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Method for synthesizing gold-coated ferroferric oxide nano particles

A technology of gold-coated ferric oxide and gold nanoparticles, applied in microcapsule preparation, microsphere preparation, inorganic material magnetism, etc., can solve the problem of poor reproducibility of preparation products, harsh experimental conditions, and difficult to control morphology and other problems, to achieve the effect of low production cost, good reproducibility and easy operation

Inactive Publication Date: 2010-07-14
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its various preparation methods have various advantages and disadvantages due to the limitation of its own experimental conditions: the co-precipitation method is simple and convenient to operate, but its morphology is difficult to control, and the monodispersity is relatively poor (Chem.Mater.1996,8,2209- 2211) Nano-Fe3O4 particles prepared by pyrolysis have better monodispersity, but their precursors are more expensive
The hydrothermal synthesis method (Adv.Mater.2008, 20, 1721-1726) is relatively harsh on the experimental conditions, and the reproducibility of the prepared product is not good
However, the production yield of microemulsion method is low

Method used

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  • Method for synthesizing gold-coated ferroferric oxide nano particles
  • Method for synthesizing gold-coated ferroferric oxide nano particles
  • Method for synthesizing gold-coated ferroferric oxide nano particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1) Weigh 0.104g FeSO 4 ·7H 2 O dissolved in 1ml KNO 3 (2M / L), then add 1ml NaOH (1M / L), mix well, then add 8ml PEI (5g / L molecular weight 10,000), package it into a microwave reactor, and heat at 90°C for 120min. Wash by magnetic separation and disperse in 10ml deionized water (Solution A).

[0025] 2) Measure 1ml 1% HAucl 4 The solution was dropped into 90 ml of ultrapure water and stirred magnetically for 1 min, then 2 ml of trisodium citrate (38.8 mM) was added dropwise and stirred for 1 min. Finally add 1ml of freshly prepared 0.075% NaBH 4 Trisodium citrate (38.8mM), continue magnetic stirring for 5min. Then store in a refrigerator at 4°C (solution B).

[0026] 3) Sonicate solution A for 2 minutes, measure 2ml and mix it with solution B. Finally, disperse in 20ml deionized water, add 110ml 0.01M NaOH, add 0.75ml NH for the first time 2 OH·Hcl (hydroxylamine hydrochloride), 0.5ml 1% HAucl 4 , followed by adding 0.5ml NH at intervals 2 OH·HCl, 0.5ml 1%HAucl...

Embodiment 2

[0029] 1) Weigh 0.104g FeSO 4 ·7H 2 O dissolved in 1ml KNO 3 (2M / L), then add 1ml NaOH (1M / L), mix well, then add 8ml PEI (5g / L molecular weight 25,000), package it into a microwave reactor, and heat at 90°C for 120min. Wash by magnetic separation and disperse in 10ml deionized water (Solution A).

[0030] 2) Measure 1ml 1% HAucl 4 The solution was dropped into 90 ml of ultrapure water and stirred magnetically for 1 min, then 2 ml of trisodium citrate (38.8 mM) was added dropwise and stirred for 1 min. Finally add 1ml of freshly prepared 0.075% NaBH 4 Trisodium citrate (38.8mM), continue magnetic stirring for 5min. Then store in a refrigerator at 4°C (solution B).

[0031] 3) Sonicate solution A for 2 minutes, measure 2 ml and mix it with solution B for 90 minutes. Finally, disperse in 20ml deionized water, add 110ml 0.01M NaOH, add 0.75ml NH for the first time 2 OH·Hcl (hydroxylamine hydrochloride), 0.5ml 1% HAucl 4 , followed by adding 0.5ml NH at intervals 2 OH·HC...

Embodiment 3

[0033] 1) Weigh 0.104g FeSO 4 Dissolve 7H2O in 1ml KNO3 (2M / L), then add 1ml NaOH (1M / L), mix well, then add 8ml PEI (4g / L molecular weight is 10,000), package and put it into a microwave reactor, heat at 90°C for 120min . Wash by magnetic separation and disperse in 10ml deionized water (Solution A).

[0034] 2) Measure 1ml 1% HAucl 4 The solution was dropped into 90 ml of ultrapure water and stirred magnetically for 1 min, then 2 ml of trisodium citrate (38.8 mM) was added dropwise and stirred for 1 min. Finally add 1ml of freshly prepared 0.075% NaBH 4 Trisodium citrate (38.8mM), continue magnetic stirring for 5min. Then store in a refrigerator at 4°C (solution B).

[0035] 3) Sonicate solution A for 2 minutes, measure 2ml and mix it with solution B and stir for 120 minutes. Finally, disperse in 20ml deionized water, add 110ml 0.01M NaOH, add 0.75ml NH for the first time 2 OH·Hcl (hydroxylamine hydrochloride), 0.5ml 1% HAucl 4 , followed by adding 0.5ml NH at interva...

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Abstract

The invention relates to a method for synthesizing gold-coated ferroferric oxide nano particles, which relates to a nano particle with core-shell structure. The method comprises the steps of: mixing FeSO4.7H2O, KNO3 solution, NaOH solution and PEI solution, putting the mixture in a microwave reactor for reaction, then dispersing the mixture in the water to obtain the ferroferric oxide nano particle; adding HAucl4 solution into ultrapure water; then adding sodium citrate, mixing and adding sodium citrate containing NaBH4, and continuing to mix so as to obtain gold nano particle solution; and adding gold nano particle solution into Fe3O4-PEI solution, mixing the solution, then adding PEI solution, placing the mixture in an oven, dispersing the mixture in de-ionized water after magnetic separation and washing, adding NaOH, adding NH2OH.HCl and HAuCl4, and then adding NH2OH.HCl and HAuCl4 for four times at intervals of at least 10 minutes each time.

Description

technical field [0001] The invention relates to a nanoparticle with a core-shell structure, in particular to a method for synthesizing a gold-coated ferric oxide nanoparticle. Background technique [0002] Nanocomposites with core-shell structure have attracted extensive attention in recent years because of their special structures and properties. Composite nanoparticles with iron oxide as the core and gold as the coating have become the focus of attention. Iron oxides with superparamagnetism have been applied to the fields of biological detection and imaging, targeted release of drugs and gene therapy, etc. However, due to the large specific surface area of ​​iron oxide nanoparticles in a neutral pH environment, It is easy to cause aggregation under the human pH environment, thus limiting its application and requiring further surface modification. Gold has good chemical stability and good biocompatibility, and it is easy to form Au-S with sulfhydryl groups, making it easy...

Claims

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Application Information

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IPC IPC(8): B01J13/02H01F1/11
Inventor 张其清徐文龙周樨
Owner XIAMEN UNIV