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Medicine compound of mecobalamin and light magnesium oxide and preparation method thereof

A technology of light magnesium oxide and composition, applied in the field of medicine, can solve the problems of inconvenient storage and application of methylcobalamin, easy decomposition, unstable light exposure, etc., achieves good treatment of peripheral neuropathy, good stability, and improved use efficacy Effect

Active Publication Date: 2012-01-11
BEIJING SIHUAN PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Methylcobalamin is photosensitive, unstable and easy to decompose when exposed to light, which brings certain inconvenience and difficulty to the preservation and application of methylcobalamin

Method used

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  • Medicine compound of mecobalamin and light magnesium oxide and preparation method thereof
  • Medicine compound of mecobalamin and light magnesium oxide and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1 Preparation of the pharmaceutical composition capsule of the present invention

[0041] 1. Prescription

[0042] Prescription 1

[0043] Methylcobalamin 0.5g

[0044] Light magnesium oxide 0.5g

[0045] Starch 20g

[0046] Microcrystalline cellulose 50g

[0047] Sodium Carboxymethyl Starch 5.0g

[0048] 2% hypromellose ethanol solution appropriate amount

[0049] Talc 0.7g

[0050] A total of 1000 capsules are prepared

[0051] Prescription 2

[0052] Methylcobalamin 0.5g

[0053] Light magnesium oxide 1g

[0054] Starch 20g

[0055] Microcrystalline cellulose 50g

[0056] Sodium Carboxymethyl Starch 5.0g

[0057] 2% hypromellose ethanol solution appropriate amount

[0058] Talc 0.7g

[0059] A total of 1000 capsules are prepared

[0060] Prescription 3

[0061] Methylcobalamin 0.5g ...

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Abstract

The invention belongs to the technical field of medicines, in particular to a medicine compound of mecobalamin and light magnesium oxide and a preparation method thereof. The weight ratio of the mecobalamin to the light magnesium oxide is 1:0.5-5; the medicine compound and a pharmaceutically acceptable auxiliary material are prepared into an oral preparation. The invention also provides the preparation method of the medicine compound capsule and the application of the medicine compound of the invention in preparing medicines for curing peripheral neuropathy.

Description

1. Technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a pharmaceutical composition of mecobalamin and light magnesium oxide and a preparation method thereof. 2. Background technology [0002] Methylcobalamin is an endogenous coenzyme B 12 , Participates in the one-carbon unit cycle, and plays an important role in the transmethylation reaction of synthesizing methionine from homocysteine. [0003] Methylcobalamin is easier to enter neuronal organelles than cyanocobalamin, participates in the synthesis of thymidine in brain cells and spinal cord neurons, promotes the utilization of folic acid and nucleic acid metabolism, and promotes nucleic acid and protein synthesis stronger than cyanocobalamin; Axon transport function and axon regeneration, normalize the transport of sciatic nerve axon skeleton protein in streptozotocin-induced diabetic rats; for drug-induced neurodegeneration, such as doxorubicin, acrylamide, vincristine ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/714A61K33/08A61K9/48A61P25/02
Inventor 车冯升郭维城贾中新霍彩霞孟宪慧
Owner BEIJING SIHUAN PHARMA
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