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Ginkgo flavone aglycone solid dispersion and preparation method thereof

A technology of ginkgo flavone aglycone and solid dispersion, which is applied in the field of medicine and can solve the problems of in vivo absorption and the like.

Inactive Publication Date: 2010-07-21
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This patented technology still has not solved the problem of its absorption in the body

Method used

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  • Ginkgo flavone aglycone solid dispersion and preparation method thereof
  • Ginkgo flavone aglycone solid dispersion and preparation method thereof
  • Ginkgo flavone aglycone solid dispersion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Take 10g of polyethylene glycol 4000 and 0.5g of talcum powder, mix well, heat to melt the polyethylene glycol 4000, add 1g of ginkgo flavonoid aglycone, mix well, quickly pour the molten material on the steel plate and spread it, and put it in the refrigerator at -20℃ , frozen for 8 hours, then transferred to a vacuum drying oven to continue drying at room temperature for 24 to 48 hours, taken out and ground, and passed through an 80-mesh sieve to obtain a solid dispersion of ginkgo flavonoid aglycone. The cumulative dissolution rate of the solid dispersion within 45 minutes was 80.67%±1.62%.

Embodiment 2

[0024] Take 5g of polyethylene glycol 4000 and 5g of micro-powdered silica gel and mix well, heat to melt the polyethylene glycol 4000, add 1g of ginkgo flavonoid aglycone, mix well, quickly pour the melted material on the steel plate and spread it, put it in the -20℃ refrigerator, Freeze for 8 hours, then transfer to a vacuum drying oven to continue drying at room temperature for 24 to 48 hours, take out and grind, and pass through an 80-mesh sieve to obtain a solid dispersion of ginkgo flavonoid aglycone. The cumulative dissolution percentage of the solid dispersion within 45 minutes was 86.75%±2.34%.

Embodiment 3

[0026] Take 10g of poloxamer 188 and 5g of micro-powder silica gel, mix well, heat to melt polyethylene glycol 4000, add 1g of ginkgo flavonoid aglycone, mix well, quickly pour the molten material on a steel plate, and put it in a -20°C refrigerator. Freeze for 8 hours, then transfer to a vacuum drying oven to continue drying at room temperature for 24 to 48 hours, take out and grind, and pass through an 80-mesh sieve to obtain a solid dispersion of ginkgo flavonoid aglycone. The cumulative dissolution rate of the solid dispersion within 45 minutes was 89.64%±1.37%.

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Abstract

The invention relates to a ginkgo flavone aglycone solid dispersion and a preparation method thereof. The solid dispersion adopts ginkgo flavone aglycone as active ingredient, is added with polymer carrier material, antioxidant and antisticking agent according to the proportion of 1: (0.2-15): (0-5): (0.2-15), and is prepared by a melting method, a coprecipitation method, a solvent dispersion method, a solvent melting method or a grinding method. The polymer carrier material is one or more in povidones, polyethylene glycols, poloxamers, polyoxyethylene stearic acid, hydroxymethyl propyl celluloses and low-viscosity Eudragit; the antioxidant is one or more in vitamin E, vitamin C or edetate disodium; the antisticking agent is one or more in talcum powder, micropowder silica gel, magnesium stearate or other auxiliary materials which can be taken as the antisticking agents. The ginkgo flavone aglycone solid dispersion can improve the solubility of medicine, leads the solubility to be 5-500 times higher than that of raw medicine, accelerates the dissolution rate of the medicine, and remarkably improves the dissolution rate in a dissolution medium within 45min in an accumulated way.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a solid dispersion of ginkgo flavonoid aglycone and a preparation method thereof. Background technique [0002] Ginkgo biloba is the leaf of Ginkgo biloba L. Ginkgo biloba originates in my country, and exists in places such as Tianmu Mountain and Dabie Mountain in Zhejiang Province as wild species. The flavonoids in Ginkgo biloba usually exist in the form of inactive glycosides. Only after being decomposed by the glucosidase of the intestinal flora, the flavonoid aglycone of Ginkgo biloba has biological activity. The glycoside ginkgo flavonoids that have not been decomposed by the intestinal flora are not easily absorbed, and are directly excreted from the bile into the intestinal tract. Many studies have shown that ginkgo flavonoid aglycone has a variety of biological activities. In addition to its antibacterial, anti-inflammatory, anti-mutation, antihypertensive,...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/352A61K9/20A61K9/48A61K9/16A61K9/06A61P31/04A61P29/00A61P9/12A61P25/20A61P7/10A61P39/06A61P35/00
Inventor 康冀川钱一鑫徐琳琳何珺文庭池
Owner GUIZHOU UNIV
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