Atorvastatin calcium oral disintegrating tablet and preparation method thereof

Abstract

The invention provides an atorvastatin calcium oral disintegrating tablet prescription and a preparation method thereof. The atorvastatin calcium oral disintegrating tablet prescription comprises atorvastatin calcium, a bitter covering agent, a filling agent, a disintegrant, a lubricant, and the like. The invention is technically characterized by providing a particle preparing technology which not only can effectively cover the bitter of the atorvastatin calcium, but also can lead the atorvastatin calcium oral disintegrating tablet to be disintegrated in the mouth. The atorvastatin calcium oral disintegrating tablet with pressure of above 4kg and disintegrating time within 30 seconds can be prepared by adding normal supplementary materials of filling agents, disintegrants, lubricants, and the like of oral disintegrating tablets and is easy to realize industrial scale production.

Description

technical field [0001] The invention relates to a technology for preparing orally disintegrating atorvastatin calcium tablets, specifically a method of preparing atorvastatin calcium into orally disintegrating tablets by wrapping atorvastatin calcium into odorless microcapsule particles with polymer materials, which is used in medical technology field. Background technique [0002] Due to the improvement of people's living standards, more and more people are troubled by hyperlipidemia (commonly known as hyperlipidemia), and the incidence of hyperlipidemia tends to be younger and younger, extending from the original elderly to 35 years old Middle-aged people around. Hyperlipidemia is very dangerous. If it is not treated for a long time, it will lead to cardiovascular and cerebrovascular diseases such as atherosclerosis, stroke, hypertension and coronary heart disease. It is known as the "invisible killer". Hyperlipidemia, also known as dyslipidemia, mainly refers to the inc...

AI Technical Summary

Problems solved by technology

Among these methods, physical and chemical methods are widely used in experimental research, but their production feasibility is relatively poor; physical methods are more feasible for large-scale production, but the pellets or granules produced by the fluidized bed method have a large particle size and are difficult to disintegrate in the oral cavity. It may cause a gritty feeling during application; the particle size produced by the spray drying method is small, and the oral disintegration tablet does not cause a gritty feel, but the drug loading and encapsulation efficiency are low

Our experimental research shows that using spray drying technology, the bitter taste is already felt when the drug content reaches more than 10%, and the high encapsulation rate can only reach 34%.

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