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Preparation method for o-hydroxy-phenyl alkyl ether

A technology of o-hydroxyphenyl alkyl ether and hydroxyphenyl alkyl ether, which is applied in the field of compound preparation, can solve the problems of large environmental pollution, low yield of o-hydroxyanisole or o-hydroxyphenethyl ether, and high production cost , to achieve the effects of reducing environmental pollution, reducing the generation of by-products, and reducing production costs

Inactive Publication Date: 2010-08-25
CHONGQING THRIVE CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0011] Due to the generation of the above two by-products, the yield of o-hydroxyanisole or o-hydroxyphenetole is lower, the production cost is higher, and the environmental pollution is larger

Method used

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  • Preparation method for o-hydroxy-phenyl alkyl ether
  • Preparation method for o-hydroxy-phenyl alkyl ether
  • Preparation method for o-hydroxy-phenyl alkyl ether

Examples

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Embodiment Construction

[0020] In order to make the object, technical solution and advantages of the present invention clearer, preferred embodiments of the present invention are described in detail below.

[0021] 1. Raw materials and equipment

[0022] Catechol (purity ≥ 98.5%) was purchased from Lianyungang Sanjili Chemical Industry Co., Ltd.; methyl chloride (purity ≥ 99.5%) and ethyl chloride (purity ≥ 99.5%) were purchased from Sichuan Zigong Honghe Chemical Co., Ltd.; GAH- Type 5 high-pressure reactor was purchased from Shandong Weihai Huixin Chemical Machinery Co., Ltd.

[0023] Two, the preparation of o-hydroxyanisole

[0024] Add 47.1g of catechol, 150g of toluene and 8002.4g of polyethylene glycol into the autoclave, tighten the autoclave, vacuumize, fill the autoclave with inert gas, and then pass it under stirring conditions (400r / min). Slowly add 50mL of aqueous solution dissolved with 16.1g of sodium hydroxide, 80mL of sodium carbonate and / or potassium carbonate aqueous solution into...

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Abstract

The invention discloses a method for preparing o-hydroxy-phenyl alkyl ether shown as a formula I which is obtain by adopting pyrocatechol and halohydrocarbon shown as the formula I as starting materials to carry out Williamson reaction in the presence of alkali, wherein the adopted alkali is the mixture of sodium hydroxide, sodium carbonate and potassium carbonate or the mixture of sodium hydroxide and potassium carbonate, and the reaction is carried out under the protection of inert gas. By adopting the method of the invention, by-product generation can be reduced, product yield can be greatly improved, production cost is lowered and environmental pollution is decreased simultaneously.

Description

technical field [0001] The invention relates to a preparation method of a compound, in particular to a preparation method of o-hydroxyphenyl alkyl ether. Background technique [0002] O-hydroxyanisole and o-hydroxyphenethyl ether are important fine chemical raw materials, widely used in the synthesis of pharmaceutical chemicals, spices and dyes, especially for the synthesis of vanillin. [0003] The preparation method of o-hydroxyanisole and o-hydroxyphenetole reported in the literature is mainly divided into two classes according to the difference of starting materials: (1) with corresponding antho-aminoanisole or o-aminophenetole as starting raw material, through heavy It can be prepared by nitriding and hydrolysis reaction; (2) It can be prepared by reacting catechol with the corresponding dimethyl sulfate or diethyl sulfate, or with the corresponding halogenated hydrocarbon through alkylation reaction. [0004] The Williamson reaction of catechol with the corresponding ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C41/16C07C43/23
Inventor 马学兵洪炜肖琳珊赵华文韦勇谭修万
Owner CHONGQING THRIVE CHEM