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Cellulose magnetic microsphere and preparation method thereof

A technology of magnetic microspheres and cellulose, applied in the preparation of cellulose magnetic microspheres, in the field of cellulose magnetic microspheres, can solve the problems of poor magnetic response, low application efficiency of magnetic microspheres, and large distribution range, and achieve magnetic response Strong, simple method, low cost effect

Inactive Publication Date: 2010-07-21
王树森
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The particle size distribution range of the magnetic polymer microspheres prepared in the early stage is too large, the magnetic response is poor, and the application efficiency of the magnetic microspheres is low, so it is necessary to improve the preparation method of the magnetic microspheres

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] (1), preparation of cellulose solution

[0020] Methylmorpholine oxide (ie NMMO) was evaporated under reduced pressure at 60°C to remove moisture, and the moisture in the solution was detected with a non-aqueous titrator until the moisture content was lower than 11%.

[0021] Mix microcrystalline cellulose (solid powder) and NMMO solution at a weight ratio of 8:100, and leave overnight to form a uniform solution.

[0022] (2) Preparation of superparamagnetic iron core

[0023] 5 parts by weight of FeCl 2 4H 2 O is dissolved in 100 parts by weight of deionized water, added in 70 parts by weight of polyethylene glycol 8000 to dissolve it, slowly adding 100 parts by weight of H with a mass concentration of 15% 2 o 2 , after mixing, start to heat slowly, and adjust the pH to 10.5 with 6N NaOH solution, and react in a water bath at 50°C for 2 hours to obtain a brown-black magnetic fluid.

[0024] (3), preparation of cellulose magnetic microspheres

[0025] The cellulos...

Embodiment 2

[0028] (1), preparation of cellulose solution

[0029] Methyl morpholine oxide (ie NMMO) was evaporated under reduced pressure at 80°C to remove moisture, and the moisture in the solution was detected with a non-aqueous titrator until the moisture content was lower than 11%.

[0030] The degreased cotton and NMMO solution were mixed at a weight ratio of 5:100, and left overnight to form a uniform solution.

[0031] (2) Preparation of superparamagnetic iron core

[0032] 6 parts by weight of FeCl 2 4H 2 O is dissolved in 100 parts by weight of deionized water, added in 80 parts by weight of polyethylene glycol 4000 to dissolve it, slowly adding 110 parts by weight of H with a mass concentration of 15% 2 o 2 After mixing, start to heat slowly, adjust the pH to 10.5 with 6N NaOH solution, and react in a water bath at 60°C for 2 hours to obtain a brown-black magnetic fluid.

[0033] (3), preparation of cellulose magnetic microspheres

[0034] The cellulose solution prepared ...

Embodiment 3

[0037] (1), preparation of cellulose solution

[0038] Methylmorpholine oxide (NMMO) was evaporated under reduced pressure at 50°C to remove water, and the water in the solution was detected with a non-aqueous titrator until the water content was lower than 11%.

[0039] Mix microcrystalline cellulose (solid powder) and NMMO solution at a weight ratio of 10:100, and leave overnight to form a uniform solution.

[0040] (2) Preparation of superparamagnetic iron core

[0041] 8 parts by weight of FeCl 2 4H 2 O is dissolved in 100 parts by weight of deionized water, added in 75 parts by weight of polyethylene glycol 6000 to dissolve it, and slowly adding 105 parts by weight of H with a mass concentration of 15%. 2 o 2 , after mixing, start to heat slowly, and adjust the pH to 10.5 with 6N NaOH solution, and react in a water bath at 55°C for 2 hours to obtain a brown-black magnetic fluid.

[0042] (3), preparation of cellulose magnetic microspheres

[0043] The cellulose solu...

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Abstract

The invention discloses a cellulose magnetic microsphere and a preparation method thereof, wherein the preparation method comprises the following steps: a. evenly mixing cellulose and methylmorpholine solution in the weight ratio of 5-10:100; b. dissolving 5-8 parts of FeCl2.4H2O into 100 parts of deionized water; adding 70-80 parts of polyethylene glycol and then adding 100-110 parts of 15 percent H2O2 for evenly mixing, adding 6N of NaOH solution and adjusting the pH value to 10.5 and reacting the solution at 50-60 DEG C to obtain browmnish black magnetofluid; and c. mixing the cellulose solution and the browmnish black magnetofluid in the volume ratio of 3-8:1 and adding the mixture into 10-15 parts by volume of liquid paraffin containing 1-2.5 percent of SPAN80, stirring the mixture at the rotating speed of 8,000-12,000rpm for 6-15min, then transferring the solution into 100 parts by volume of same liquid paraffin, stirring the mixture at the rotating speed of 400-2,500rpm and at the temperature of 45-60DEG C for 50-120min, and cooling to obtain a separated magnetic microsphere. The microsphere has the advantages of uniform grain diameter distribution, good dispersity and strong magnetic response.

Description

technical field [0001] The invention relates to a magnetic microsphere, in particular to a cellulose magnetic microsphere, and also relates to a preparation method of the cellulose magnetic microsphere. Background technique [0002] Magnetic microspheres, because of their surface can be endowed with various special functional groups that react with biologically active substances, and because of their superparamagnetism, they can be quickly separated under the action of an external magnetic field, making the separation technology cheap, fast and efficient. Therefore, it shows strong vitality in many fields such as biomedicine, cytology, molecular biology and material science. [0003] The particle size distribution range of the magnetic polymer microspheres prepared in the early stage is too large, and the magnetic response is poor, resulting in low application efficiency of the magnetic microspheres. Therefore, it is necessary to improve the preparation method of the magneti...

Claims

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Application Information

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IPC IPC(8): B01J13/02H01F1/11
Inventor 王树森
Owner 王树森
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