solution as the eluent to obtain solvent B.

[0052] 2) Take 2mL of solution A in a squeeze sprayer, and place solvent B in an ultrasonic environment. Spray solution A into solvent B to precipitate. The ambient temperature is controlled at 15-25°C; the ambient humidity is 45%-50%; the ultrasonic intensity is 100W; the mass flow rate of the spray is 0.4-0.5mL / min. After 5 min, the collected nanoparticles were centrifuged and washed.

[0053] 3) Characterize the structure and morphology of the obtained product by XRD, SEM, TEM and other means; test the drug release in vitro of the product; and measure its anticancer perfor...

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Abstract

Belonging to the field of nano biomedicine and material, the invention in particular relates to the atomization ultrasound polarity difference technology for preparing organic metal anti-cancer drug-dichloro dicyclopentadienyl titanium and cis-platinum nano-particles. The method comprises the following steps: preparing solution A with an appropriate concentration; placing the solution A into a squeezing type sprayer and spraying the solution A into solution B; controlling environment temperature to range from 15 DEG C to 25 DEG C, environment humidity to range from 45% to 50%, ultrasound intensity to be 100w and jet mass velocity to range from 0.4mL / min to 0.5mL / min; wherein the whole reaction system is in an ultrasound environment. The method of the invention features simple equipment, convenient preparation process and low production cost. Medicine size and shape of the product can be controlled by controlling conditions such as medicine concentration in the solution A, reaction time and the like; therefore controlled production of the medicine is expected to be realized by further studies, thus providing more choices for multi-drug administration of the medicine. The method of the invention has the advantages of simple and convenient operation, short production cycle, controlled production, freedom from addition agent and easy realization of industrialization, thus being of great value for industrialized application and expected to be promoted to achieve large-scale application. In addition, the product features even distribution, difficult agglomeration, high purity and easy realization of industrialized production.

Description

technical field [0001] The invention belongs to the technical field of nanobiological medicine and materials, and in particular relates to a method for preparing titanocene dichloride and cisplatin nanoparticles by atomization ultrasonic polarity difference technology. Background technique [0002] Cancer is one of the major diseases that seriously endanger human health, and cancer has become the second largest killer after cardiovascular disease. Conquering cancer has always been a research topic attracting worldwide attention. According to the research of the World Health Organization, the number of cancer patients is increasing year by year. At present, people have conducted extensive research on cancer, especially the research on anticancer drugs. [0003] The western medicine after ultrafine treatment can change the way of administration and strengthen the effect of administration. In drug administration studies, the dosage form is important. The body's absorption, ...

Claims

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Application Information

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IPC IPC(8): B01J2/06C07F17/00C01G55/00A61J3/00
Inventor 张琨吴庆生
Owner TONGJI UNIV
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